Doubly derivatized poly(lactide)–albumin nanoparticles as blood vessel-targeted transport device for magnetic resonance imaging (MRI)

• Published in: Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology Vol. 23; no. 2
• Main Authors: Pashkunova-Martic, Irena, Kremser, Christian, Talasz, Heribert, Mistlberger, Klaudia, Bechter-Hugl, Beate, Pfaller, Kristian, Baurecht, Dieter, Debbage, Paul, Jaschke, Werner, Helbich, Thomas H., Keppler, Bernhard
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.02.2021; Springer Nature B.V
• Subjects: Antibodies; Binding; Biodegradability; Biodegradation; Blood vessels; Bovine serum albumin; Characterization and Evaluation of Materials; Chemistry and Materials Science; Contrast agents; Contrast media; Core-shell structure; Coupling; Coupling (molecular); Crosslinking; Electron microscopy; Endothelial cells; Endothelium; Gadolinium; Inorganic Chemistry; Lasers; Lectins; Lipophilic; Macromolecules; Magnetic resonance imaging; Materials Science; Medical imaging; Microscopy; Nanoparticles; Nanotechnology; Optical Devices; Optics; Photonics; Physical Chemistry; Polylactic acid; Reagents; Research Paper; Serum albumin; Size exclusion chromatography; Tomatoes; Transmission electron microscopy; Veins; Nanoparticles; Poly(lactide)-albumin; Tomato lectin; Targeting; MRI; Endothelial cells

Molecular imaging using magnetic resonance imaging (MRI) is expected to play a crucial future role in oncological diagnosis and in monitoring of therapeutic progress. Targeted nanoparticle contrast media (CM) with high relaxivities are required in order to obtain adequate signal-to-noise ratios as w...