A dynamic metabolic flux balance based model of fed-batch fermentation of bordetella pertussis

• Published in: Biotechnology progress Vol. 29; no. 2; pp. 520 - 531
• Main Authors: Budman, Hector, Patel, Nilesh, Tamer, Melih, Al-Gherwi, Walid
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.03.2013
• Subjects: Batch Cell Culture Techniques; Bioreactors - microbiology; Bordetella pertussis; Bordetella pertussis - chemistry; Bordetella pertussis - growth & development; Bordetella pertussis - metabolism; Carbon - metabolism; dynamic metabolic flux model; Fermentation; Glucose - metabolism; Kinetics; Models, Theoretical; Tyrosine - metabolism
• ISSN: 8756-7938; 1520-6033; 1520-6033
• DOI: 10.1002/btpr.1675

A mathematical model based on a dynamic metabolic flux balance (DMFB) is developed for a process of fed‐batch fermentation of Bordetella pertussis. The model is based on the maximization of growth rate at each time interval subject to stoichiometric constraints. The model is calibrated and verified...