Combined administration of cerebrolysin and donepezil induces plastic changes in prefrontal cortex in aged mice

• Published in: Synapse (New York, N.Y.) Vol. 66; no. 11; pp. 938 - 949
• Main Authors: Alcántara-González, Faviola, Mendoza-Perez, Claudia Rebeca, Zaragoza, Néstor, Juarez, Ismael, Arroyo-García, Luis Enrique, Gamboa, Citlalli, De La Cruz, Fidel, Zamudio, Sergio, Garcia-Dolores, Fernando, Flores, Gonzalo
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.11.2012
• Subjects: Aging; Alzheimer's disease; Amino Acids - pharmacology; Animals; cerebrolysin; dendritic morphology; Dendritic Spines - drug effects; Dendritic Spines - ultrastructure; donepezil; Drug Synergism; Golgi-Cox stain; Indans - pharmacology; Male; Mice; Motor Activity - drug effects; Neuronal Plasticity - drug effects; Nootropic Agents - pharmacology; Piperidines - pharmacology; Prefrontal Cortex - cytology; Prefrontal Cortex - drug effects; Prefrontal Cortex - physiology; Pyramidal Cells - cytology; Pyramidal Cells - drug effects; spine density

Cerebrolysin (Cbl) shows neurotrophic and neuroprotective properties while donepezil (Dnp) is a potent acetylcholinesterase (AChE) inhibitor, both drugs are prescribed for Alzheimer's disease (AD) treatment. Previous studies have shown that the Dnp and Cbl administered separately, modify dendri...