Quantitative description of the phase-separation behavior of the multivalent SLP65-CIN85 complex

• Published in: PNAS nexus Vol. 3; no. 3; p. pgae079
• Main Authors: Maier, Joachim, Sieme, Daniel, Wong, Leo E, Dar, Furqan, Wienands, Jürgen, Becker, Stefan, Griesinger, Christian
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.03.2024
• Subjects: B cells; Immune response; Proline; Proteins; Thermodynamics; BLNK; phase separation; SLP65; CIN85; biomolecular condensates

Biomolecular condensates play a major role in cell compartmentalization, besides membrane-enclosed organelles. The multivalent SLP65 and CIN85 proteins are proximal B-cell antigen receptor (BCR) signal effectors and critical for proper immune responses. In association with intracellular vesicles, th...