Long-term late toxicities and quality of life for survivors of nasopharyngeal carcinoma treated with intensity-modulated radiotherapy versus non-intensity-modulated radiotherapy

Background The purpose of this study was to investigate late toxicities and quality of life (QOL) of patients with nasopharyngeal carcinoma (NPC) with long‐term survival after treatment by intensity‐modulated radiotherapy (IMRT) versus non‐IMRT. Methods An observational, cross‐sectional study of QOL...

Full description

Saved in:

Bibliographic Details
Published in	Head & neck Vol. 38; no. S1; pp. E1026 - E1032
Main Authors	Huang, Tai-Lin, Chien, Chih-Yen, Tsai, Wen-Ling, Liao, Kuan-Cho, Chou, Shang-Yu, Lin, Hsin-Ching, Dean Luo, Sheng, Lee, Tsair-Fwu, Lee, Chien-Hung, Fang, Fu-Min
Format	Journal Article
Language	English
Published	United States Blackwell Publishing Ltd 01.04.2016
Subjects	Adolescent Adult Aged Carcinoma - radiotherapy Cross-Sectional Studies European Organization for Research and Treatment of Cancer (EORTC) Female Humans intensity-modulated radiotherapy late toxicity Male Middle Aged Nasopharyngeal Carcinoma Nasopharyngeal Neoplasms - radiotherapy Quality of Life Radiotherapy, Intensity-Modulated Survivors Young Adult intensity-modulated radiotherapy nasopharyngeal carcinoma quality of life European Organization for Research and Treatment of Cancer (EORTC) late toxicity
Online Access	Get full text

Cover

Loading…

Abstract	Background The purpose of this study was to investigate late toxicities and quality of life (QOL) of patients with nasopharyngeal carcinoma (NPC) with long‐term survival after treatment by intensity‐modulated radiotherapy (IMRT) versus non‐IMRT. Methods An observational, cross‐sectional study of QOL and late toxicities was conducted in 242 patients with NPC with survival of >5 years after treatment with IMRT (n = 100) or non‐IMRT (n = 142) by using physician‐assessed toxicities (Common Terminology Criteria for Adverse Events [CTCAE] version 4) and the patient‐reported European Organization for Research and Treatment of Cancer Quality of Life Questionnaire‐Core 30‐questions (EORTC QLQ‐C30) and the Head and Neck 35‐questions (EORTC QLQ‐C30‐H&N35) module. Results The IMRT group had both statistically (p < .05) and clinically (difference of predicted mean scores ≥10 points) better outcome in global QOL, cognitive functioning, social functioning, fatigue, and 11 scales of the head and neck module. Late toxicities, including neuropathy, hearing loss, dysphagia, xerostomia, and neck fibrosis were significantly less severe in the IMRT group. Multivariate analysis revealed that the radiotherapy (RT) technique was statistically significantly associated with late toxicities and QOL outcome after adjusting for other clinical and demographic variables. Conclusion The use of the IMRT technique was associated with the improvement of physician‐assessed late toxicities and patient‐reported QOL in NPC survivors. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1026–E1032, 2016
AbstractList	Background The purpose of this study was to investigate late toxicities and quality of life (QOL) of patients with nasopharyngeal carcinoma (NPC) with long‐term survival after treatment by intensity‐modulated radiotherapy (IMRT) versus non‐IMRT. Methods An observational, cross‐sectional study of QOL and late toxicities was conducted in 242 patients with NPC with survival of >5 years after treatment with IMRT (n = 100) or non‐IMRT (n = 142) by using physician‐assessed toxicities (Common Terminology Criteria for Adverse Events [CTCAE] version 4) and the patient‐reported European Organization for Research and Treatment of Cancer Quality of Life Questionnaire‐Core 30‐questions (EORTC QLQ‐C30) and the Head and Neck 35‐questions (EORTC QLQ‐C30‐H&N35) module. Results The IMRT group had both statistically (p < .05) and clinically (difference of predicted mean scores ≥10 points) better outcome in global QOL, cognitive functioning, social functioning, fatigue, and 11 scales of the head and neck module. Late toxicities, including neuropathy, hearing loss, dysphagia, xerostomia, and neck fibrosis were significantly less severe in the IMRT group. Multivariate analysis revealed that the radiotherapy (RT) technique was statistically significantly associated with late toxicities and QOL outcome after adjusting for other clinical and demographic variables. Conclusion The use of the IMRT technique was associated with the improvement of physician‐assessed late toxicities and patient‐reported QOL in NPC survivors. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1026–E1032, 2016 The purpose of this study was to investigate late toxicities and quality of life (QOL) of patients with nasopharyngeal carcinoma (NPC) with long-term survival after treatment by intensity-modulated radiotherapy (IMRT) versus non-IMRT. An observational, cross-sectional study of QOL and late toxicities was conducted in 242 patients with NPC with survival of >5 years after treatment with IMRT (n = 100) or non-IMRT (n = 142) by using physician-assessed toxicities (Common Terminology Criteria for Adverse Events [CTCAE] version 4) and the patient-reported European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30-questions (EORTC QLQ-C30) and the Head and Neck 35-questions (EORTC QLQ-C30-H&N35) module. The IMRT group had both statistically (p < .05) and clinically (difference of predicted mean scores ≥10 points) better outcome in global QOL, cognitive functioning, social functioning, fatigue, and 11 scales of the head and neck module. Late toxicities, including neuropathy, hearing loss, dysphagia, xerostomia, and neck fibrosis were significantly less severe in the IMRT group. Multivariate analysis revealed that the radiotherapy (RT) technique was statistically significantly associated with late toxicities and QOL outcome after adjusting for other clinical and demographic variables. The use of the IMRT technique was associated with the improvement of physician-assessed late toxicities and patient-reported QOL in NPC survivors. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1026-E1032, 2016.
Author	Dean Luo, Sheng Huang, Tai-Lin Chien, Chih-Yen Tsai, Wen-Ling Liao, Kuan-Cho Lin, Hsin-Ching Lee, Chien-Hung Fang, Fu-Min Chou, Shang-Yu Lee, Tsair-Fwu
Author_xml	– sequence: 1 givenname: Tai-Lin surname: Huang fullname: Huang, Tai-Lin organization: Department of Hematology and Oncology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan – sequence: 2 givenname: Chih-Yen surname: Chien fullname: Chien, Chih-Yen organization: Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan – sequence: 3 givenname: Wen-Ling surname: Tsai fullname: Tsai, Wen-Ling organization: Department of Cosmetics and Fashion Styling, Cheng Shiu University, Kaohsiung, Taiwan – sequence: 4 givenname: Kuan-Cho surname: Liao fullname: Liao, Kuan-Cho organization: Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan – sequence: 5 givenname: Shang-Yu surname: Chou fullname: Chou, Shang-Yu organization: Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan – sequence: 6 givenname: Hsin-Ching surname: Lin fullname: Lin, Hsin-Ching organization: Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan – sequence: 7 givenname: Sheng surname: Dean Luo fullname: Dean Luo, Sheng organization: Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan – sequence: 8 givenname: Tsair-Fwu surname: Lee fullname: Lee, Tsair-Fwu organization: Department of Electronics Engineering, National Kaohsiung University of Applied Sciences, Kaohsiung, Taiwan – sequence: 9 givenname: Chien-Hung surname: Lee fullname: Lee, Chien-Hung organization: Department of Public Health, College of Health Science, Kaohsiung Medical University, Kaohsiung, Taiwan – sequence: 10 givenname: Fu-Min surname: Fang fullname: Fang, Fu-Min email: fang2569@gmail.com organization: Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/26041548$$D View this record in MEDLINE/PubMed
BookMark	eNqFkc1uFDEQhC0URH7gwAsgXzk48Yw9f0cIIYm0CgqCcLR67Z6sYcbe2J5N9rF4Q7zZLAcE4tRW-6uSuuqQ7DnvkJDXBT8uOC9PFmiOS1lU_Bk5KHjXMC5ks7d5S8EEb-Q-OYzxO-dc1LJ8QfbLmmdctgfk58y7W5YwjHSAhDT5B6ttshgpOEPvJhhsWlPf08H2SHsfaJzCyq58iJutg-iXCwhrd4swUA1BW-dHoClg9jP03qYFtS6hi9mIjd5Mw-NHAGN9WmCA5ZquMMQp0nwX-x_7kjzvYYj46mkeka8fz76cXrDZp_PL03czpkUtOBNCi0qDbKqiMBLFvJ0LFDkdWc9laUqoqw7aqtFc68oUHbZgqrKGjnd9W3IQR-TN1nc5zUc0ahnsmO9Uu-wycLIFdPAxBuxVDg6S9S4FsIMquNq0o3I76rGdrHj7h2Jn-jf2yf3eDrj-N6guzj7sFGyrsDHhw28FhB-qbkRTqW9X5-r6s3h_c93eqE78AigHsx0
CitedBy_id	crossref_primary_10_18632_oncotarget_17582 crossref_primary_10_1002_jmrs_145 crossref_primary_10_3390_jpm14091013 crossref_primary_10_1002_hed_25177 crossref_primary_10_1016_j_tranon_2021_101216 crossref_primary_10_1016_j_tranon_2020_100765 crossref_primary_10_1016_j_oraloncology_2022_106261 crossref_primary_10_1186_s13014_020_01490_x crossref_primary_10_1093_jrr_rrz036 crossref_primary_10_1002_hed_26941 crossref_primary_10_1186_s12906_018_2124_x crossref_primary_10_1016_j_ijrobp_2018_05_060 crossref_primary_10_1016_j_oraloncology_2017_12_004 crossref_primary_10_1186_s40880_017_0245_0 crossref_primary_10_3390_cancers13205063 crossref_primary_10_3390_ijerph17103519 crossref_primary_10_1007_s00520_024_08412_7 crossref_primary_10_1016_j_canrad_2022_12_001 crossref_primary_10_1002_lio2_365 crossref_primary_10_1016_j_oraloncology_2021_105494 crossref_primary_10_2512_jspm_17_87 crossref_primary_10_2174_1871527319666200708125741 crossref_primary_10_1016_j_radonc_2022_11_012 crossref_primary_10_1002_hed_26634 crossref_primary_10_1007_s00432_019_03067_y crossref_primary_10_1044_2019_AJSLP_19_0116 crossref_primary_10_1002_cac2_12082 crossref_primary_10_3390_cancers13194802 crossref_primary_10_3390_curroncol30010076 crossref_primary_10_1016_j_canrad_2020_07_004 crossref_primary_10_1097_AUD_0000000000000346 crossref_primary_10_1016_j_ijrobp_2018_09_015 crossref_primary_10_3390_cancers14010225 crossref_primary_10_1186_s13014_018_0990_5 crossref_primary_10_1016_j_adro_2019_07_015 crossref_primary_10_1016_j_adro_2017_05_002 crossref_primary_10_1016_j_ejon_2017_10_006 crossref_primary_10_1186_s13014_022_02105_3 crossref_primary_10_1002_cam4_6723 crossref_primary_10_1007_s00520_023_07750_2 crossref_primary_10_1016_j_oraloncology_2018_04_025 crossref_primary_10_12677_ACM_2023_132263 crossref_primary_10_18632_oncotarget_14932 crossref_primary_10_14639_0392_100X_N2223 crossref_primary_10_62610_RJOR_2024_2_16_63 crossref_primary_10_3390_cancers16183237 crossref_primary_10_1016_j_annonc_2020_12_007 crossref_primary_10_1155_2019_4094395 crossref_primary_10_1016_j_radonc_2023_109743 crossref_primary_10_1007_s00520_019_04920_z crossref_primary_10_3390_cancers14051109 crossref_primary_10_1007_s12094_018_1988_z crossref_primary_10_3389_fonc_2021_628919 crossref_primary_10_1002_hed_27785 crossref_primary_10_1002_lary_31974 crossref_primary_10_1186_s13014_023_02331_3 crossref_primary_10_3389_fonc_2020_00930 crossref_primary_10_3389_fmed_2022_828370 crossref_primary_10_1177_11795549211036898 crossref_primary_10_3389_fonc_2021_653050
Cites_doi	10.1046/j.1365-2753.2001.00298.x 10.1200/JCO.1999.17.3.1008 10.1016/S0167-8140(01)00449-2 10.1023/A:1022070220328 10.1016/j.ijrobp.2010.03.024 10.1016/j.ijrobp.2006.06.013 10.1002/cncr.22396 10.1016/j.ijrobp.2011.11.026 10.1007/s11136-006-9113-0 10.1016/j.ijrobp.2006.04.033 10.1016/j.radonc.2007.07.009 10.1016/j.radonc.2009.09.013 10.1200/JCO.2008.19.9109 10.1016/j.radonc.2004.06.005 10.1016/j.ijrobp.2005.05.057 10.1111/j.1365-2842.2004.01383.x 10.1016/S0895-4356(00)00312-7 10.1016/j.radonc.2010.05.022 10.1016/j.ijrobp.2004.11.002 10.1016/j.ijrobp.2011.12.040 10.1016/j.ijrobp.2006.11.012 10.1002/cncr.1554 10.1002/hed.20378 10.1200/JCO.2007.14.6647 10.1016/j.ijrobp.2005.02.045 10.1038/bjc.2013.720 10.1016/j.radonc.2012.08.013 10.1016/j.radonc.2004.11.004 10.1200/JCO.2007.14.8841 10.1002/(SICI)1097-0142(20000315)88:6<1294::AID-CNCR4>3.0.CO;2-M 10.1016/j.ijrobp.2008.05.023 10.1093/jnci/85.5.365 10.1016/S0360-3016(00)01389-4 10.1200/JCO.1998.16.1.139 10.1016/j.ijrobp.2008.02.061
ContentType	Journal Article
Copyright	2015 Wiley Periodicals, Inc.
Copyright_xml	– notice: 2015 Wiley Periodicals, Inc.
DBID	BSCLL AAYXX CITATION CGR CUY CVF ECM EIF NPM
DOI	10.1002/hed.24150
DatabaseName	Istex CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid)
DatabaseTitleList	MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database
DeliveryMethod	fulltext_linktorsrc
EISSN	1097-0347
EndPage	E1032
ExternalDocumentID	26041548 10_1002_hed_24150 HED24150 ark_67375_WNG_QR3BVQ8V_9
Genre	article Journal Article Observational Study
GrantInformation_xml	– fundername: Chang Gung Memorial Hospital, Taiwan funderid: CMRPG8A0201; CMRPG8A0202; CMRPG8C1141
GroupedDBID	--- .3N .55 .GA .Y3 05W 0R~ 10A 1L6 1OB 1OC 1ZS 31~ 33P 36B 3O- 3SF 3WU 4.4 4ZD 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHHS AANLZ AAONW AASGY AAXRX AAZKR ABCQN ABCUV ABEML ABIJN ABQWH ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACGFS ACGOF ACMXC ACPOU ACPRK ACSCC ACXBN ACXQS ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADOZA ADZMN ADZOD AEEZP AEIGN AEIMD AEQDE AEUQT AEUYR AFBPY AFFPM AFGKR AFPWT AFZJQ AHBTC AHMBA AIACR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BROTX BRXPI BSCLL BY8 C45 CS3 D-6 D-7 D-E D-F DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DUUFO EBD EBS EJD EMB EMOBN F00 F01 F04 F5P FEDTE G-S G.N GNP GODZA H.X HBH HF~ HGLYW HHY HHZ HVGLF HZ~ IX1 J0M JPC KBYEO KQQ LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES M6P MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ NNB O66 O9- OIG OVD P2W P2X P2Z P4B P4D PALCI PQQKQ Q.N Q11 QB0 QRW R.K RIWAO ROL RWI RX1 RYL SAMSI SUPJJ SV3 TEORI UB1 V2E W8V W99 WBKPD WH7 WHWMO WIH WIJ WIK WJL WOHZO WQJ WRC WUP WVDHM WWO WXI WXSBR X7M XG1 XPP XV2 ZGI ZXP ZZTAW ~IA ~WT AAHQN AAIPD AAMNL AANHP AAYCA ACRPL ACYXJ ADNMO AFWVQ ALVPJ AAYXX AEYWJ AGHNM AGQPQ AGYGG CITATION CGR CUY CVF ECM EIF NPM
ID	FETCH-LOGICAL-c3630-33c35ca47511d4e3b8b3e310946b42d2a659a857c0cc5d19e8ad526a909f820a3
IEDL.DBID	DR2
ISSN	1043-3074
IngestDate	Mon Jul 21 06:04:29 EDT 2025 Thu Apr 24 23:12:30 EDT 2025 Tue Jul 01 03:27:52 EDT 2025 Wed Jan 22 16:56:15 EST 2025 Wed Oct 30 09:52:50 EDT 2024
IsPeerReviewed	true
IsScholarly	true
Issue	S1
Keywords	intensity-modulated radiotherapy nasopharyngeal carcinoma quality of life European Organization for Research and Treatment of Cancer (EORTC) late toxicity
Language	English
License	http://onlinelibrary.wiley.com/termsAndConditions#vor 2015 Wiley Periodicals, Inc.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c3630-33c35ca47511d4e3b8b3e310946b42d2a659a857c0cc5d19e8ad526a909f820a3
Notes	ArticleID:HED24150 istex:017C737D3AD36A0C62CE6006C5EF6FBA368C6C80 ark:/67375/WNG-QR3BVQ8V-9 Chang Gung Memorial Hospital, Taiwan - No. CMRPG8A0201; No. CMRPG8A0202; No. CMRPG8C1141 Tai‐Lin Huang and Chih‐Yen Chien contributed equally to this work.
PMID	26041548
PageCount	7
ParticipantIDs	pubmed_primary_26041548 crossref_citationtrail_10_1002_hed_24150 crossref_primary_10_1002_hed_24150 wiley_primary_10_1002_hed_24150_HED24150 istex_primary_ark_67375_WNG_QR3BVQ8V_9
ProviderPackageCode	CITATION AAYXX
PublicationCentury	2000
PublicationDate	2016-04 April 2016 2016-04-00
PublicationDateYYYYMMDD	2016-04-01
PublicationDate_xml	– month: 04 year: 2016 text: 2016-04
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States
PublicationTitle	Head & neck
PublicationTitleAlternate	Head Neck
PublicationYear	2016
Publisher	Blackwell Publishing Ltd
Publisher_xml	– name: Blackwell Publishing Ltd
References	Lee AW, Ng WT, Hung WM, et al. Major late toxicities after conformal radiotherapy for nasopharyngeal carcinoma-patient- and treatment-related risk factors. Int J Radiat Oncol Biol Phys 2009;73:1121-1128. Fayers P, Aaronson NK, Bjordal K, et al. EORTC QLQ-C30 Scoring Manual 2nd edition. Brussels, Belgium: EORTC Data Center; 1999. Yu CL, Fielding R, Chan CL, Sham JS. Chinese nasopharyngeal carcinoma patients treated with radiotherapy: association between satisfaction with information provided and quality of life. Cancer 2001;92:2126-2135. Jabbari S, Kim HM, Feng M, et al. Matched case-control study of quality of life and xerostomia after intensity-modulated radiotherapy or standard radiotherapy for head-and-neck cancer: initial report. Int J Radiat Oncol Biol Phys 2005;63:725-731. Chen AM, Farwell DG, Luu Q, Vazquez EG, Lau DH, Purdy JA. Intensity-modulated radiotherapy is associated with improved global quality of life among long-term survivors of head-and-neck cancer. Int J Radiat Oncol Biol Phys 2012;84:170-175. McMillan AS, Pow EN, Leung WK, Wong MC, Kwong DL. Oral health-related quality of life in southern Chinese following radiotherapy for nasopharyngeal carcinoma. J Oral Rehabil 2004;31:600-608. Hunt MA, Zelefsky MJ, Wolden S, et al. Treatment planning and delivery of intensity-modulated radiation therapy for primary nasopharynx cancer. Int J Radiat Oncol Biol Phys 2001;49:623-632. Teo PM, Ma BB, Chan AT. Radiotherapy for nasopharyngeal carcinoma-transition from two-dimensional to three-dimensional methods. Radiother Oncol 2004;73:163-172. Teguh DN, Levendag PC, Noever I, et al. Treatment techniques and site considerations regarding dysphagia-related quality of life in cancer of the oropharynx and nasopharynx. Int J Radiat Oncol Biol Phys 2008;72:1119-1127. Middel B, Stewart R, Bouma J, van Sonderen E, van den Heuvel WJ. How to validate clinically important change in health-related functional status. Is the magnitude of the effect size consistently related to magnitude of change as indicated by a global question rating? J Eval Clin Pract 2001;7:399-410. Lai SZ, Li WF, Chen L, et al. How does intensity-modulated radiotherapy versus conventional two-dimensional radiotherapy influence the treatment results in nasopharyngeal carcinoma patients? Int J Radiat Oncol Biol Phys2011;80:661-668. Osoba D, Rodrigues G, Myles J, Zee B, Pater J. Interpreting the significance of changes in health-related quality-of-life scores. J Clin Oncol 1998;16:139-144. Zeng L, Tian YM, Sun XM, et al. Late toxicities after intensity-modulated radiotherapy for nasopharyngeal carcinoma: patient and treatment-related risk factors. Br J Cancer 2014;110:49-54. Yeh SA, Tang Y, Lui CC, Huang YJ, Huang EY. Treatment outcomes and late complications of 849 patients with nasopharyngeal carcinoma treated with radiotherapy alone. Int J Radiat Oncol Biol Phys 2005;62:672-679. Chao KS, Majhail N, Huang CJ, et al. Intensity-modulated radiation therapy reduces late salivary toxicity without compromising tumor control in patients with oropharyngeal carcinoma: a comparison with conventional techniques. Radiother Oncol 2001;61:275-280. Levendag PC, Teguh DN, Voet P, et al. Dysphagia disorders in patients with cancer of the oropharynx are significantly affected by the radiation therapy dose to the superior and middle constrictor muscle: a dose-effect relationship. Radiother Oncol 2007;85:64-73. Lee N, Harris J, Garden AS, et al. Intensity-modulated radiation therapy with or without chemotherapy for nasopharyngeal carcinoma: radiation therapy oncology group phase II trial 0225. J Clin Oncol 2009;27:3684-3690. Langendijk JA, Doornaert P, Verdonck-de Leeuw IM, Leemans CR, Aaronson NK, Slotman BJ. Impact of late treatment-related toxicity on quality of life among patients with head and neck cancer treated with radiotherapy. J Clin Oncol 2008;26:3770-3776. Wang SZ, Li J, Miyamoto CT, et al. A study of middle ear function in the treatment of nasopharyngeal carcinoma with IMRT technique. Radiother Oncol 2009;93:530-533. Graff P, Lapeyre M, Desandes E, et al. Impact of intensity-modulated radiotherapy on health-related quality of life for head and neck cancer patients: matched-pair comparison with conventional radiotherapy. Int J Radiat Oncol Biol Phys 2007;67:1309-1317. Fang FM, Tsai WL, Lee TF, Liao KC, Chen HC, Hsu HC. Multivariate analysis of quality of life outcome for nasopharyngeal carcinoma patients after treatment. Radiother Oncol 2010;97:263-269. Machtay M, Moughan J, Trotti A, et al. Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: an RTOG analysis. J Clin Oncol 2008;26:3582-3589. Peng G, Wang T, Yang KY, et al. A prospective, randomized study comparing outcomes and toxicities of intensity-modulated radiotherapy vs. conventional two-dimensional radiotherapy for the treatment of nasopharyngeal carcinoma. Radiother Oncol 2012;104:286-293. Hsiung CY, Ting HM, Huang HY, Lee CH, Huang EY, Hsu HC. Parotid-sparing intensity-modulated radiotherapy (IMRT) for nasopharyngeal carcinoma: preserved parotid function after IMRT on quantitative salivary scintigraphy, and comparison with historical data after conventional radiotherapy. Int J Radiat Oncol Biol Phys 2006;66:454-461. Aronson NK, Ahmedzai S, Bergman B, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 1993;85:365-376. Fang FM, Tsai WL, Chen HC, et al. Intensity-modulated or conformal radiotherapy improves quality of life of patients with nasopharyngeal carcinoma: comparisons of four radiotherapy techniques. Cancer 2007;109:311-321. Jang-Chun L, Jing-Min H, Yee-Min J, et al. Comparisons of quality of life for patients with nasopharyngeal carcinoma after treatment with different RT technologies. Acta Otorhinolaryngol Ital 2014;34:241-246. Pow EH, Kwong DL, Sham JS, Lee VH, Ng SC. Can intensity-modulated radiotherapy preserve oral health-related quality of life of nasopharyngeal carcinoma patients? Int J Radiat Oncol Biol Phys 2012;83:e213-e221. Ramsey SD, Andersen MR, Etzioni R, et al. Quality of life in survivors of colorectal carcinoma. Cancer 2000;88:1294-1303. Chie WC, Hong RL, Lai CC, Ting LL, Hsu MM. Quality of life in patients of nasopharyngeal carcinoma: validation of the Taiwan Chinese version of the EORTC QLQ-C30 and the EORTC QLQ-H&N35. Qual Life Res 2003;12:93-98. McMillan AS, Pow EH, Kwong DL, et al. Preservation of quality of life after intensity-modulated radiotherapy for early-stage nasopharyngeal carcinoma: results of a prospective longitudinal study. Head Neck 2006;28:712-722. Bjordal K, Hammerlid E, Ahlner-Elmqvist M, et al. Quality of life in head and neck cancer patients: validation of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-H&N35. J Clin Oncol 1999;17:1008-1019. Wu Y, Hu WH, Xia YF, Ma J, Liu MZ, Cui NJ. Quality of life of nasopharyngeal carcinoma survivors in Mainland China. Qual Life Res 2007;16:65-74. Pow EH, Kwong DL, McMillan AS, et al. Xerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: initial report on a randomized controlled clinical trial. Int J Radiat Oncol Biol Phys 2006;66:981-991. Cengiz M, Ozyar E, Esassolak M, et al. Assessment of quality of life of nasopharyngeal carcinoma patients with EORTC QLQ-C30 and H&N-35 modules. Int J Radiat Oncol Biol Phys 2005;63:1347-1353. Saarilahti K, Kouri M, Collan J, et al. Intensity modulated radiotherapy for head and neck cancer: evidence for preserved salivary gland function. Radiother Oncol 2005;74:251-258. Penson DF, Stoddard ML, Pasta DJ, Lubeck DP, Flanders SC, Litwin MS. The association between socioeconomic status, health insurance coverage, and quality of life in men with prostate cancer. J Clin Epidemiol 2001;54:350-358. 2012; 83 2001; 92 2010; 97 2011; 80 2000; 88 1993; 85 2005; 62 2005; 63 2001; 49 2008; 72 2014; 110 2012; 104 2007; 109 2009; 27 2003; 12 1999 2007; 16 1998; 16 2001; 61 2004; 31 2004; 73 2009; 73 2001; 7 2006; 66 2009; 93 1999; 17 2006; 28 2005; 74 2008; 26 2007; 85 2007; 67 2014; 34 2012; 84 2001; 54 e_1_2_5_27_1 e_1_2_5_28_1 e_1_2_5_25_1 e_1_2_5_26_1 e_1_2_5_23_1 e_1_2_5_24_1 Fayers P (e_1_2_5_16_1) 1999 e_1_2_5_21_1 e_1_2_5_22_1 e_1_2_5_29_1 e_1_2_5_20_1 e_1_2_5_15_1 e_1_2_5_38_1 e_1_2_5_14_1 e_1_2_5_39_1 e_1_2_5_17_1 e_1_2_5_36_1 e_1_2_5_9_1 e_1_2_5_37_1 e_1_2_5_8_1 e_1_2_5_11_1 Jang‐Chun L (e_1_2_5_31_1) 2014; 34 e_1_2_5_34_1 e_1_2_5_7_1 e_1_2_5_10_1 e_1_2_5_35_1 e_1_2_5_6_1 e_1_2_5_13_1 e_1_2_5_32_1 e_1_2_5_5_1 e_1_2_5_12_1 e_1_2_5_33_1 e_1_2_5_4_1 e_1_2_5_3_1 e_1_2_5_2_1 e_1_2_5_19_1 e_1_2_5_18_1 e_1_2_5_30_1
References_xml	– reference: Hsiung CY, Ting HM, Huang HY, Lee CH, Huang EY, Hsu HC. Parotid-sparing intensity-modulated radiotherapy (IMRT) for nasopharyngeal carcinoma: preserved parotid function after IMRT on quantitative salivary scintigraphy, and comparison with historical data after conventional radiotherapy. Int J Radiat Oncol Biol Phys 2006;66:454-461. – reference: Wu Y, Hu WH, Xia YF, Ma J, Liu MZ, Cui NJ. Quality of life of nasopharyngeal carcinoma survivors in Mainland China. Qual Life Res 2007;16:65-74. – reference: Zeng L, Tian YM, Sun XM, et al. Late toxicities after intensity-modulated radiotherapy for nasopharyngeal carcinoma: patient and treatment-related risk factors. Br J Cancer 2014;110:49-54. – reference: Saarilahti K, Kouri M, Collan J, et al. Intensity modulated radiotherapy for head and neck cancer: evidence for preserved salivary gland function. Radiother Oncol 2005;74:251-258. – reference: Hunt MA, Zelefsky MJ, Wolden S, et al. Treatment planning and delivery of intensity-modulated radiation therapy for primary nasopharynx cancer. Int J Radiat Oncol Biol Phys 2001;49:623-632. – reference: Chen AM, Farwell DG, Luu Q, Vazquez EG, Lau DH, Purdy JA. Intensity-modulated radiotherapy is associated with improved global quality of life among long-term survivors of head-and-neck cancer. Int J Radiat Oncol Biol Phys 2012;84:170-175. – reference: Chie WC, Hong RL, Lai CC, Ting LL, Hsu MM. Quality of life in patients of nasopharyngeal carcinoma: validation of the Taiwan Chinese version of the EORTC QLQ-C30 and the EORTC QLQ-H&N35. Qual Life Res 2003;12:93-98. – reference: Wang SZ, Li J, Miyamoto CT, et al. A study of middle ear function in the treatment of nasopharyngeal carcinoma with IMRT technique. Radiother Oncol 2009;93:530-533. – reference: Teguh DN, Levendag PC, Noever I, et al. Treatment techniques and site considerations regarding dysphagia-related quality of life in cancer of the oropharynx and nasopharynx. Int J Radiat Oncol Biol Phys 2008;72:1119-1127. – reference: Pow EH, Kwong DL, McMillan AS, et al. Xerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: initial report on a randomized controlled clinical trial. Int J Radiat Oncol Biol Phys 2006;66:981-991. – reference: McMillan AS, Pow EN, Leung WK, Wong MC, Kwong DL. Oral health-related quality of life in southern Chinese following radiotherapy for nasopharyngeal carcinoma. J Oral Rehabil 2004;31:600-608. – reference: Teo PM, Ma BB, Chan AT. Radiotherapy for nasopharyngeal carcinoma-transition from two-dimensional to three-dimensional methods. Radiother Oncol 2004;73:163-172. – reference: McMillan AS, Pow EH, Kwong DL, et al. Preservation of quality of life after intensity-modulated radiotherapy for early-stage nasopharyngeal carcinoma: results of a prospective longitudinal study. Head Neck 2006;28:712-722. – reference: Ramsey SD, Andersen MR, Etzioni R, et al. Quality of life in survivors of colorectal carcinoma. Cancer 2000;88:1294-1303. – reference: Machtay M, Moughan J, Trotti A, et al. Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: an RTOG analysis. J Clin Oncol 2008;26:3582-3589. – reference: Yeh SA, Tang Y, Lui CC, Huang YJ, Huang EY. Treatment outcomes and late complications of 849 patients with nasopharyngeal carcinoma treated with radiotherapy alone. Int J Radiat Oncol Biol Phys 2005;62:672-679. – reference: Fang FM, Tsai WL, Chen HC, et al. Intensity-modulated or conformal radiotherapy improves quality of life of patients with nasopharyngeal carcinoma: comparisons of four radiotherapy techniques. Cancer 2007;109:311-321. – reference: Middel B, Stewart R, Bouma J, van Sonderen E, van den Heuvel WJ. How to validate clinically important change in health-related functional status. Is the magnitude of the effect size consistently related to magnitude of change as indicated by a global question rating? J Eval Clin Pract 2001;7:399-410. – reference: Yu CL, Fielding R, Chan CL, Sham JS. Chinese nasopharyngeal carcinoma patients treated with radiotherapy: association between satisfaction with information provided and quality of life. Cancer 2001;92:2126-2135. – reference: Penson DF, Stoddard ML, Pasta DJ, Lubeck DP, Flanders SC, Litwin MS. The association between socioeconomic status, health insurance coverage, and quality of life in men with prostate cancer. J Clin Epidemiol 2001;54:350-358. – reference: Fang FM, Tsai WL, Lee TF, Liao KC, Chen HC, Hsu HC. Multivariate analysis of quality of life outcome for nasopharyngeal carcinoma patients after treatment. Radiother Oncol 2010;97:263-269. – reference: Aronson NK, Ahmedzai S, Bergman B, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 1993;85:365-376. – reference: Levendag PC, Teguh DN, Voet P, et al. Dysphagia disorders in patients with cancer of the oropharynx are significantly affected by the radiation therapy dose to the superior and middle constrictor muscle: a dose-effect relationship. Radiother Oncol 2007;85:64-73. – reference: Lai SZ, Li WF, Chen L, et al. How does intensity-modulated radiotherapy versus conventional two-dimensional radiotherapy influence the treatment results in nasopharyngeal carcinoma patients? Int J Radiat Oncol Biol Phys2011;80:661-668. – reference: Peng G, Wang T, Yang KY, et al. A prospective, randomized study comparing outcomes and toxicities of intensity-modulated radiotherapy vs. conventional two-dimensional radiotherapy for the treatment of nasopharyngeal carcinoma. Radiother Oncol 2012;104:286-293. – reference: Graff P, Lapeyre M, Desandes E, et al. Impact of intensity-modulated radiotherapy on health-related quality of life for head and neck cancer patients: matched-pair comparison with conventional radiotherapy. Int J Radiat Oncol Biol Phys 2007;67:1309-1317. – reference: Jang-Chun L, Jing-Min H, Yee-Min J, et al. Comparisons of quality of life for patients with nasopharyngeal carcinoma after treatment with different RT technologies. Acta Otorhinolaryngol Ital 2014;34:241-246. – reference: Chao KS, Majhail N, Huang CJ, et al. Intensity-modulated radiation therapy reduces late salivary toxicity without compromising tumor control in patients with oropharyngeal carcinoma: a comparison with conventional techniques. Radiother Oncol 2001;61:275-280. – reference: Pow EH, Kwong DL, Sham JS, Lee VH, Ng SC. Can intensity-modulated radiotherapy preserve oral health-related quality of life of nasopharyngeal carcinoma patients? Int J Radiat Oncol Biol Phys 2012;83:e213-e221. – reference: Langendijk JA, Doornaert P, Verdonck-de Leeuw IM, Leemans CR, Aaronson NK, Slotman BJ. Impact of late treatment-related toxicity on quality of life among patients with head and neck cancer treated with radiotherapy. J Clin Oncol 2008;26:3770-3776. – reference: Cengiz M, Ozyar E, Esassolak M, et al. Assessment of quality of life of nasopharyngeal carcinoma patients with EORTC QLQ-C30 and H&N-35 modules. Int J Radiat Oncol Biol Phys 2005;63:1347-1353. – reference: Fayers P, Aaronson NK, Bjordal K, et al. EORTC QLQ-C30 Scoring Manual 2nd edition. Brussels, Belgium: EORTC Data Center; 1999. – reference: Bjordal K, Hammerlid E, Ahlner-Elmqvist M, et al. Quality of life in head and neck cancer patients: validation of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-H&N35. J Clin Oncol 1999;17:1008-1019. – reference: Lee N, Harris J, Garden AS, et al. Intensity-modulated radiation therapy with or without chemotherapy for nasopharyngeal carcinoma: radiation therapy oncology group phase II trial 0225. J Clin Oncol 2009;27:3684-3690. – reference: Jabbari S, Kim HM, Feng M, et al. Matched case-control study of quality of life and xerostomia after intensity-modulated radiotherapy or standard radiotherapy for head-and-neck cancer: initial report. Int J Radiat Oncol Biol Phys 2005;63:725-731. – reference: Osoba D, Rodrigues G, Myles J, Zee B, Pater J. Interpreting the significance of changes in health-related quality-of-life scores. J Clin Oncol 1998;16:139-144. – reference: Lee AW, Ng WT, Hung WM, et al. Major late toxicities after conformal radiotherapy for nasopharyngeal carcinoma-patient- and treatment-related risk factors. Int J Radiat Oncol Biol Phys 2009;73:1121-1128. – volume: 31 start-page: 600 year: 2004 end-page: 608 article-title: Oral health‐related quality of life in southern Chinese following radiotherapy for nasopharyngeal carcinoma publication-title: J Oral Rehabil – volume: 73 start-page: 1121 year: 2009 end-page: 1128 article-title: Major late toxicities after conformal radiotherapy for nasopharyngeal carcinoma‐patient‐ and treatment‐related risk factors publication-title: Int J Radiat Oncol Biol Phys – volume: 88 start-page: 1294 year: 2000 end-page: 1303 article-title: Quality of life in survivors of colorectal carcinoma publication-title: Cancer – volume: 17 start-page: 1008 year: 1999 end-page: 1019 article-title: Quality of life in head and neck cancer patients: validation of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire‐H&N35 publication-title: J Clin Oncol – volume: 28 start-page: 712 year: 2006 end-page: 722 article-title: Preservation of quality of life after intensity‐modulated radiotherapy for early‐stage nasopharyngeal carcinoma: results of a prospective longitudinal study publication-title: Head Neck – volume: 66 start-page: 454 year: 2006 end-page: 461 article-title: Parotid‐sparing intensity‐modulated radiotherapy (IMRT) for nasopharyngeal carcinoma: preserved parotid function after IMRT on quantitative salivary scintigraphy, and comparison with historical data after conventional radiotherapy publication-title: Int J Radiat Oncol Biol Phys – volume: 54 start-page: 350 year: 2001 end-page: 358 article-title: The association between socioeconomic status, health insurance coverage, and quality of life in men with prostate cancer publication-title: J Clin Epidemiol – volume: 85 start-page: 64 year: 2007 end-page: 73 article-title: Dysphagia disorders in patients with cancer of the oropharynx are significantly affected by the radiation therapy dose to the superior and middle constrictor muscle: a dose‐effect relationship publication-title: Radiother Oncol – volume: 83 start-page: e213 year: 2012 end-page: e221 article-title: Can intensity‐modulated radiotherapy preserve oral health‐related quality of life of nasopharyngeal carcinoma patients? publication-title: Int J Radiat Oncol Biol Phys – volume: 62 start-page: 672 year: 2005 end-page: 679 article-title: Treatment outcomes and late complications of 849 patients with nasopharyngeal carcinoma treated with radiotherapy alone publication-title: Int J Radiat Oncol Biol Phys – volume: 63 start-page: 725 year: 2005 end-page: 731 article-title: Matched case‐control study of quality of life and xerostomia after intensity‐modulated radiotherapy or standard radiotherapy for head‐and‐neck cancer: initial report publication-title: Int J Radiat Oncol Biol Phys – volume: 63 start-page: 1347 year: 2005 end-page: 1353 article-title: Assessment of quality of life of nasopharyngeal carcinoma patients with EORTC QLQ‐C30 and H&N‐35 modules publication-title: Int J Radiat Oncol Biol Phys – volume: 26 start-page: 3770 year: 2008 end-page: 3776 article-title: Impact of late treatment‐related toxicity on quality of life among patients with head and neck cancer treated with radiotherapy publication-title: J Clin Oncol – volume: 7 start-page: 399 year: 2001 end-page: 410 article-title: How to validate clinically important change in health‐related functional status. Is the magnitude of the effect size consistently related to magnitude of change as indicated by a global question rating? publication-title: J Eval Clin Pract – volume: 93 start-page: 530 year: 2009 end-page: 533 article-title: A study of middle ear function in the treatment of nasopharyngeal carcinoma with IMRT technique publication-title: Radiother Oncol – volume: 26 start-page: 3582 year: 2008 end-page: 3589 article-title: Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: an RTOG analysis publication-title: J Clin Oncol – volume: 72 start-page: 1119 year: 2008 end-page: 1127 article-title: Treatment techniques and site considerations regarding dysphagia‐related quality of life in cancer of the oropharynx and nasopharynx publication-title: Int J Radiat Oncol Biol Phys – volume: 104 start-page: 286 year: 2012 end-page: 293 article-title: A prospective, randomized study comparing outcomes and toxicities of intensity‐modulated radiotherapy vs. conventional two‐dimensional radiotherapy for the treatment of nasopharyngeal carcinoma publication-title: Radiother Oncol – volume: 49 start-page: 623 year: 2001 end-page: 632 article-title: Treatment planning and delivery of intensity‐modulated radiation therapy for primary nasopharynx cancer publication-title: Int J Radiat Oncol Biol Phys – volume: 110 start-page: 49 year: 2014 end-page: 54 article-title: Late toxicities after intensity‐modulated radiotherapy for nasopharyngeal carcinoma: patient and treatment‐related risk factors publication-title: Br J Cancer – volume: 67 start-page: 1309 year: 2007 end-page: 1317 article-title: Impact of intensity‐modulated radiotherapy on health‐related quality of life for head and neck cancer patients: matched‐pair comparison with conventional radiotherapy publication-title: Int J Radiat Oncol Biol Phys – volume: 27 start-page: 3684 year: 2009 end-page: 3690 article-title: Intensity‐modulated radiation therapy with or without chemotherapy for nasopharyngeal carcinoma: radiation therapy oncology group phase II trial 0225 publication-title: J Clin Oncol – volume: 80 start-page: 661 year: 2011 end-page: 668 article-title: How does intensity‐modulated radiotherapy versus conventional two‐dimensional radiotherapy influence the treatment results in nasopharyngeal carcinoma patients? publication-title: Int J Radiat Oncol Biol Phys – volume: 12 start-page: 93 year: 2003 end-page: 98 article-title: Quality of life in patients of nasopharyngeal carcinoma: validation of the Taiwan Chinese version of the EORTC QLQ‐C30 and the EORTC QLQ‐H&N35 publication-title: Qual Life Res – volume: 85 start-page: 365 year: 1993 end-page: 376 article-title: The European Organization for Research and Treatment of Cancer QLQ‐C30: a quality‐of‐life instrument for use in international clinical trials in oncology publication-title: J Natl Cancer Inst – volume: 61 start-page: 275 year: 2001 end-page: 280 article-title: Intensity‐modulated radiation therapy reduces late salivary toxicity without compromising tumor control in patients with oropharyngeal carcinoma: a comparison with conventional techniques publication-title: Radiother Oncol – volume: 92 start-page: 2126 year: 2001 end-page: 2135 article-title: Chinese nasopharyngeal carcinoma patients treated with radiotherapy: association between satisfaction with information provided and quality of life publication-title: Cancer – volume: 16 start-page: 139 year: 1998 end-page: 144 article-title: Interpreting the significance of changes in health‐related quality‐of‐life scores publication-title: J Clin Oncol – volume: 34 start-page: 241 year: 2014 end-page: 246 article-title: Comparisons of quality of life for patients with nasopharyngeal carcinoma after treatment with different RT technologies publication-title: Acta Otorhinolaryngol Ital – volume: 73 start-page: 163 year: 2004 end-page: 172 article-title: Radiotherapy for nasopharyngeal carcinoma–transition from two‐dimensional to three‐dimensional methods publication-title: Radiother Oncol – volume: 74 start-page: 251 year: 2005 end-page: 258 article-title: Intensity modulated radiotherapy for head and neck cancer: evidence for preserved salivary gland function publication-title: Radiother Oncol – volume: 16 start-page: 65 year: 2007 end-page: 74 article-title: Quality of life of nasopharyngeal carcinoma survivors in Mainland China publication-title: Qual Life Res – volume: 97 start-page: 263 year: 2010 end-page: 269 article-title: Multivariate analysis of quality of life outcome for nasopharyngeal carcinoma patients after treatment publication-title: Radiother Oncol – volume: 84 start-page: 170 year: 2012 end-page: 175 article-title: Intensity‐modulated radiotherapy is associated with improved global quality of life among long‐term survivors of head‐and‐neck cancer publication-title: Int J Radiat Oncol Biol Phys – volume: 109 start-page: 311 year: 2007 end-page: 321 article-title: Intensity‐modulated or conformal radiotherapy improves quality of life of patients with nasopharyngeal carcinoma: comparisons of four radiotherapy techniques publication-title: Cancer – volume: 66 start-page: 981 year: 2006 end-page: 991 article-title: Xerostomia and quality of life after intensity‐modulated radiotherapy vs. conventional radiotherapy for early‐stage nasopharyngeal carcinoma: initial report on a randomized controlled clinical trial publication-title: Int J Radiat Oncol Biol Phys – year: 1999 – ident: e_1_2_5_18_1 doi: 10.1046/j.1365-2753.2001.00298.x – ident: e_1_2_5_14_1 doi: 10.1200/JCO.1999.17.3.1008 – volume: 34 start-page: 241 year: 2014 ident: e_1_2_5_31_1 article-title: Comparisons of quality of life for patients with nasopharyngeal carcinoma after treatment with different RT technologies publication-title: Acta Otorhinolaryngol Ital – ident: e_1_2_5_3_1 doi: 10.1016/S0167-8140(01)00449-2 – ident: e_1_2_5_15_1 doi: 10.1023/A:1022070220328 – ident: e_1_2_5_7_1 doi: 10.1016/j.ijrobp.2010.03.024 – ident: e_1_2_5_27_1 doi: 10.1016/j.ijrobp.2006.06.013 – ident: e_1_2_5_6_1 doi: 10.1002/cncr.22396 – ident: e_1_2_5_28_1 doi: 10.1016/j.ijrobp.2011.11.026 – ident: e_1_2_5_35_1 doi: 10.1007/s11136-006-9113-0 – ident: e_1_2_5_12_1 doi: 10.1016/j.ijrobp.2006.04.033 – ident: e_1_2_5_22_1 doi: 10.1016/j.radonc.2007.07.009 – ident: e_1_2_5_21_1 doi: 10.1016/j.radonc.2009.09.013 – ident: e_1_2_5_20_1 doi: 10.1200/JCO.2008.19.9109 – ident: e_1_2_5_2_1 doi: 10.1016/j.radonc.2004.06.005 – ident: e_1_2_5_32_1 doi: 10.1016/j.ijrobp.2005.05.057 – ident: e_1_2_5_34_1 doi: 10.1111/j.1365-2842.2004.01383.x – ident: e_1_2_5_38_1 doi: 10.1016/S0895-4356(00)00312-7 – ident: e_1_2_5_36_1 doi: 10.1016/j.radonc.2010.05.022 – ident: e_1_2_5_26_1 doi: 10.1016/j.ijrobp.2004.11.002 – ident: e_1_2_5_19_1 doi: 10.1016/j.ijrobp.2011.12.040 – ident: e_1_2_5_29_1 doi: 10.1016/j.ijrobp.2006.11.012 – ident: e_1_2_5_37_1 doi: 10.1002/cncr.1554 – ident: e_1_2_5_5_1 doi: 10.1002/hed.20378 – ident: e_1_2_5_10_1 doi: 10.1200/JCO.2007.14.6647 – ident: e_1_2_5_30_1 doi: 10.1016/j.ijrobp.2005.02.045 – ident: e_1_2_5_24_1 doi: 10.1038/bjc.2013.720 – ident: e_1_2_5_8_1 doi: 10.1016/j.radonc.2012.08.013 – volume-title: EORTC QLQ‐C30 Scoring Manual 2nd edition year: 1999 ident: e_1_2_5_16_1 – ident: e_1_2_5_33_1 doi: 10.1002/cncr.1554 – ident: e_1_2_5_4_1 doi: 10.1016/j.radonc.2004.11.004 – ident: e_1_2_5_9_1 doi: 10.1200/JCO.2007.14.8841 – ident: e_1_2_5_39_1 doi: 10.1002/(SICI)1097-0142(20000315)88:6<1294::AID-CNCR4>3.0.CO;2-M – ident: e_1_2_5_11_1 doi: 10.1016/j.ijrobp.2008.05.023 – ident: e_1_2_5_13_1 doi: 10.1093/jnci/85.5.365 – ident: e_1_2_5_25_1 doi: 10.1016/S0360-3016(00)01389-4 – ident: e_1_2_5_17_1 doi: 10.1200/JCO.1998.16.1.139 – ident: e_1_2_5_23_1 doi: 10.1016/j.ijrobp.2008.02.061
SSID	ssj0003642
Score	2.4349165
Snippet	Background The purpose of this study was to investigate late toxicities and quality of life (QOL) of patients with nasopharyngeal carcinoma (NPC) with... The purpose of this study was to investigate late toxicities and quality of life (QOL) of patients with nasopharyngeal carcinoma (NPC) with long-term survival...
SourceID	pubmed crossref wiley istex
SourceType	Index Database Enrichment Source Publisher
StartPage	E1026
SubjectTerms	Adolescent Adult Aged Carcinoma - radiotherapy Cross-Sectional Studies European Organization for Research and Treatment of Cancer (EORTC) Female Humans intensity-modulated radiotherapy late toxicity Male Middle Aged Nasopharyngeal Carcinoma Nasopharyngeal Neoplasms - radiotherapy Quality of Life Radiotherapy, Intensity-Modulated Survivors Young Adult
Title	Long-term late toxicities and quality of life for survivors of nasopharyngeal carcinoma treated with intensity-modulated radiotherapy versus non-intensity-modulated radiotherapy
URI	https://api.istex.fr/ark:/67375/WNG-QR3BVQ8V-9/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fhed.24150 https://www.ncbi.nlm.nih.gov/pubmed/26041548
Volume	38
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELaqcuHCQ7y2PGRVCHHJdje2s7E48WhZIajUipYekKKxY5dVtwnazaIup_4EJH4Nf6e_pDP2bloQCMQtSiaK44zH30xmvmHssZM6F877RHlwiQTbT7TVaeJcQBtWKk_VyO-2s-GefHOgDlbYs2UtTOSHaANutDKCvaYFDma6cUEa-smVXdp-yF-nXC0CRLsX1FEik_FPpxQUX5FLVqFeutHe-dNedIWm9eTSRnQZrIbdZus6-7gcZ0wyOerOGtO1X3-hcPzPF7nBri1QKH8e1eYmW3HVLfbjbV0dnp1-I2PNx4hBeVOfjGygXOVQlTwWYM557fl45B1HvMunM7Q1X-rJlM5WQE0RcCTVIeJPbqlPUVUfAw_p7K7kFPXlo5g138zxWcd1Sf3D8NIEytGiGmzOKVdkNuVVXZ2dfv-7_G22t7X5_uUwWXR2SKzIBBp-YYWyIAcI90rphMkNBWPR1cyMTMsUMqUhVwPbs1aVfe1yKFWage5pj5AFxB22ikNw9xh3xnjb8-jhA3q20NcgHFpxa3Q6QKwEHfZ0-Y0Lu6A9p-4b4yISNqcFzn8R5r_D1lvRz5Hr43dCT4KitBIwOaLkuIEqPmy_LnZ2xYv9nXy_0B12N2pSK4muoyQPEYcU9OHPDymGm6_Cwdq_i95nVxHMZTGr6AFbbSYz9xABU2MehZVxDsaeGng
linkProvider	Wiley-Blackwell
linkToHtml	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1fb9MwELem7QFe-CP-lW1gIYR4SdfGdhpLvADbKNBV2rSNvSDLsZ2tWpdMbTqtPO0jIPFp-Dr7JNzZbTYQCMRblFwUxzmff3e5-x0hzx2XKXN5Holcu4hr046kkXHknEcbhoscq5G3-kl3j384EAcL5NW8FibwQ9QBN1wZ3l7jAseA9NoVa-iRs03cf8BhX8KO3sicv75zRR7FEh7-dXKGERY-5xVqxWv1rT_tRks4sefXtqLrcNXvN5u3yef5SEOayXFzUmVN8-UXEsf_fZU75NYMiNLXQXPukgVX3CPfe2VxeHnxFe01HQIMpVV5PjCedZXqwtJQgzmlZU6Hg9xRgLx0PAFzc1aOxni20NgXAYZSHAIEpQZbFRXliaY-o91ZioFfOgiJ89UUnnVSWmwhBpdG2g5mBWFTiukikzEtyuLy4tvf5e-Tvc2N3bfdaNbcITIsYWD7mWHCaN4BxGe5Y1maYTwWvM0k47GNdSKkTkXHtIwRti1dqq2IEy1bMgfUotkDsghDcI8IdVmWm1YOTr4G51a3pWYODLnJZNwBuKQb5OX8IyszYz7HBhxDFTibYwXzr_z8N8izWvQ00H38TuiF15RaQo-OMT-uI9Sn_ju1vcPe7G-n-0o2yMOgSrUkeI8cnUQYkleIPz9EdTfW_cHjfxd9Sm50d7d6qve-_3GZ3ARsl4QkoxWyWI0mbhXwU5U98cvkBztlHpQ
linkToPdf	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3bbtNAEF1VrYR44SJu4bpCCPHi1PGuHa94AtIQoES0oqUPSKv1XkrU1K4SBzU89ROQ-Bp-p1_CzG7iFgQC8WbZY3m9np09M545Q8gjy0XOrHNR6pSNuNKdSGiRRNZ6tKF56rAa-e0wG-zw13vp3gp5uqyFCfwQTcANV4a317jAj4xbPyMN_WRNG7cf8NfXeBYL7NvQ2z7jjmIZD786OcMAC1_SCsXJenPrT5vRGs7r8bmd6Dxa9dtN_zL5uBxoyDI5aM_qoq2__MLh-J9vcoVcWsBQ-izozVWyYstr5PtmVe6fnnxFa03HAEJpXR2PtOdcpao0NFRgzmnl6HjkLAXAS6czMDafq8kUz5YKuyLASMp9AKBUY6OisjpU1OezW0Mx7EtHIW2-nsOzDiuDDcTg0kSZ0aIcbE4xWWQ2pWVVnp58-7v8dbLT33j_YhAtWjtEmmUMLD_TLNWKdwHvGW5ZkRcYjQVfMyt4YhKVpULlaVfHWqemI2yuTJpkSsTCAWZR7AZZhSHYW4TaonA6duDiK3BtVUcoZsGM60IkXQBLqkWeLL-x1Avec2y_MZaBsTmRMP_Sz3-LPGxEjwLZx--EHntFaSTU5ACz47qp_DB8Kbe22fPdrXxXiha5GTSpkQTfkaOLCEPy-vDnh8jBRs8f3P530QfkwrteX26-Gr65Qy4CsMtChtFdslpPZvYegKe6uO8XyQ_kTx1D
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Long%E2%80%90term+late+toxicities+and+quality+of+life+for+survivors+of+nasopharyngeal+carcinoma+treated+with+intensity%E2%80%90modulated+radiotherapy+versus+non%E2%80%93intensity%E2%80%90modulated+radiotherapy&rft.jtitle=Head+%26+neck&rft.au=Huang%2C+Tai%E2%80%90Lin&rft.au=Chien%2C+Chih%E2%80%90Yen&rft.au=Tsai%2C+Wen%E2%80%90Ling&rft.au=Liao%2C+Kuan%E2%80%90Cho&rft.date=2016-04-01&rft.issn=1043-3074&rft.eissn=1097-0347&rft.volume=38&rft.issue=S1&rft_id=info:doi/10.1002%2Fhed.24150&rft.externalDBID=n%2Fa&rft.externalDocID=10_1002_hed_24150
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1043-3074&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1043-3074&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1043-3074&client=summon