Uninterrupted in vivo cerebral microdialysis measures of the acute neurochemical response to a single or repeated concussion in a rat model combining force and rotation

• Published in: Brain research Vol. 1838; p. 148998
• Main Authors: Massé, Ian, Moquin, Luc, Bouchard, Caroline, Gratton, Alain, De Beaumont, Louis
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2024
• Subjects: Amino acids; Animals; Brain Concussion - metabolism; Cerebral microdialysis; Concussion; Disease Models, Animal; gamma-Aminobutyric Acid - metabolism; Glutamate; Glutamic Acid - metabolism; Glycine - metabolism; Head acceleration; Hippocampus - metabolism; Male; Microdialysis - methods; Neurochemical response; Rats; Rats, Sprague-Dawley; Taurine - metabolism; Amino acids; ECF; CNS; PFA; Head acceleration; ACSF; Glutamate; Neurochemical response; CA1; Cerebral microdialysis; Concussion; Ca2; MD; NMDA; GABA; TBI; mTBI

[Display omitted] •Unveils acute neurochemical changes in concussions using microdialysis in rats.•Demonstrates significant glutamate and taurine increase after a single concussion.•Reveals less neurochemical changes, aggravated symptoms after repeated concussions.•Introduces a novel rat model combi...