Dietary d-allulose alters cholesterol metabolism in Golden Syrian hamsters partly by reducing serum PCSK9 levels
[Display omitted] •Dietary d-allulose modulated the cholesterol profiles of hamster lipoproteins.•d-Allulose reduced serum PCSK9, a negative regulator of LDL-cholesterol levels.•The LDL/HDL ratio, an atherogenic index, decreased after d-allulose ingestion.•d-Allulose could improve cholesterol metabo...
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| Published in | Journal of functional foods Vol. 60; p. 103429 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier Ltd
01.09.2019
Elsevier |
| Subjects | |
| Online Access | Get full text |
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| Abstract | [Display omitted]
•Dietary d-allulose modulated the cholesterol profiles of hamster lipoproteins.•d-Allulose reduced serum PCSK9, a negative regulator of LDL-cholesterol levels.•The LDL/HDL ratio, an atherogenic index, decreased after d-allulose ingestion.•d-Allulose could improve cholesterol metabolism and reduce atherosclerosis risk.
d-Allulose, a C-3 epimer of d-fructose, is a rare sugar reported to be a non-caloric sweetener having several health beneficial effects including anti-hyperglycemia and anti-obesity. However, the impact of dietary d-allulose on cholesterol metabolism remains unclear. Therefore, we studied the effects of d-allulose on the cholesterol metabolism of Golden Syrian hamsters, an animal model with a lipid metabolism similar to that of humans. Hamsters received either normal diet (ND) or high-fat diet (HFD) with or without 3% d-allulose for 4 or 8 weeks. While there were no significant differences in total serum cholesterol levels between the groups, d-allulose significantly increased HDL-cholesterol levels in ND-fed hamsters and decreased LDL-cholesterol levels in HFD-fed hamsters, causing an overall decrease in the LDL/HDL ratio. Furthermore, dietary d-allulose decreased serum proprotein convertase subtilisin/kexin type 9 (PCSK9) levels in both diets. In conclusion, d-allulose may favorably modulate cholesterol metabolism by reducing PCSK9 in hamsters. |
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| AbstractList | [Display omitted]
•Dietary d-allulose modulated the cholesterol profiles of hamster lipoproteins.•d-Allulose reduced serum PCSK9, a negative regulator of LDL-cholesterol levels.•The LDL/HDL ratio, an atherogenic index, decreased after d-allulose ingestion.•d-Allulose could improve cholesterol metabolism and reduce atherosclerosis risk.
d-Allulose, a C-3 epimer of d-fructose, is a rare sugar reported to be a non-caloric sweetener having several health beneficial effects including anti-hyperglycemia and anti-obesity. However, the impact of dietary d-allulose on cholesterol metabolism remains unclear. Therefore, we studied the effects of d-allulose on the cholesterol metabolism of Golden Syrian hamsters, an animal model with a lipid metabolism similar to that of humans. Hamsters received either normal diet (ND) or high-fat diet (HFD) with or without 3% d-allulose for 4 or 8 weeks. While there were no significant differences in total serum cholesterol levels between the groups, d-allulose significantly increased HDL-cholesterol levels in ND-fed hamsters and decreased LDL-cholesterol levels in HFD-fed hamsters, causing an overall decrease in the LDL/HDL ratio. Furthermore, dietary d-allulose decreased serum proprotein convertase subtilisin/kexin type 9 (PCSK9) levels in both diets. In conclusion, d-allulose may favorably modulate cholesterol metabolism by reducing PCSK9 in hamsters. d-Allulose, a C-3 epimer of d-fructose, is a rare sugar reported to be a non-caloric sweetener having several health beneficial effects including anti-hyperglycemia and anti-obesity. However, the impact of dietary d-allulose on cholesterol metabolism remains unclear. Therefore, we studied the effects of d-allulose on the cholesterol metabolism of Golden Syrian hamsters, an animal model with a lipid metabolism similar to that of humans. Hamsters received either normal diet (ND) or high-fat diet (HFD) with or without 3% d-allulose for 4 or 8 weeks. While there were no significant differences in total serum cholesterol levels between the groups, d-allulose significantly increased HDL-cholesterol levels in ND-fed hamsters and decreased LDL-cholesterol levels in HFD-fed hamsters, causing an overall decrease in the LDL/HDL ratio. Furthermore, dietary d-allulose decreased serum proprotein convertase subtilisin/kexin type 9 (PCSK9) levels in both diets. In conclusion, d-allulose may favorably modulate cholesterol metabolism by reducing PCSK9 in hamsters. |
| ArticleNumber | 103429 |
| Author | Iida, Tetsuo Kanasaki, Akane Jiang, Zhe Sato, Masao Mizokami, Takuya Shirouchi, Bungo Nagata, Yasuo |
| Author_xml | – sequence: 1 givenname: Akane surname: Kanasaki fullname: Kanasaki, Akane email: akane-kanasaki@matsutani.co.jp organization: Research and Development, Matsutani Chemical Industry Co., Ltd., 5-3 Kita-Itami, Itami City, Hyogo 664-8508, Japan – sequence: 2 givenname: Zhe surname: Jiang fullname: Jiang, Zhe organization: Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan – sequence: 3 givenname: Takuya surname: Mizokami fullname: Mizokami, Takuya organization: Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan – sequence: 4 givenname: Bungo orcidid: 0000-0003-4237-5081 surname: Shirouchi fullname: Shirouchi, Bungo organization: Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan – sequence: 5 givenname: Tetsuo surname: Iida fullname: Iida, Tetsuo organization: Research and Development, Matsutani Chemical Industry Co., Ltd., 5-3 Kita-Itami, Itami City, Hyogo 664-8508, Japan – sequence: 6 givenname: Yasuo surname: Nagata fullname: Nagata, Yasuo organization: Center for Industry, University and Government Cooperation, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan – sequence: 7 givenname: Masao surname: Sato fullname: Sato, Masao organization: Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan |
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| Keywords | d-Allulose CETP AST SREBP HFD LXR MTP PCSK9 ALT Hamsters LDL/HDL ratio NPC1L1 ND IDOL CD36 GC-FID γ-GTP |
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•Dietary d-allulose modulated the cholesterol profiles of hamster lipoproteins.•d-Allulose reduced serum PCSK9, a negative regulator of... d-Allulose, a C-3 epimer of d-fructose, is a rare sugar reported to be a non-caloric sweetener having several health beneficial effects including... |
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| Title | Dietary d-allulose alters cholesterol metabolism in Golden Syrian hamsters partly by reducing serum PCSK9 levels |
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