Combined melatonin and exendin-4 therapy preserves renal ultrastructural integrity after ischemia-reperfusion injury in the male rat

• Published in: Journal of pineal research Vol. 59; no. 4; pp. 434 - 447
• Main Authors: Yip, Hon-Kan, Yang, Chih-Chao, Chen, Kuan-Hung, Huang, Tien-Hung, Chen, Yi-Ling, Zhen, Yen-Yi, Sung, Pei-Hsun, Chiang, Hsin-Ju, Sheu, Jiunn-Jye, Chang, Chia-Lo, Chen, Chih-Hung, Chang, Hsueh-Wen, Chen, Yen-Ta
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.11.2015
• Subjects: Animals; Cadherins - metabolism; Calcium-Binding Proteins - metabolism; Cell Adhesion Molecules - metabolism; exendin-4; ischemia-reperfusion; Kidney - drug effects; Kidney - metabolism; kidney ultrastructure; Male; Matrix Metalloproteinase 9 - metabolism; melatonin; Melatonin - therapeutic use; NF-kappa B - metabolism; Oxidative Stress - drug effects; Peptides - therapeutic use; podocyte; Podocytes - drug effects; Podocytes - metabolism; Rats; Rats, Sprague-Dawley; Reperfusion Injury - drug therapy; Reperfusion Injury - metabolism; Tumor Necrosis Factor-alpha - metabolism; Venoms - therapeutic use; WT1 Proteins - metabolism; ischemia-reperfusion; melatonin; exendin-4; kidney ultrastructure; podocyte

We tested whether combined melatonin (Mel) and exendin‐4 (Ex4) treatment can better preserve glomerular structural integrity after ischemia–reperfusion (IR) injury compared with either alone. Adult male Sprague Dawley rats (n = 50) were equally divided into sham control (SC), IR, IR‐Ex4 (10 μg/kg su...