Effects of pressed degreased walnut meal extracts on lipid metabolism in postnatally monosodium glutamate-induced mice and 3T3-L1 preadipocytes
•Added some new knowledge of constituents and bioactivity of walnut meal extracts.•Ascertained principal constituents in the extracts of pressed degreased walnut meal.•Revealed hypolipidemic effects of the extracts on monosodium glutamate-induced mice.•Shown hypoglycemic potential of the extracts on...
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Published in | Journal of functional foods Vol. 31; pp. 89 - 96 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier Ltd
01.04.2017
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | •Added some new knowledge of constituents and bioactivity of walnut meal extracts.•Ascertained principal constituents in the extracts of pressed degreased walnut meal.•Revealed hypolipidemic effects of the extracts on monosodium glutamate-induced mice.•Shown hypoglycemic potential of the extracts on monosodium glutamate-induced mice.•The extracts could inhibit the differentiation of 3T3-L1 preadipocytes.
Twelve polyphenols were identified in the extracts (WMP) from cold pressed degreased walnut meal by UPLC-ESI-MS, among which glansreginin A, gallic acid, ellagic acid and ellagic acid 4-O-xyloside took up the majority proportion. The potential of WMP to improve glucose and lipid metabolism was investigated by the postnatally monosodium glutamate (MSG)-induced mice. The levels of serum total cholesterol, triacylglycerols, low-density lipoprotein cholesterol, glucose, and adiponectin, ascending in the MSG group, had a significant decrease after the WMP treatment with the corresponding increase of high-density lipoprotein cholesterol level. The administration of WMP suppressed the weight gain and fat accumulation. Furthermore, activities of alanine transaminase, aspartate transaminase and malondialdehyde level decreased obviously compared to the MSG group, however, activities of glutathione peroxidase and superoxide dismutase went higher after the WMP treatment in liver. Our findings have posed WMP the potential to treat obesity and related disorders by improving glucose and lipid metabolism. |
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ISSN: | 1756-4646 2214-9414 |
DOI: | 10.1016/j.jff.2017.01.026 |