Functional research and molecular mechanism of Kainic acid-induced denitrosylation of thioredoxin-1 in rat hippocampus

• Published in: Neurochemistry international Vol. 108; pp. 448 - 456
• Main Authors: Yang, Hongning, Zhao, Ningjun, Lv, Lanxin, Yan, Xianliang, Hu, Shuqun, Xu, Tie
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.09.2017
• Subjects: Animals; Denitrosylation; GluK2 Kainate Receptor; Glutamate receptor 6; Hippocampus - drug effects; Hippocampus - metabolism; Injections, Intraventricular; Kainic Acid - administration & dosage; Kainic Acid - toxicity; Kainite acid; Male; Nitric Oxide Donors - administration & dosage; Nitroso Compounds - metabolism; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid - metabolism; Thioredoxin-1; Thioredoxins - metabolism; Denitrosylation; Glutamate receptor 6; Kainite acid; Thioredoxin-1

Thioredoxin-1 (Trx1) has long been recognized as a redox regulator, and is implicated in the inhibition of cell apoptosis. Trx1 is essential for the maintenance of the S-nitrosylation of molecules in cells. The S-nitrosylation of Trx1 is essential for the physiological function such as preservation...