Hepcidin resistance in dysmetabolic iron overload

• Published in: Liver international Vol. 36; no. 10; pp. 1540 - 1548
• Main Authors: Rametta, Raffaela, Dongiovanni, Paola, Pelusi, Serena, Francione, Paolo, Iuculano, Federica, Borroni, Vittorio, Fatta, Erika, Castagna, Annalisa, Girelli, Domenico, Fargion, Silvia, Valenti, Luca
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.10.2016
• Subjects: Adult; Aged; Case-Control Studies; Female; Ferritins - blood; Hemochromatosis - complications; Hemoglobins - metabolism; Hepcidins - blood; Hepcidins - metabolism; hereditary haemochromatosis; Humans; iron; Iron - metabolism; Iron Overload - metabolism; Iron Overload - physiopathology; Italy; Linear Models; liver; Liver - pathology; Male; Middle Aged; Non-alcoholic Fatty Liver Disease - complications; nonalcoholic fatty liver disease; Young Adult; iron; nonalcoholic fatty liver disease; liver; hereditary haemochromatosis

Background & Aims Dysmetabolic iron overload syndrome (DIOS) is a frequent condition predisposing to metabolic, cardiovascular and hepatic damage, whose pathogenesis remains poorly defined. Aim of this study was to characterize iron metabolism in DIOS. Methods We evaluated 18 patients with DIOS,...