Regulation of α-synuclein expression in down syndrome
The triplication of genes located on chromosome 21 is known to cause a wide spectrum of pathology seen in Down syndrome (DS), including leukemia, seizures, stroke, and mental retardation. Studies on RNA and protein expression of genes in DS brain have demonstrated the role of triplicated genes in se...
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Published in | Journal of neuroscience research Vol. 90; no. 8; pp. 1589 - 1596 |
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Abstract | The triplication of genes located on chromosome 21 is known to cause a wide spectrum of pathology seen in Down syndrome (DS), including leukemia, seizures, stroke, and mental retardation. Studies on RNA and protein expression of genes in DS brain have demonstrated the role of triplicated genes in several DS phenotypes. Significant changes in the expression of nontriplicated genes have also been observed. However, little information is available regarding the role of nonchromosome 21 genes in DS pathology. We have found that α‐synuclein (SNCA), a presynaptic protein whose gene is located on chromosome 6 in the Ts65Dn mouse model for DS, is significantly reduced in the cortex and other brain regions. We hypothesize that this alteration may play a critical role in the reduced synaptic function observed in DS. We have found an increase in the level of neurosin, a key negative regulator of SNCA in Ts65Dn cortex. We have also found increased levels of protein phosphatase 2A, a negative regulator of the activation of tyrosine hydroxylase and a key enzyme in the biosynthetic pathway for dopamine in Ts65Dn cortex. These findings reveal potential target sites for intervention in the treatment of DS pathology. © 2012 Wiley Periodicals, Inc. |
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AbstractList | The triplication of genes located on chromosome 21 is known to cause a wide spectrum of pathology seen in Down syndrome (DS), including leukemia, seizures, stroke, and mental retardation. Studies on RNA and protein expression of genes in DS brain have demonstrated the role of triplicated genes in several DS phenotypes. Significant changes in the expression of nontriplicated genes have also been observed. However, little information is available regarding the role of nonchromosome 21 genes in DS pathology. We have found that α‐synuclein (SNCA), a presynaptic protein whose gene is located on chromosome 6 in the Ts65Dn mouse model for DS, is significantly reduced in the cortex and other brain regions. We hypothesize that this alteration may play a critical role in the reduced synaptic function observed in DS. We have found an increase in the level of neurosin, a key negative regulator of SNCA in Ts65Dn cortex. We have also found increased levels of protein phosphatase 2A, a negative regulator of the activation of tyrosine hydroxylase and a key enzyme in the biosynthetic pathway for dopamine in Ts65Dn cortex. These findings reveal potential target sites for intervention in the treatment of DS pathology. © 2012 Wiley Periodicals, Inc. The triplication of genes located on chromosome 21 is known to cause a wide spectrum of pathology seen in Down syndrome (DS), including leukemia, seizures, stroke, and mental retardation. Studies on RNA and protein expression of genes in DS brain have demonstrated the role of triplicated genes in several DS phenotypes. Significant changes in the expression of nontriplicated genes have also been observed. However, little information is available regarding the role of nonchromosome 21 genes in DS pathology. We have found that α-synuclein (SNCA), a presynaptic protein whose gene is located on chromosome 6 in the Ts65Dn mouse model for DS, is significantly reduced in the cortex and other brain regions. We hypothesize that this alteration may play a critical role in the reduced synaptic function observed in DS. We have found an increase in the level of neurosin, a key negative regulator of SNCA in Ts65Dn cortex. We have also found increased levels of protein phosphatase 2A, a negative regulator of the activation of tyrosine hydroxylase and a key enzyme in the biosynthetic pathway for dopamine in Ts65Dn cortex. These findings reveal potential target sites for intervention in the treatment of DS pathology. Abstract The triplication of genes located on chromosome 21 is known to cause a wide spectrum of pathology seen in Down syndrome (DS), including leukemia, seizures, stroke, and mental retardation. Studies on RNA and protein expression of genes in DS brain have demonstrated the role of triplicated genes in several DS phenotypes. Significant changes in the expression of nontriplicated genes have also been observed. However, little information is available regarding the role of nonchromosome 21 genes in DS pathology. We have found that α‐synuclein (SNCA), a presynaptic protein whose gene is located on chromosome 6 in the Ts65Dn mouse model for DS, is significantly reduced in the cortex and other brain regions. We hypothesize that this alteration may play a critical role in the reduced synaptic function observed in DS. We have found an increase in the level of neurosin, a key negative regulator of SNCA in Ts65Dn cortex. We have also found increased levels of protein phosphatase 2A, a negative regulator of the activation of tyrosine hydroxylase and a key enzyme in the biosynthetic pathway for dopamine in Ts65Dn cortex. These findings reveal potential target sites for intervention in the treatment of DS pathology. © 2012 Wiley Periodicals, Inc. |
Author | Patel, Satyam Brown, Ted W. Ramakrishna, Narayan El Idrissi, Abdeslem Meeker, Harry C. |
Author_xml | – sequence: 1 givenname: Narayan surname: Ramakrishna fullname: Ramakrishna, Narayan email: narayan.ramakrishna@gmail.com organization: Department Molecular Biology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York – sequence: 2 givenname: Harry C. surname: Meeker fullname: Meeker, Harry C. organization: Department of Virology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York – sequence: 3 givenname: Satyam surname: Patel fullname: Patel, Satyam organization: Department Molecular Biology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York – sequence: 4 givenname: Ted W. surname: Brown fullname: Brown, Ted W. organization: Department of Human Genetics, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York – sequence: 5 givenname: Abdeslem surname: El Idrissi fullname: El Idrissi, Abdeslem organization: Department of Biology, College of Staten Island, City University of New York, Staten Island, New York |
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Cites_doi | 10.1016/j.cell.2005.09.028 10.1523/JNEUROSCI.1766-04.2004 10.1038/ng0298-106 10.1101/gr.1951304 10.1038/ncb2131 10.1016/S0166-2236(97)01213-7 10.1016/j.neuroscience.2008.07.025 10.1111/j.1471-4159.2004.02423.x 10.1016/S0896-6273(00)80886-7 10.1016/j.ab.2005.02.002 10.1002/ana.410200413 10.1073/pnas.0803756105 10.1523/JNEUROSCI.2922-05.2005 10.1126/science.276.5321.2045 10.1523/JNEUROSCI.22-20-08797.2002 10.1523/JNEUROSCI.3821-06.2006 10.1016/0169-328X(91)90043-W 10.1126/science.1090278 10.1016/j.neures.2010.04.008 10.1002/ana.10795 10.1002/ana.10846 10.1097/00001756-199909090-00019 10.1126/science.1129462 10.1021/bi00032a006 10.1046/j.1471-4159.2003.01614.x 10.1371/journal.pone.0015522 10.1002/ana.67 10.1074/jbc.M110.100867 10.1111/1467-8624.00522 10.1046/j.1471-4159.1998.71010338.x 10.1523/JNEUROSCI.20-09-03214.2000 10.1016/j.neuroscience.2009.03.049 10.1242/jcs.02481 10.1016/0014-5793(94)00395-5 |
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References | Chandra S,Gallardo G,Fernandez-Chacon R,Schluter OM,Sudhof TC. 2005. Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell 123: 383-396. Ramakrishna N,Meeker C,Li S,Jenkins EC,Currie JR,Flory M,Lee B,Liu MS,Miller DL. 2005. Polymerase chain reaction method to identify Down syndrome model segmentally trisomic mice. Anal Biochem 340: 213-219. Fortin DL,Nemani VM,Voglmaier SM,Anthony MD,Ryan TA,Edwards RH. 2005. Neural activity controls the synaptic accumulation of alpha-synuclein. J Neurosci 25: 10913-10921. Lou H,Montoya SE,Alerte TN,Wang J,Wu J,Peng X,Hong CS,Friedrich EE,Mader SA,Pedersen CJ,Marcus BS,McCormack AL,Di Monte DA,Daubner SC,Perez RG. 2010. Serine 129 phosphorylation reduces the ability of alpha-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo. J Biol Chem 285: 17648-17661. Ramakrishna N,Meeker HC,Li S,Brown WT,Rao R,El Idrissi A. 2009. Upregulation of beta-catenin expression in down syndrome model Ts65Dn mouse brain. Neuroscience 161: 451-458. Cabin DE,Shimazu K,Murphy D,Cole NB,Gottschalk W,McIlwain KL,Orrison B,Chen A,Ellis CE,Paylor R,Lu B,Nussbaum RL. 2002. Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein. J Neurosci 22: 8797-8807. Murphy DD,Rueter SM,Trojanowski JQ,Lee VM. 2000. Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons. J Neurosci 20: 3214-3220. Voronov SV,Frere SG,Giovedi S,Pollina EA,Borel C,Zhang H,Schmidt C,Akeson EC,Wenk MR,Cimasoni L,Arancio O,Davisson MT,Antonarakis SE,Gardiner K,De Camilli P,Di Paolo G. 2008. Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome. Proc Natl Acad Sci U S A 105: 9415-9420. Abeliovich A,Schmitz Y,Farinas I,Choi-Lundberg D,Ho WH,Castillo PE,Shinsky N,Verdugo JM,Armanini M,Ryan A,Hynes M,Phillips H,Sulzer D,Rosenthal A. 2000. Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 25: 239-252. Peng X,Tehranian R,Dietrich P,Stefanis L,Perez RG. 2005. Alpha-synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cells. J Cell Sci 118: 3523-3530. Pollonini G,Gao V,Rabe A,Palminiello S,Albertini G,Alberini CM. 2008. Abnormal expression of synaptic proteins and neurotrophin-3 in the Down syndrome mouse model Ts65Dn. Neuroscience 156: 99-106. Farrer M,Kachergus J,Forno L,Lincoln S,Wang DS,Hulihan M,Maraganore D,Gwinn-Hardy K,Wszolek Z,Dickson D,Langston JW. 2004. Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications. Ann Neurol 55: 174-179. Larsen KE,Schmitz Y,Troyer MD,Mosharov E,Dietrich P,Quazi AZ,Savalle M,Nemani V,Chaudhry FA,Edwards RH,Stefanis L,Sulzer D. 2006. Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis. J Neurosci 26: 11915-11922. Clayton DF,George JM. 1998. The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease. Trends Neurosci 21: 249-254. Soitropoulou GP. 2005. Mechanisms of pharmacological modulation of human kallikrein 6 gene expression in breast tumor cell lines. Cell Mol Biol 25 [Gene Methylation in Cancer]. Kleschevnikov AM,Belichenko PV,Villar AJ,Epstein CJ,Malenka RC,Mobley WC. 2004. Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome. J Neurosci 24: 8153-8160. Matsumoto L,Takama H,Tamaoka A,Kurisaki H,Date H,Tsuji S,Iwata A. 2010. CpG Demethylation Enhances Alpha-Synucein Expression and Affects the Pathogenesis of Parkinson's Disease. PLOS One 5: 1-9. Bayer TA,Jakala P,Hartmann T,Egensperger R,Buslei R,Falkai P,Beyreuther K. 1999. Neural expression profile of alpha-synuclein in developing human cortex. Neuroreport 10: 2799-2803. Perez RG,Hastings TG. 2004. Could a loss of alpha-synuclein function put dopaminergic neurons at risk? J Neurochem 89: 1318-1324. Howell MG. 2012. Altered synaptic marker abundance in the hippocampal striatum oriens of Ts65Dn mice is associated wit exuberant expression of versican. ASN NEURO immediate publication AN20110037 (January). Singleton AB,Farrer M,Johnson J,Singleton A,Hague S,Kachergus J,Hulihan M,Peuralinna T,Dutra A,Nussbaum R,Lincoln S,Crawley A,Hanson M,Maraganore D,Adler C,Cookson MR,Muenter M,Baptista M,Miller D,Blancato J,Hardy J,Gwinn-Hardy K. 2003. Alpha-synuclein locus triplication causes Parkinson's disease. Science 302: 841. Becker LE,Armstrong DL,Chan F. 1986. Dendritic atrophy in children with Down's syndrome. Ann Neurol 20: 520-526. Maroteaux L,Scheller RH. 1991. The rat brain synucleins; family of proteins transiently associated with neuronal membrane. Brain Res Mol Brain Res 11: 335-343. Spillantini MG,Schmidt ML,Lee VM,Trojanowski JQ,Jakes R,Goedert M. 1997. Alpha-synuclein in Lewy bodies. Nature 388: 839-840. Kruger R,Kuhn W,Muller T,Woitalla D,Graeber M,Kosel S,Przuntek H,Epplen JT,Schols L,Riess O. 1998. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat Genet 18: 106-108. Pennington BF,Moon J,Edgin J,Stedron J,Nadel L. 2003. The neuropsychology of Down syndrome: evidence for hippocampal dysfunction. Child Dev 74: 75-93. Engidawork E,Lubec G. 2003. Molecular changes in fetal Down syndrome brain. J Neurochem 84: 895-904. Jakes R,Spillantini MG,Goedert M. 1994. Identification of two distinct synucleins from human brain. FEBS Lett 345: 27-32. Zarranz JJ,Alegre J,Gomez-Esteban JC,Lezcano E,Ros R,Ampuero I,Vidal L,Hoenicka J,Rodriguez O,Atares B,Llorens V,Gomez Tortosa E,del Ser T,Munoz DG,de Yebenes JG. 2004. The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann Neurol 55: 164-173. Kahlem P,Sultan M,Herwig R,Steinfath M,Balzereit D,Eppens B,Saran NG,Pletcher MT,South ST,Stetten G,Lehrach H,Reeves RH,Yaspo ML. 2004. Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome. Genome Res 14: 1258-1267. Baba M,Nakajo S,Tu PH,Tomita T,Nakaya K,Lee VM,Trojanowski JQ,Iwatsubo T. 1998. Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am J Pathol 152: 879-884. Epstein CJ,Berger CN,Carlson EJ,Chan PH,Huang TT. 1990. Models for Down syndrome: chromosome 21-specific genes in mice. Prog Clin Biol Res 360: 215-232. Sharma M,Burre J,Sudhof TC. 2011. CSPalpha promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity. Nat Cell Biol 13: 30-39. Cooper AA,Gitler AD,Cashikar A,Haynes CM,Hill KJ,Bhullar B,Liu K,Xu K,Strathearn KE,Liu F,Cao S,Caldwell KA,Caldwell GA,Marsischky G,Kolodner RD,Labaer J,Rochet JC,Bonini NM,Lindquist S. 2006. Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science 313: 324-328. Tatebe H,Watanabe Y,Kasai T,Mizuno T,Nakagawa M,Tanaka M,Tokuda T. 2010. Extracellular neurosin degrades alpha-synuclein in cultured cells. Neurosci Res 67: 341-346. Iwai A,Yoshimoto M,Masliah E,Saitoh T. 1995. Non-A beta component of Alzheimer's disease amyloid (NAC) is amyloidogenic. Biochemistry 34: 10139-10145. Polymeropoulos MH,Lavedan C,Leroy E,Ide SE,Dehejia A,Dutra A,Pike B,Root H,Rubenstein J,Boyer R,Stenroos ES,Chandrasekharappa S,Athanassiadou A,Papapetropoulos T,Johnson WG,Lazzarini AM,Duvoisin RC,Di Iorio G,Golbe LI,Nussbaum RL. 1997. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276: 2045-2047. Hsu LJ,Mallory M,Xia Y,Veinbergs I,Hashimoto M,Yoshimoto M,Thal LJ,Saitoh T,Masliah E. 1998. Expression pattern of synucleins (non-Abeta component of Alzheimer's disease amyloid precursor protein/alpha-synuclein) during murine brain development. J Neurochem 71: 338-344. 2000; 25 2012 1991; 11 1995; 34 2004; 89 1997; 276 2004; 24 2000; 20 2005; 118 2010; 285 2011; 13 2008; 105 2006; 313 1998; 21 2003; 74 1998; 152 1990; 360 2005; 25 1997; 388 2010; 67 2004; 55 1998; 18 1994; 345 2005; 340 1986; 20 2005; 123 2004; 14 2002; 22 2006; 26 1999; 10 2009; 161 1998; 71 2008; 156 2003; 302 2003; 84 2010; 5 Baba M (e_1_2_6_3_1) 1998; 152 e_1_2_6_32_1 e_1_2_6_10_1 e_1_2_6_31_1 e_1_2_6_30_1 Soitropoulou GP (e_1_2_6_35_1) 2005; 25 e_1_2_6_19_1 Epstein CJ (e_1_2_6_11_1) 1990; 360 Howell MG (e_1_2_6_14_1) 2012 e_1_2_6_13_1 e_1_2_6_36_1 e_1_2_6_34_1 e_1_2_6_12_1 e_1_2_6_33_1 e_1_2_6_17_1 e_1_2_6_18_1 e_1_2_6_39_1 e_1_2_6_15_1 e_1_2_6_38_1 e_1_2_6_16_1 e_1_2_6_37_1 e_1_2_6_21_1 e_1_2_6_20_1 e_1_2_6_9_1 e_1_2_6_8_1 e_1_2_6_5_1 e_1_2_6_4_1 e_1_2_6_7_1 e_1_2_6_6_1 e_1_2_6_25_1 e_1_2_6_24_1 e_1_2_6_23_1 e_1_2_6_2_1 e_1_2_6_22_1 e_1_2_6_29_1 e_1_2_6_28_1 e_1_2_6_27_1 e_1_2_6_26_1 |
References_xml | – volume: 24 start-page: 8153 year: 2004 end-page: 8160 article-title: Hippocampal long‐term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome publication-title: J Neurosci – volume: 13 start-page: 30 year: 2011 end-page: 39 article-title: CSPalpha promotes SNARE‐complex assembly by chaperoning SNAP‐25 during synaptic activity publication-title: Nat Cell Biol – volume: 10 start-page: 2799 year: 1999 end-page: 2803 article-title: Neural expression profile of alpha‐synuclein in developing human cortex publication-title: Neuroreport – volume: 276 start-page: 2045 year: 1997 end-page: 2047 article-title: Mutation in the alpha‐synuclein gene identified in families with Parkinson's disease publication-title: Science – volume: 152 start-page: 879 year: 1998 end-page: 884 article-title: Aggregation of alpha‐synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies publication-title: Am J Pathol – volume: 21 start-page: 249 year: 1998 end-page: 254 article-title: The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease publication-title: Trends Neurosci – volume: 89 start-page: 1318 year: 2004 end-page: 1324 article-title: Could a loss of alpha‐synuclein function put dopaminergic neurons at risk? publication-title: J Neurochem – volume: 20 start-page: 520 year: 1986 end-page: 526 article-title: Dendritic atrophy in children with Down's syndrome publication-title: Ann Neurol – volume: 156 start-page: 99 year: 2008 end-page: 106 article-title: Abnormal expression of synaptic proteins and neurotrophin‐3 in the Down syndrome mouse model Ts65Dn publication-title: Neuroscience – volume: 285 start-page: 17648 year: 2010 end-page: 17661 article-title: Serine 129 phosphorylation reduces the ability of alpha‐synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo publication-title: J Biol Chem – volume: 71 start-page: 338 year: 1998 end-page: 344 article-title: Expression pattern of synucleins (non‐Abeta component of Alzheimer's disease amyloid precursor protein/alpha‐synuclein) during murine brain development publication-title: J Neurochem – volume: 18 start-page: 106 year: 1998 end-page: 108 article-title: Ala30Pro mutation in the gene encoding alpha‐synuclein in Parkinson's disease publication-title: Nat Genet – volume: 5 start-page: 1 year: 2010 end-page: 9 article-title: CpG Demethylation Enhances Alpha‐Synucein Expression and Affects the Pathogenesis of Parkinson's Disease publication-title: PLOS One – volume: 345 start-page: 27 year: 1994 end-page: 32 article-title: Identification of two distinct synucleins from human brain publication-title: FEBS Lett – volume: 340 start-page: 213 year: 2005 end-page: 219 article-title: Polymerase chain reaction method to identify Down syndrome model segmentally trisomic mice publication-title: Anal Biochem – volume: 25 start-page: 10913 year: 2005 end-page: 10921 article-title: Neural activity controls the synaptic accumulation of alpha‐synuclein publication-title: J Neurosci – volume: 74 start-page: 75 year: 2003 end-page: 93 article-title: The neuropsychology of Down syndrome: evidence for hippocampal dysfunction publication-title: Child Dev – volume: 11 start-page: 335 year: 1991 end-page: 343 article-title: The rat brain synucleins; family of proteins transiently associated with neuronal membrane publication-title: Brain Res Mol Brain Res – volume: 55 start-page: 174 year: 2004 end-page: 179 article-title: Comparison of kindreds with parkinsonism and alpha‐synuclein genomic multiplications publication-title: Ann Neurol – volume: 25 year: 2005 article-title: Mechanisms of pharmacological modulation of human kallikrein 6 gene expression in breast tumor cell lines publication-title: Cell Mol Biol – volume: 313 start-page: 324 year: 2006 end-page: 328 article-title: Alpha‐synuclein blocks ER‐Golgi traffic and Rab1 rescues neuron loss in Parkinson's models publication-title: Science – year: 2012 article-title: Altered synaptic marker abundance in the hippocampal striatum oriens of Ts65Dn mice is associated wit exuberant expression of versican publication-title: ASN NEURO immediate publication AN20110037 (January) – volume: 22 start-page: 8797 year: 2002 end-page: 8807 article-title: Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha‐synuclein publication-title: J Neurosci – volume: 302 start-page: 841 year: 2003 article-title: Alpha‐synuclein locus triplication causes Parkinson's disease publication-title: Science – volume: 26 start-page: 11915 year: 2006 end-page: 11922 article-title: Alpha‐synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis publication-title: J Neurosci – volume: 14 start-page: 1258 year: 2004 end-page: 1267 article-title: Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome publication-title: Genome Res – volume: 84 start-page: 895 year: 2003 end-page: 904 article-title: Molecular changes in fetal Down syndrome brain publication-title: J Neurochem – volume: 388 start-page: 839 year: 1997 end-page: 840 article-title: Alpha‐synuclein in Lewy bodies publication-title: Nature – volume: 25 start-page: 239 year: 2000 end-page: 252 article-title: Mice lacking alpha‐synuclein display functional deficits in the nigrostriatal dopamine system publication-title: Neuron – volume: 67 start-page: 341 year: 2010 end-page: 346 article-title: Extracellular neurosin degrades alpha‐synuclein in cultured cells publication-title: Neurosci Res – volume: 105 start-page: 9415 year: 2008 end-page: 9420 article-title: Synaptojanin 1‐linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome publication-title: Proc Natl Acad Sci U S A – volume: 123 start-page: 383 year: 2005 end-page: 396 article-title: Alpha‐synuclein cooperates with CSPalpha in preventing neurodegeneration publication-title: Cell – volume: 34 start-page: 10139 year: 1995 end-page: 10145 article-title: Non‐A beta component of Alzheimer's disease amyloid (NAC) is amyloidogenic publication-title: Biochemistry – volume: 360 start-page: 215 year: 1990 end-page: 232 article-title: Models for Down syndrome: chromosome 21‐specific genes in mice publication-title: Prog Clin Biol Res – volume: 20 start-page: 3214 year: 2000 end-page: 3220 article-title: Synucleins are developmentally expressed, and alpha‐synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons publication-title: J Neurosci – volume: 55 start-page: 164 year: 2004 end-page: 173 article-title: The new mutation, E46K, of alpha‐synuclein causes Parkinson and Lewy body dementia publication-title: Ann Neurol – volume: 118 start-page: 3523 year: 2005 end-page: 3530 article-title: Alpha‐synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cells publication-title: J Cell Sci – volume: 161 start-page: 451 year: 2009 end-page: 458 article-title: Upregulation of beta‐catenin expression in down syndrome model Ts65Dn mouse brain publication-title: Neuroscience – ident: e_1_2_6_7_1 doi: 10.1016/j.cell.2005.09.028 – ident: e_1_2_6_19_1 doi: 10.1523/JNEUROSCI.1766-04.2004 – ident: e_1_2_6_20_1 doi: 10.1038/ng0298-106 – ident: e_1_2_6_18_1 doi: 10.1101/gr.1951304 – ident: e_1_2_6_33_1 doi: 10.1038/ncb2131 – ident: e_1_2_6_8_1 doi: 10.1016/S0166-2236(97)01213-7 – ident: e_1_2_6_29_1 doi: 10.1016/j.neuroscience.2008.07.025 – ident: e_1_2_6_28_1 doi: 10.1111/j.1471-4159.2004.02423.x – ident: e_1_2_6_2_1 doi: 10.1016/S0896-6273(00)80886-7 – ident: e_1_2_6_31_1 doi: 10.1016/j.ab.2005.02.002 – ident: e_1_2_6_5_1 doi: 10.1002/ana.410200413 – ident: e_1_2_6_38_1 doi: 10.1073/pnas.0803756105 – volume: 152 start-page: 879 year: 1998 ident: e_1_2_6_3_1 article-title: Aggregation of alpha‐synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies publication-title: Am J Pathol contributor: fullname: Baba M – ident: e_1_2_6_13_1 doi: 10.1523/JNEUROSCI.2922-05.2005 – ident: e_1_2_6_30_1 doi: 10.1126/science.276.5321.2045 – ident: e_1_2_6_6_1 doi: 10.1523/JNEUROSCI.22-20-08797.2002 – ident: e_1_2_6_21_1 doi: 10.1523/JNEUROSCI.3821-06.2006 – year: 2012 ident: e_1_2_6_14_1 article-title: Altered synaptic marker abundance in the hippocampal striatum oriens of Ts65Dn mice is associated wit exuberant expression of versican publication-title: ASN NEURO immediate publication AN20110037 (January) contributor: fullname: Howell MG – ident: e_1_2_6_23_1 doi: 10.1016/0169-328X(91)90043-W – ident: e_1_2_6_34_1 doi: 10.1126/science.1090278 – ident: e_1_2_6_37_1 doi: 10.1016/j.neures.2010.04.008 – ident: e_1_2_6_39_1 doi: 10.1002/ana.10795 – ident: e_1_2_6_12_1 doi: 10.1002/ana.10846 – ident: e_1_2_6_4_1 doi: 10.1097/00001756-199909090-00019 – ident: e_1_2_6_9_1 doi: 10.1126/science.1129462 – volume: 360 start-page: 215 year: 1990 ident: e_1_2_6_11_1 article-title: Models for Down syndrome: chromosome 21‐specific genes in mice publication-title: Prog Clin Biol Res contributor: fullname: Epstein CJ – ident: e_1_2_6_16_1 doi: 10.1021/bi00032a006 – ident: e_1_2_6_10_1 doi: 10.1046/j.1471-4159.2003.01614.x – ident: e_1_2_6_24_1 doi: 10.1371/journal.pone.0015522 – ident: e_1_2_6_36_1 doi: 10.1002/ana.67 – ident: e_1_2_6_22_1 doi: 10.1074/jbc.M110.100867 – volume: 25 year: 2005 ident: e_1_2_6_35_1 article-title: Mechanisms of pharmacological modulation of human kallikrein 6 gene expression in breast tumor cell lines publication-title: Cell Mol Biol contributor: fullname: Soitropoulou GP – ident: e_1_2_6_27_1 doi: 10.1111/1467-8624.00522 – ident: e_1_2_6_15_1 doi: 10.1046/j.1471-4159.1998.71010338.x – ident: e_1_2_6_25_1 doi: 10.1523/JNEUROSCI.20-09-03214.2000 – ident: e_1_2_6_32_1 doi: 10.1016/j.neuroscience.2009.03.049 – ident: e_1_2_6_26_1 doi: 10.1242/jcs.02481 – ident: e_1_2_6_17_1 doi: 10.1016/0014-5793(94)00395-5 |
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Snippet | The triplication of genes located on chromosome 21 is known to cause a wide spectrum of pathology seen in Down syndrome (DS), including leukemia, seizures,... Abstract The triplication of genes located on chromosome 21 is known to cause a wide spectrum of pathology seen in Down syndrome (DS), including leukemia,... |
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SubjectTerms | Adolescent Adult Aged alpha-Synuclein - biosynthesis Animals Blotting, Western Brain - metabolism Brain - physiopathology Disease Models, Animal Down Syndrome - metabolism Down Syndrome - physiopathology downregulation Humans Immunohistochemistry Kallikreins - metabolism Mice Middle Aged neurosin Protein Phosphatase 2 - metabolism Reverse Transcriptase Polymerase Chain Reaction Synaptic Transmission - physiology Ts65Dn mouse Young Adult α-synuclein |
Title | Regulation of α-synuclein expression in down syndrome |
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