A randomized, controlled trial of negative pressure wound therapy of pressure ulcers via a novel polyurethane foam

The objectives of the study were (1) to look for any local, clinically apparent response, within and around a debrided wound, to a novel biocompatible polyurethane foam during repeated, short‐term implantation, and (2) to assess the material's efficacy as a negative pressure wound therapy (NPWT...

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Published inWound repair and regeneration Vol. 22; no. 2; pp. 205 - 211
Main Authors Wagstaff, Marcus James Dermot, Driver, Sara, Coghlan, Patrick, Greenwood, John Edward
Format Journal Article
LanguageEnglish
Published United States Blackwell Publishing Ltd 01.03.2014
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Abstract The objectives of the study were (1) to look for any local, clinically apparent response, within and around a debrided wound, to a novel biocompatible polyurethane foam during repeated, short‐term implantation, and (2) to assess the material's efficacy as a negative pressure wound therapy (NPWT) interface compared with a widely used, commercially available foam. Twenty pressure ulcers in 18 patients underwent surgical debridement, then randomization to receive novel treatment or control foam as the wound interface for NPWT. Dressing changes every 2–3 days allowed qualitative wound assessment and quantitative measurement to compare outcomes. No adverse reaction was observed in any patient receiving the new foam. The new “novel foam” performed as a NPWT interface as effectively as the control “standard foam.” In deep wounds, the new foam was easier to remove, fragmented less, and showed less retention than the control foam. No marginal in‐growth occurred, making removal less traumatic and reducing bleeding from cavity wall granulations. The results support previous large animal studies, and independent ISO10993 testing, that the new foam is safe and biocompatible. Its efficacy as an NPWT interface, nontraumatic removal with low fragmentation and retention rate, favors the new material, especially in deep cavity wounds.
AbstractList The objectives of the study were (1) to look for any local, clinically apparent response, within and around a debrided wound, to a novel biocompatible polyurethane foam during repeated, short-term implantation, and (2) to assess the material's efficacy as a negative pressure wound therapy (NPWT) interface compared with a widely used, commercially available foam. Twenty pressure ulcers in 18 patients underwent surgical debridement, then randomization to receive novel treatment or control foam as the wound interface for NPWT. Dressing changes every 2-3 days allowed qualitative wound assessment and quantitative measurement to compare outcomes. No adverse reaction was observed in any patient receiving the new foam. The new "novel foam" performed as a NPWT interface as effectively as the control "standard foam." In deep wounds, the new foam was easier to remove, fragmented less, and showed less retention than the control foam. No marginal in-growth occurred, making removal less traumatic and reducing bleeding from cavity wall granulations. The results support previous large animal studies, and independent ISO10993 testing, that the new foam is safe and biocompatible. Its efficacy as an NPWT interface, nontraumatic removal with low fragmentation and retention rate, favors the new material, especially in deep cavity wounds.
The objectives of the study were (1) to look for any local, clinically apparent response, within and around a debrided wound, to a novel biocompatible polyurethane foam during repeated, short‐term implantation, and (2) to assess the material's efficacy as a negative pressure wound therapy ( NPWT ) interface compared with a widely used, commercially available foam. Twenty pressure ulcers in 18 patients underwent surgical debridement, then randomization to receive novel treatment or control foam as the wound interface for NPWT . Dressing changes every 2–3 days allowed qualitative wound assessment and quantitative measurement to compare outcomes. No adverse reaction was observed in any patient receiving the new foam. The new “novel foam” performed as a NPWT interface as effectively as the control “standard foam.” In deep wounds, the new foam was easier to remove, fragmented less, and showed less retention than the control foam. No marginal in‐growth occurred, making removal less traumatic and reducing bleeding from cavity wall granulations. The results support previous large animal studies, and independent ISO 10993 testing, that the new foam is safe and biocompatible. Its efficacy as an NPWT interface, nontraumatic removal with low fragmentation and retention rate, favors the new material, especially in deep cavity wounds.
Author Coghlan, Patrick
Wagstaff, Marcus James Dermot
Driver, Sara
Greenwood, John Edward
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  surname: Wagstaff
  fullname: Wagstaff, Marcus James Dermot
  organization: Department of Plastic and Reconstructive Surgery, Royal Adelaide Hospital, South Australia, Adelaide, Australia
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  organization: Adult Burn Centre, Royal Adelaide Hospital, South Australia, Adelaide, Australia
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SubjectTerms Adolescent
Adult
Aged
Bandages
Biocompatible Materials - therapeutic use
Female
Follow-Up Studies
Granulation Tissue - pathology
Humans
Male
Middle Aged
Molecular Sequence Data
Negative-Pressure Wound Therapy - methods
Pain Measurement
Pilot Projects
Polyurethanes - therapeutic use
Pressure Ulcer - pathology
Pressure Ulcer - physiopathology
Pressure Ulcer - therapy
Time Factors
Treatment Outcome
Wound Healing
Title A randomized, controlled trial of negative pressure wound therapy of pressure ulcers via a novel polyurethane foam
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