Exosomal microRNA‐16‐5p from human urine‐derived stem cells ameliorates diabetic nephropathy through protection of podocyte

• Published in: Journal of cellular and molecular medicine Vol. 25; no. 23; pp. 10798 - 10813
• Main Authors: Duan, Yu‐Rui, Chen, Bao‐Ping, Chen, Fang, Yang, Su‐Xia, Zhu, Chao‐Yang, Ma, Ya‐Li, Li, Yang, Shi, Jun
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.12.2021; John Wiley and Sons Inc
• Subjects: Angiogenesis; Animals; Apoptosis; Apoptosis - genetics; Bioinformatics; Cell Line; Diabetes; Diabetes mellitus; Diabetes Mellitus, Experimental - genetics; Diabetes Mellitus, Experimental - pathology; Diabetic Nephropathies - genetics; Diabetic Nephropathies - pathology; Diabetic nephropathy; Exosomes; Exosomes - genetics; Glucose - genetics; HEK293 Cells; human urine‐derived stem cells; Humans; Hyperglycemia; Male; MicroRNAs; MicroRNAs - genetics; microRNA‐16‐5p; miRNA; Nephropathy; Original; Plasmids; podocyte; Podocytes - pathology; Rats; Rats, Sprague-Dawley; Reagents; Stem cell transplantation; Stem cells; Stem Cells - pathology; Urine; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A; human urine-derived stem cells; vascular endothelial growth factor A; exosomes; microRNA-16-5p; diabetic nephropathy; podocyte

Diabetic nephropathy (DN) remains one of the severe complications associated with diabetes mellitus. It is worthwhile to uncover the underlying mechanisms of clinical benefits of human urine‐derived stem cells (hUSCs) in the treatment of DN. At present, the clinical benefits associated with hUSCs in...