Potential Therapeutic Improvements in Prostate Cancer Treatment Using Pencil Beam Scanning Proton Therapy with LETd Optimization and Disease-Specific RBE Models

• Published in: Cancers Vol. 16; no. 4; p. 780
• Main Authors: Vieceli, Michael, Park, Jiyeon, Hsi, Wen Chien, Saki, Mo, Mendenhall, Nancy P., Johnson, Perry, Artz, Mark
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.02.2024
• Subjects: Cancer therapies; Clinical outcomes; disease-specific/prostate-cancer-specific LET-dependent RBE modeling; Dosimetry; LET-optimized pencil beam scanning proton therapy; Optimization; Patients; Prostate cancer; prostate cancer treatment; Protons; Radiation therapy; Risk groups; Scanning; Statistical analysis; Toxicity; X-rays

Purpose: To demonstrate the feasibility of improving prostate cancer patient outcomes with PBS proton LETd optimization. Methods: SFO, IPT-SIB, and LET-optimized plans were created for 12 patients, and generalized-tissue and disease-specific LET-dependent RBE models were applied. The mean LETd in se...