Protective effect of wogonin on inflammatory responses in BisGMA‐treated macrophages through the inhibition of MAPK and NFκB pathways

• Published in: Environmental toxicology Vol. 37; no. 12; pp. 3007 - 3012
• Main Authors: Yang, Li‐Chiu, Chang, Yu‐Chao, Chiang, Chen‐Yu, Huang, Fu‐Mei, Su, Ni‐Yu, Kuan, Yu‐Hsiang
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.12.2022; Wiley Subscription Services, Inc
• Subjects: anti-allergic agents; anti-inflammatory agents; Anticancer properties; BisGMA; Bisphenol A glycidyl methacrylate; Cytokines; Degradation; Dentistry; ecotoxicology; Extracellular signal-regulated kinase; Flavonoids; inducible nitric oxide synthase; Inflammation; Interleukin 6; Interleukins; JNK protein; Kinases; macrophage; Macrophages; MAP kinase; mitogen-activated protein kinase; Necrosis; NF-κB protein; Nitric oxide; Nitric-oxide synthase; Orthopedics; Phosphorylation; Polymer matrix composites; proinflammatory cytokines; propane; protective effect; Protein kinase; Resins; Rutin; Sealants; signal transduction; Tumor necrosis factor; Tumor necrosis factor-TNF; tumor necrosis factors; Upstream; wogonin

Composites, resins, and sealants that are commonly used in orthopedics and dentistry are based on 2,2‐bis[p‐(2′‐hydroxy‐3′‐methacryloxypropoxy)phenylene]propane (BisGMA), which induces proinflammatory responses in macrophages. The present study aimed to explore the anti‐inflammatory responses of wog...