Long non‑coding RNA CASC2 ameliorates sepsis‑induced acute kidney injury by regulating the miR‑155 and NF‑κB pathway

• Published in: International journal of molecular medicine Vol. 45; no. 5; pp. 1554 - 1562
• Main Authors: Wang, Min, Wei, Jilou, Shang, Futai, Zang, Kui, Ji, Ting
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications UK Ltd 01.05.2020
• Subjects: Acute Kidney Injury - genetics; Adult; Aged; Animals; Apoptosis; Apoptosis - genetics; Cancer; Cell growth; Cell Line; Cell Survival - genetics; Down-Regulation - genetics; Female; Gene Expression Regulation, Neoplastic - genetics; HEK293 Cells; Humans; Inflammation - genetics; Kidneys; Laboratory animals; Male; Males; Mice; Mice, Inbred BALB C; MicroRNAs; MicroRNAs - genetics; Middle Aged; NF-kappa B - genetics; Oxidative Stress - genetics; Sepsis; Sepsis - genetics; Tumor necrosis factor-TNF; Tumor Suppressor Proteins - genetics; Up-Regulation - genetics; Young Adult

Sepsis is a systemic inflammatory response syndrome that can cause multiple‑organ damage, including acute kidney injury (AKI). Studies have shown that the long non‑coding RNA cancer susceptibility candidate 2 (CASC2) is involved in the occurrence and development of multiple human diseases, although...