Glycoxydation promotes vascular damage Via MAPK-ERK/JNK pathways

• Published in: Journal of cellular physiology Vol. 227; no. 11; pp. 3639 - 3647
• Main Authors: de Nigris, Filomena, Rienzo, Monica, Sessa, Marcella, Infante, Teresa, Cesario, Elena, Ignarro, Louis J., Al-Omran, Mohammed, Giordano, Antonio, Palinski, Wulf, Napoli, Claudio
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.11.2012
• Subjects: Animals; Apolipoproteins E - genetics; Apolipoproteins E - metabolism; Cells, Cultured; Coronary Vessels - cytology; Coronary Vessels - metabolism; Diabetes Mellitus, Experimental; Foam Cells - cytology; Foam Cells - metabolism; Humans; Lipoproteins, LDL - metabolism; Lipoproteins, LDL - pharmacology; Macrophages, Peritoneal - metabolism; MAP Kinase Signaling System - drug effects; MAP Kinase Signaling System - genetics; Mice; Mitogen-Activated Protein Kinase Kinases - drug effects; Mitogen-Activated Protein Kinase Kinases - genetics; Muscle, Smooth, Vascular - cytology; Oxidation-Reduction; Phosphorylation; Protein Kinase Inhibitors - pharmacology; Transcription Factor AP-1 - genetics; Transcription Factor AP-1 - metabolism; Tumor Necrosis Factor-alpha - metabolism

Oxidation and glycation enhance foam cell formation via MAPK/JNK in euglycemic and diabetic subjects. Here, we investigated the effects of glycated and oxidized LDL (glc‐oxLDL) on MAPK‐ERK and JNK signaling pathways using human coronary smooth muscle cells. Glc‐oxLDL induced a broad cascade of MAPK/...