RRP Regulates Autophagy through the AMPK Pathway to Alleviate the Effect of Cell Senescence on Atherosclerosis
Autophagy is closely associated with atherosclerosis and other cardiovascular diseases (CVD). Compound Danshen prescription is widely used as a clinical antiatherosclerotic drug. In our previous studies, we have shown that the combined active component, ginsenoside Rg1-notoginsenoside R1-protocatech...
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Published in | Oxidative medicine and cellular longevity Vol. 2023; pp. 9645789 - 22 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
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Hindawi
2023
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Abstract | Autophagy is closely associated with atherosclerosis and other cardiovascular diseases (CVD). Compound Danshen prescription is widely used as a clinical antiatherosclerotic drug. In our previous studies, we have shown that the combined active component, ginsenoside Rg1-notoginsenoside R1-protocatechualdehyde (RRP), can effectively alleviate endothelial dysfunction and reduce atherosclerotic plaques. However, the association between cellular senescence, caused by reduced autophagy, and atherosclerosis remains unclear. In this study, we investigated whether RRP can enhance autophagy and alleviate cell senescence through the AMPK pathway. Our results showed that RRP reduced the secretion of inflammatory factors in the serum of atherosclerotic mice, enhanced autophagy, and alleviated aortic aging in mice, thus reducing atherosclerotic plaques. In human aortic endothelial cells (HAECs), RRP effectively enhanced autophagy and inhibited senescence by activating the AMPK pathway. When AMPKα was silenced, the effect of RRP was inhibited, thus reversing its antiaging effect. Overall, our results show that RRP regulates autophagy through the AMPK pathway, thereby inhibiting cell senescence and alleviating the progression of atherosclerosis, suggesting that RRP may be a potential candidate drug for the treatment of atherosclerosis. |
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AbstractList | Autophagy is closely associated with atherosclerosis and other cardiovascular diseases (CVD). Compound Danshen prescription is widely used as a clinical antiatherosclerotic drug. In our previous studies, we have shown that the combined active component, ginsenoside Rg1-notoginsenoside R1-protocatechualdehyde (RRP), can effectively alleviate endothelial dysfunction and reduce atherosclerotic plaques. However, the association between cellular senescence, caused by reduced autophagy, and atherosclerosis remains unclear. In this study, we investigated whether RRP can enhance autophagy and alleviate cell senescence through the AMPK pathway. Our results showed that RRP reduced the secretion of inflammatory factors in the serum of atherosclerotic mice, enhanced autophagy, and alleviated aortic aging in mice, thus reducing atherosclerotic plaques. In human aortic endothelial cells (HAECs), RRP effectively enhanced autophagy and inhibited senescence by activating the AMPK pathway. When AMPKα was silenced, the effect of RRP was inhibited, thus reversing its antiaging effect. Overall, our results show that RRP regulates autophagy through the AMPK pathway, thereby inhibiting cell senescence and alleviating the progression of atherosclerosis, suggesting that RRP may be a potential candidate drug for the treatment of atherosclerosis. Autophagy is closely associated with atherosclerosis and other cardiovascular diseases (CVD). Compound Danshen prescription is widely used as a clinical antiatherosclerotic drug. In our previous studies, we have shown that the combined active component, ginsenoside Rg1-notoginsenoside R1-protocatechualdehyde (RRP), can effectively alleviate endothelial dysfunction and reduce atherosclerotic plaques. However, the association between cellular senescence, caused by reduced autophagy, and atherosclerosis remains unclear. In this study, we investigated whether RRP can enhance autophagy and alleviate cell senescence through the AMPK pathway. Our results showed that RRP reduced the secretion of inflammatory factors in the serum of atherosclerotic mice, enhanced autophagy, and alleviated aortic aging in mice, thus reducing atherosclerotic plaques. In human aortic endothelial cells (HAECs), RRP effectively enhanced autophagy and inhibited senescence by activating the AMPK pathway. When AMPK α was silenced, the effect of RRP was inhibited, thus reversing its antiaging effect. Overall, our results show that RRP regulates autophagy through the AMPK pathway, thereby inhibiting cell senescence and alleviating the progression of atherosclerosis, suggesting that RRP may be a potential candidate drug for the treatment of atherosclerosis. Autophagy is closely associated with atherosclerosis and other cardiovascular diseases (CVD). Compound Danshen prescription is widely used as a clinical antiatherosclerotic drug. In our previous studies, we have shown that the combined active component, ginsenoside Rg1-notoginsenoside R1-protocatechualdehyde (RRP), can effectively alleviate endothelial dysfunction and reduce atherosclerotic plaques. However, the association between cellular senescence, caused by reduced autophagy, and atherosclerosis remains unclear. In this study, we investigated whether RRP can enhance autophagy and alleviate cell senescence through the AMPK pathway. Our results showed that RRP reduced the secretion of inflammatory factors in the serum of atherosclerotic mice, enhanced autophagy, and alleviated aortic aging in mice, thus reducing atherosclerotic plaques. In human aortic endothelial cells (HAECs), RRP effectively enhanced autophagy and inhibited senescence by activating the AMPK pathway. When AMPK was silenced, the effect of RRP was inhibited, thus reversing its antiaging effect. Overall, our results show that RRP regulates autophagy through the AMPK pathway, thereby inhibiting cell senescence and alleviating the progression of atherosclerosis, suggesting that RRP may be a potential candidate drug for the treatment of atherosclerosis. |
Author | Yang, Qiong Liu, Dekun Lin, Lin Niu, Xingchen Song, Tinging Zhang, Dan Song, Yueyue Zhang, Lei Liang, Dan Yin, Jiufeng Yang, Wenqing |
AuthorAffiliation | 2 Innovation Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China 5 Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan, China 6 Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, China 1 Faculty of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China 4 Shandong Province Cardiovascular Disease Chinese Medicine Precision Diagnosis Engineering Laboratory, Shandong University of Traditional Chinese Medicine, Jinan, China 3 Faculty of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China |
AuthorAffiliation_xml | – name: 4 Shandong Province Cardiovascular Disease Chinese Medicine Precision Diagnosis Engineering Laboratory, Shandong University of Traditional Chinese Medicine, Jinan, China – name: 6 Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, China – name: 2 Innovation Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China – name: 3 Faculty of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China – name: 1 Faculty of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China – name: 5 Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan, China |
Author_xml | – sequence: 1 givenname: Dekun orcidid: 0000-0002-1104-2965 surname: Liu fullname: Liu, Dekun organization: Faculty of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJinanChinasdutcm.edu.cn – sequence: 2 givenname: Yueyue surname: Song fullname: Song, Yueyue organization: Innovation Institute of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJinanChinasdutcm.edu.cn – sequence: 3 givenname: Tinging surname: Song fullname: Song, Tinging organization: Faculty of PharmacyShandong University of Traditional Chinese MedicineJinanChinasdutcm.edu.cn – sequence: 4 givenname: Lin surname: Lin fullname: Lin, Lin organization: Innovation Institute of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJinanChinasdutcm.edu.cn – sequence: 5 givenname: Lei surname: Zhang fullname: Zhang, Lei organization: Innovation Institute of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJinanChinasdutcm.edu.cn – sequence: 6 givenname: Qiong surname: Yang fullname: Yang, Qiong organization: Innovation Institute of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJinanChinasdutcm.edu.cn – sequence: 7 givenname: Xingchen surname: Niu fullname: Niu, Xingchen organization: Innovation Institute of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJinanChinasdutcm.edu.cn – sequence: 8 givenname: Dan surname: Liang fullname: Liang, Dan organization: Innovation Institute of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJinanChinasdutcm.edu.cn – sequence: 9 givenname: Jiufeng surname: Yin fullname: Yin, Jiufeng organization: Innovation Institute of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJinanChinasdutcm.edu.cn – sequence: 10 givenname: Wenqing orcidid: 0000-0003-4622-7393 surname: Yang fullname: Yang, Wenqing organization: Innovation Institute of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJinanChinasdutcm.edu.cn – sequence: 11 givenname: Dan orcidid: 0000-0001-7475-0750 surname: Zhang fullname: Zhang, Dan organization: Experimental CenterShandong University of Traditional Chinese MedicineJinanChinasdutcm.edu.cn |
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CitedBy_id | crossref_primary_10_1016_j_atherosclerosis_2024_117575 crossref_primary_10_3389_fphar_2024_1380977 crossref_primary_10_1166_jbn_2023_3668 |
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Copyright | Copyright © 2023 Dekun Liu et al. Copyright © 2023 Dekun Liu et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0 Copyright © 2023 Dekun Liu et al. 2023 |
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Snippet | Autophagy is closely associated with atherosclerosis and other cardiovascular diseases (CVD). Compound Danshen prescription is widely used as a clinical... |
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StartPage | 9645789 |
SubjectTerms | AMP-Activated Protein Kinases - metabolism Animals Apoptosis Atherosclerosis Atherosclerosis - drug therapy Atherosclerosis - metabolism Autophagy Cell culture Cell cycle Cell growth Cellular Senescence - physiology Chinese medicine Coronary vessels Endothelial Cells - metabolism Enzymes Experiments Humans Medical research Mice Oxidative stress Plaque, Atherosclerotic - metabolism Senescence Signal Transduction |
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Title | RRP Regulates Autophagy through the AMPK Pathway to Alleviate the Effect of Cell Senescence on Atherosclerosis |
URI | https://dx.doi.org/10.1155/2023/9645789 https://www.ncbi.nlm.nih.gov/pubmed/36756298 https://www.proquest.com/docview/2775459433/abstract/ https://search.proquest.com/docview/2774894993 https://pubmed.ncbi.nlm.nih.gov/PMC9902129 |
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