Enhanced corneal permeation and antimycotic activity of itraconazole against Candida albicans via a novel nanosystem vesicle

• Published in: Drug delivery Vol. 23; no. 7; pp. 2115 - 2123
• Main Authors: ElMeshad, Aliaa N., Mohsen, Amira M.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.09.2016
• Subjects: Animals; Antifungal Agents - administration & dosage; Antifungal Agents - chemistry; Candida albicans; Candida albicans - drug effects; Cornea - metabolism; Drug Carriers - chemistry; Drug Compounding - methods; Drug Delivery Systems - methods; elasticity; itraconazole; Itraconazole - administration & dosage; Itraconazole - chemistry; Liposomes - administration & dosage; Liposomes - chemistry; Male; niosomes; Particle Size; Permeability; Polysorbates - chemistry; Rabbits; spanlastics; Candida albicans; niosomes; itraconazole; elasticity; spanlastics

The objective of this study was to investigate the potential of spanlastics as an ophthalmic delivery system to improve the corneal permeability and antimycotic activity of itraconazole (ITZ). Spanlastics containing edge activators, including Tween 20 or 80, were produced by modified ethanol injecti...