Plasma from pre‐eclamptic patients induces the expression of the anti‐angiogenic miR‐195‐5p in endothelial cells
We examined the effect of plasma incubation from preeclampsia pregnant on the antiangiogenic miR‐195‐5p expression. Higher miR‐195‐5p expression was found in cultures incubated with preeclampsia plasma compared to those incubated with healthy pregnant plasma. Next, as VEGF is a target of miR‐195‐5p...
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| Published in | Journal of cellular and molecular medicine Vol. 20; no. 6; pp. 1198 - 1200 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
John Wiley & Sons, Inc
01.06.2016
John Wiley and Sons Inc |
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| Abstract | We examined the effect of plasma incubation from preeclampsia pregnant on the antiangiogenic miR‐195‐5p expression. Higher miR‐195‐5p expression was found in cultures incubated with preeclampsia plasma compared to those incubated with healthy pregnant plasma. Next, as VEGF is a target of miR‐195‐5p we have quantified its expression by real‐time qPCR and ELISA. We found reduced VEGF levels in culture incubated with preeclampsia plasma. Therefore, we have concluded that the higher expression of miR‐195‐5p in endothelial cell cultures incubated with preeclampsia plasma may contribute to decreased expression of VEGFA (gene and protein) and increased antiangiogenic status in preeclampsia. Therefore, this miR may be an important target in preeclampsia. |
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| AbstractList | We examined the effect of plasma incubation from preeclampsia pregnant on the antiangiogenic miR‐195‐5p expression. Higher miR‐195‐5p expression was found in cultures incubated with preeclampsia plasma compared to those incubated with healthy pregnant plasma. Next, as VEGF is a target of miR‐195‐5p we have quantified its expression by real‐time qPCR and ELISA. We found reduced VEGF levels in culture incubated with preeclampsia plasma. Therefore, we have concluded that the higher expression of miR‐195‐5p in endothelial cell cultures incubated with preeclampsia plasma may contribute to decreased expression of VEGFA (gene and protein) and increased antiangiogenic status in preeclampsia. Therefore, this miR may be an important target in preeclampsia. |
| Author | Sandrim, Valeria Cristina Deffune, Elenice Tanus‐Santos, Jose E Cavalli, Ricardo C. Dias, Mayara Caldeira Bovolato, Ana Lívia de Carvalho |
| AuthorAffiliation | 3 Department of Pharmacology Faculty of Medicine of Ribeirao Preto University of Sao Paulo Ribeirao Preto SP Brazil 2 Blood Transfusion Center Cell Engineering Laboratory Botucatu Medical School São Paulo State University (UNESP) Botucatu SP Brazil 4 Department of Gynecology and Obstetrics Faculty of Medicine of Ribeirao Preto University of Sao Paulo Ribeirao Preto SP Brazil 1 Department of Pharmacology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP) Botucatu SP Brazil |
| AuthorAffiliation_xml | – name: 3 Department of Pharmacology Faculty of Medicine of Ribeirao Preto University of Sao Paulo Ribeirao Preto SP Brazil – name: 4 Department of Gynecology and Obstetrics Faculty of Medicine of Ribeirao Preto University of Sao Paulo Ribeirao Preto SP Brazil – name: 1 Department of Pharmacology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP) Botucatu SP Brazil – name: 2 Blood Transfusion Center Cell Engineering Laboratory Botucatu Medical School São Paulo State University (UNESP) Botucatu SP Brazil |
| Author_xml | – sequence: 1 givenname: Valeria Cristina surname: Sandrim fullname: Sandrim, Valeria Cristina organization: Universidade Estadual Paulista (UNESP) – sequence: 2 givenname: Mayara Caldeira surname: Dias fullname: Dias, Mayara Caldeira organization: Universidade Estadual Paulista (UNESP) – sequence: 3 givenname: Ana Lívia de Carvalho surname: Bovolato fullname: Bovolato, Ana Lívia de Carvalho organization: São Paulo State University (UNESP) – sequence: 4 givenname: Jose E surname: Tanus‐Santos fullname: Tanus‐Santos, Jose E organization: University of Sao Paulo – sequence: 5 givenname: Elenice surname: Deffune fullname: Deffune, Elenice organization: São Paulo State University (UNESP) – sequence: 6 givenname: Ricardo C. surname: Cavalli fullname: Cavalli, Ricardo C. organization: University of Sao Paulo |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27012926$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.bcp.2015.04.012 10.1016/S0952-3278(98)90146-6 10.1055/s-2007-1016248 10.1016/j.ajpath.2013.08.020 10.1111/1471-0528.12016 10.1172/JCI17189 10.1016/j.molmed.2014.11.009 10.1111/micc.12079 10.1186/1477-7827-10-28 10.1016/S0301-2115(01)00412-2 10.1515/CCLM.2009.228 10.1016/j.ajog.2013.03.032 10.1152/physiol.00043.2008 10.1002/hep.26373 |
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| Copyright | 2016 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. 2016. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
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| Keywords | microRNA miR-195 pre-eclampsia VEGF angiogenesis HUVECs |
| Language | English |
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| References | 1998; 16 2009; 47 2009; 24 2013; 58 2015; 95 2013; 209 2015; 21 2001; 99 2013; 183 2003; 111 2012; 10 2012; 119 2014; 21 1998; 58 e_1_2_7_6_1 e_1_2_7_5_1 e_1_2_7_4_1 e_1_2_7_3_1 e_1_2_7_9_1 e_1_2_7_8_1 e_1_2_7_7_1 e_1_2_7_2_1 e_1_2_7_15_1 e_1_2_7_14_1 e_1_2_7_13_1 e_1_2_7_12_1 e_1_2_7_11_1 e_1_2_7_10_1 25541377 - Trends Mol Med. 2015 Feb;21(2):88-97 9578145 - Prostaglandins Leukot Essent Fatty Acids. 1998 Feb;58(2):91-7 22510585 - Reprod Biol Endocrinol. 2012 Apr 18;10:28 9654603 - Semin Reprod Endocrinol. 1998;16(1):5-15 23545163 - Am J Obstet Gynecol. 2013 Jul;209(1):44.e1-6 19509125 - Physiology (Bethesda). 2009 Jun;24:147-58 25916268 - Biochem Pharmacol. 2015 Jun 15;95(4):211-26 24120378 - Am J Pathol. 2013 Dec;183(6):1993-2006 23468064 - Hepatology. 2013 Aug;58(2):642-53 11788166 - Eur J Obstet Gynecol Reprod Biol. 2001 Dec 1;99(2):172-8 23890192 - Microcirculation. 2014 Jan;21(1):4-14 12618519 - J Clin Invest. 2003 Mar;111(5):649-58 23121125 - BJOG. 2012 Dec;119(13):1564-71 19642860 - Clin Chem Lab Med. 2009;47(8):923-9 |
| References_xml | – volume: 99 start-page: 172 year: 2001 end-page: 8 article-title: Production of vasoactive substances by human umbilical vein endothelial cells after incubation with serum from preeclamptic patients publication-title: Eur J Obstet Gynecol Reprod Biol – volume: 209 start-page: 44.e1 year: 2013 end-page: 6 article-title: Progesterone blunts vascular endothelial cell secretion of endothelin‐1 in response to placental ischemia publication-title: Am J Obstet Gynecol – volume: 47 start-page: 923 year: 2009 end-page: 9 article-title: Differential expression of microRNAs in the placentae of Chinese patients with severe pre‐eclampsia publication-title: Clin Chem Lab Med – volume: 183 start-page: 1993 year: 2013 end-page: 2006 article-title: Preeclamptic plasma induces transcription modifications involving the AP‐1 transcriptional regulator JDP2 in endothelial cells publication-title: Am J Pathol – volume: 58 start-page: 91 year: 1998 end-page: 7 article-title: Eicosanoid secretion by human endothelial cells exposed to normal pregnancy and preeclampsia plasma publication-title: Prostaglandins Leukot Essent Fatty Acids – volume: 24 start-page: 147 year: 2009 end-page: 58 article-title: Preeclampsia: the role of angiogenic factors in its pathogenesis publication-title: Physiology (Bethesda) – volume: 16 start-page: 5 year: 1998 end-page: 15 article-title: Endothelial dysfunction in preeclampsia publication-title: Semin Reprod Endocrinol – volume: 58 start-page: 642 year: 2013 end-page: 53 article-title: MicroRNA‐195 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting the expression of VEGF, VAV2, and CDC42 publication-title: Hepatology – volume: 10 start-page: 28 year: 2012 article-title: Preeclampsia serum upregulates CD40/CD40L expression and induces apoptosis in human umbilical cord endothelial cells publication-title: Reprod Biol Endocrinol – volume: 95 start-page: 211 year: 2015 end-page: 26 article-title: Bioactive factors in uteroplacental and systemic circulation link placental ischemia to generalized vascular dysfunction in hypertensive pregnancy and preeclampsia publication-title: Biochem Pharmacol – volume: 21 start-page: 88 year: 2015 end-page: 97 article-title: Molecular mechanisms of maternal vascular dysfunction in preeclampsia publication-title: Trends Mol Med – volume: 119 start-page: 1564 year: 2012 article-title: Endothelial Fos expression and preeclampsia publication-title: BJOG – volume: 111 start-page: 649 year: 2003 end-page: 58 article-title: Excess placental soluble fms‐like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia publication-title: J Clin Invest – volume: 21 start-page: 4 year: 2014 end-page: 14 article-title: Vascular dysfunction in preeclampsia publication-title: Microcirculation – ident: e_1_2_7_5_1 doi: 10.1016/j.bcp.2015.04.012 – ident: e_1_2_7_12_1 doi: 10.1016/S0952-3278(98)90146-6 – ident: e_1_2_7_7_1 doi: 10.1055/s-2007-1016248 – ident: e_1_2_7_11_1 doi: 10.1016/j.ajpath.2013.08.020 – ident: e_1_2_7_10_1 doi: 10.1111/1471-0528.12016 – ident: e_1_2_7_6_1 doi: 10.1172/JCI17189 – ident: e_1_2_7_9_1 doi: 10.1016/j.molmed.2014.11.009 – ident: e_1_2_7_8_1 doi: 10.1111/micc.12079 – ident: e_1_2_7_13_1 doi: 10.1186/1477-7827-10-28 – ident: e_1_2_7_14_1 doi: 10.1016/S0301-2115(01)00412-2 – ident: e_1_2_7_4_1 doi: 10.1515/CCLM.2009.228 – ident: e_1_2_7_15_1 doi: 10.1016/j.ajog.2013.03.032 – ident: e_1_2_7_3_1 doi: 10.1152/physiol.00043.2008 – ident: e_1_2_7_2_1 doi: 10.1002/hep.26373 – reference: 9578145 - Prostaglandins Leukot Essent Fatty Acids. 1998 Feb;58(2):91-7 – reference: 23545163 - Am J Obstet Gynecol. 2013 Jul;209(1):44.e1-6 – reference: 19509125 - Physiology (Bethesda). 2009 Jun;24:147-58 – reference: 19642860 - Clin Chem Lab Med. 2009;47(8):923-9 – reference: 11788166 - Eur J Obstet Gynecol Reprod Biol. 2001 Dec 1;99(2):172-8 – reference: 24120378 - Am J Pathol. 2013 Dec;183(6):1993-2006 – reference: 23890192 - Microcirculation. 2014 Jan;21(1):4-14 – reference: 25541377 - Trends Mol Med. 2015 Feb;21(2):88-97 – reference: 12618519 - J Clin Invest. 2003 Mar;111(5):649-58 – reference: 23121125 - BJOG. 2012 Dec;119(13):1564-71 – reference: 25916268 - Biochem Pharmacol. 2015 Jun 15;95(4):211-26 – reference: 9654603 - Semin Reprod Endocrinol. 1998;16(1):5-15 – reference: 22510585 - Reprod Biol Endocrinol. 2012 Apr 18;10:28 – reference: 23468064 - Hepatology. 2013 Aug;58(2):642-53 |
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| Snippet | We examined the effect of plasma incubation from preeclampsia pregnant on the antiangiogenic miR‐195‐5p expression. Higher miR‐195‐5p expression was found in... We examined the effect of plasma incubation from preeclampsia pregnant on the antiangiogenic miR-195-5p expression. Higher miR-195-5p expression was found in... |
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| SubjectTerms | Adult Angiogenesis Angiogenesis Inhibitors - metabolism Cell culture Endothelial cells Enzyme-linked immunosorbent assay Female Gene expression Gene Expression Regulation Human Umbilical Vein Endothelial Cells - metabolism Humans HUVECs Kinases Liver cancer microRNA MicroRNAs - genetics MicroRNAs - metabolism miR‐195 Neovascularization, Physiologic Plasma Pre-eclampsia Pre-Eclampsia - blood Preeclampsia Pregnancy Proteins Short Communication Short Communications Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism VEGF |
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| Title | Plasma from pre‐eclamptic patients induces the expression of the anti‐angiogenic miR‐195‐5p in endothelial cells |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fjcmm.12767 https://www.ncbi.nlm.nih.gov/pubmed/27012926 https://www.proquest.com/docview/2290216429 https://www.proquest.com/docview/1792370807 https://pubmed.ncbi.nlm.nih.gov/PMC4882987 |
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