Effects of maternal age on the expression of mesenchymal stem cell markers in the components of human umbilical cord

• Published in: Folia histochemica et cytobiologica Vol. 53; no. 3; pp. 259 - 271
• Main Authors: Alrefaei, Ghadeer I., Ayuob, Nasra N., Ali, Soad S., Al-Karim, Saleh
• Format: Journal Article
• Language: English
• Published: Poland Wydawnictwo Via Medica 01.01.2015
• Subjects: Adult; Age; Amniotic membrane; Antigens; Antigens, CD - genetics; Antigens, CD - metabolism; Biomarkers; Biomarkers - blood; CD105 antigen; CD29 antigen; Endoglin; Female; Fetuses; Gene expression; Gene Expression Regulation - physiology; Humans; Immunohistochemistry; Integrin beta1 - genetics; Integrin beta1 - metabolism; Maternal Age; Medical wastes; Mesenchymal stem cells; Mesenchymal Stromal Cells - cytology; Middle Aged; Real-Time Polymerase Chain Reaction; Receptors, Cell Surface - genetics; Receptors, Cell Surface - metabolism; Regenerative medicine; Stem cells; Umbilical cord; Umbilical Cord - cytology; Umbilical vein; mothers’ age; IHC; RT-PCR; CD29; CD105; MSC; umbilical cord

Although the human umbilical cord (UC) has been previously considered a medical waste, its use as a main source of fetal stem cells for regenerative medicine applications has increased over the past few years. The aim of the study was to assess the impact of the maternal age on the expression of mes...