Cyanidin-3-O-β-glucoside and protocatechuic acid activate AMPK/mTOR/S6K pathway and improve glucose homeostasis in mice

• Published in: Journal of functional foods Vol. 21; pp. 338 - 348
• Main Authors: Talagavadi, Veena, Rapisarda, Paolo, Galvano, Fabio, Pelicci, Piergiuseppe, Giorgio, Marco
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.03.2016; Elsevier
• Subjects: AMPK; Anthocyanin; Blood oranges; Glucose homeostasis; Laboratory mice; mTOR; Anthocyanin; Glucose homeostasis; GTT; HFD; T2D; ITT; Laboratory mice; WB; EDTA; EGTA; PCA; SD; C3G; FBS; mTOR; AMPK; Blood oranges

•C3G and PCA activate AMPK and inhibit mTOR and S6K.•C3G and PCA upregulate glucose transporters.•C3G and PCA improve glucose tolerance and insulin sensitivity.•PCA sources are promising protectors for type-2 diabetes.•Blood orange juice improves insulin sensitivity. AMP-activated protein kinase (AM...