Aerosolized Calfactant for Newborns With Respiratory Distress: A Randomized Trial

• Published in: Pediatrics (Evanston) Vol. 146; no. 5; p. e20193967
• Main Authors: Cummings, James J, Gerday, Erick, Minton, Stephen, Katheria, Anup, Albert, George, Flores-Torres, Jaime, Famuyide, Mobolaji, Lampland, Andrea, Guthrie, Scott, Kuehn, Devon, Weitkamp, Jörn-Hendrik, Fort, Prem, Abu Jawdeh, Elie G, Ryan, Rita M, Martin, Gregory C, Swanson, Jonathan R, Mulrooney, Neil, Eyal, Fabien, Gerstmann, Dale, Kumar, Praveen, Wilding, Greg E, Egan, Edmund A
• Format: Journal Article
• Language: English
• Published: United States American Academy of Pediatrics 01.11.2020
• Subjects: Administration, Oral; Aerosols; Biological Products - administration & dosage; Birth weight; Body weight; Cohort Studies; Female; Gestation; Gestational Age; Humans; Infant, Newborn; Infants; Intensive Care Units, Neonatal - statistics & numerical data; Intubation; Intubation, Intratracheal - statistics & numerical data; Male; Mechanical ventilation; Nebulizers and Vaporizers; Neonates; Newborn babies; Pediatrics; Phospholipids; Prospective Studies; Pulmonary Surfactants - administration & dosage; Respiratory distress syndrome; Respiratory Distress Syndrome, Newborn - drug therapy; Surfactants

Exogenous surfactants to treat respiratory distress syndrome (RDS) are approved for tracheal instillation only; this requires intubation, often followed by positive pressure ventilation to promote distribution. Aerosol delivery offers a safer alternative, but clinical studies have had mixed results....