Differential Plasma Proteins Identified via iTRAQ-Based Analysis Serve as Diagnostic Markers of Pancreatic Ductal Adenocarcinoma

• Published in: Disease markers Vol. 2023; pp. 5145152 - 11
• Main Authors: Chen, Xiubing, Liao, Xiaomin, Zheng, Biaolin, Wang, Feng, Chen, Feiran, Deng, Zhejun, Jiang, Haixing, Qin, Shanyu
• Format: Journal Article
• Language: English
• Published: United States Hindawi 2023; Hindawi Limited
• Subjects: Adenocarcinoma; Antigens; Biomarkers; Biomarkers, Tumor - metabolism; Biotechnology; Blood Proteins; Body mass index; CA-19-9 Antigen; Cancer; Carbohydrates; Carcinoma, Pancreatic Ductal - diagnosis; Carcinoma, Pancreatic Ductal - pathology; Diagnostic systems; Enzyme-linked immunosorbent assay; Growth factors; GTP-binding protein; Hemoglobin; Humans; Immunoglobulins; Insulin; Insulin-like growth factor-binding protein 2; Laboratories; Mass spectrometry; Pancreatic cancer; Pancreatic Neoplasms; Pancreatic Neoplasms - pathology; Peptides; Peroxiredoxin; Plasma; Plasma proteins; Proteins; Scientific imaging; Sialyl Lewis a antigen; Software; Beijing China; United States > US; Massachusetts; China

Objective. We aimed to identify differentially expressed proteins in the plasma of patients with pancreatic cancer and control subjects, which could serve as potential tumor biomarkers. Methods. Differentially expressed proteins were determined via isostatic labeling and absolute quantification (iTR...