A common polymorphism decreases LRP1 mRNA stability and is associated with increased plasma factor VIII levels

• Published in: Biochimica et biophysica acta. Molecular basis of disease Vol. 1863; no. 6; pp. 1690 - 1698
• Main Authors: Lee, Jiann-Der, Hsiao, Kuang-Ming, Chang, Pey-Jium, Chen, Chih-Cheng, Kuo, Ya-Wen, Huang, Yen-Chu, Hsu, Huan-Lin, Lin, Ya-Hui, Wu, Chih-Ying, Huang, Ying-Chih, Lee, Meng, Hsu, Chia-Yu, Pan, Yi-Ting, Kuo, Chih-Yu, Lin, Chun-Hsien
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2017
• Subjects: Codon optimality; Factor VIII; Genetic polymorphism; Low density lipoprotein receptor-related protein 1; Messenger RNA stability; Codon optimality; HTN; Messenger RNA stability; LRP1; vWF; Factor VIII; DM; FXa; FX; LDL; ESE; RT-PCR; Genetic polymorphism; SNPs; HepG2; FVIII; AIC; LDLR; BMI; eGFR; NMD; ESS; qRT-PCR; AIS; Low density lipoprotein receptor-related protein 1; FIXa; HSPGs; PVDF; PTCs; hsCRP; PCR

The low-density lipoprotein receptor-related protein 1 (LRP1) gene is associated with increased levels of plasma factor VIII (FVIII). We aimed to explore eight functional genetic LRP1 variants for their potential roles in regulating FVIII levels and acute ischemic stroke (AIS). This genetic associat...