Effect of a selective chloride channel activator, lubiprostone, on gastrointestinal transit, gastric sensory, and motor functions in healthy volunteers

• Published in: American journal of physiology: Gastrointestinal and liver physiology Vol. 290; no. 5; pp. G942 - G947
• Main Authors: Camilleri, Michael, Bharucha, Adil E, Ueno, Ryuji, Burton, Duane, Thomforde, George M, Baxter, Kari, McKinzie, Sanna, Zinsmeister, Alan R
• Format: Journal Article
• Language: English
• Published: United States 01.05.2006
• Subjects: Adolescent; Adult; Alprostadil - adverse effects; Alprostadil - analogs & derivatives; Alprostadil - pharmacology; Chloride Channels - physiology; Double-Blind Method; Fatty Acids - adverse effects; Fatty Acids - pharmacology; Female; Gastric Emptying - drug effects; Gastrointestinal Transit - drug effects; Humans; Lubiprostone; Male; Middle Aged; Placebos; Stomach - physiology

Chloride channels modulate gastrointestinal neuromuscular functions in vitro. Lubiprostone, a selective type 2 chloride channel (ClC-2) activator, induces intestinal secretion and has been shown to relieve constipation in clinical trials; however, the effects of lubiprostone on gastric function and...