Dimetallic Ru(II) arene complexes appended on bis-salicylaldimine induce cancer cell death and suppress invasion via p53-dependent signaling

• Published in: European journal of medicinal chemistry Vol. 157; pp. 1480 - 1490
• Main Authors: Rahman, Faiz-Ur, Bhatti, Muhammad Zeeshan, Ali, Amjad, Duong, Hong-Quan, Zhang, Yao, Ji, Xinjian, Lin, Yuejian, Wang, Hui, Li, Zhan-Ting, Zhang, Dan-Wei
• Format: Journal Article
• Language: English
• Published: ISSY-LES-MOULINEAUX Elsevier Masson SAS 05.09.2018; Elsevier
• Subjects: Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; bis-Salicylaldimine; Cell Death - drug effects; Cell Line, Tumor; Cell Movement - drug effects; Cell Proliferation - drug effects; Chemistry, Medicinal; Dimetallic complexes; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Life Sciences & Biomedicine; Molecular Structure; Neoplasm Invasiveness - pathology; Neoplasm Invasiveness - prevention & control; Organometallic Compounds - chemical synthesis; Organometallic Compounds - chemistry; Organometallic Compounds - pharmacology; Pharmacology & Pharmacy; Ru(II) anticancer complexes; Ru-(p-cymene); Ru-anticancer complexes; Ruthenium - chemistry; Ruthenium - pharmacology; Science & Technology; Signal Transduction - drug effects; Structure-Activity Relationship; Tumor Suppressor Protein p53 - metabolism; Ru(II) anticancer complexes; Dimetallic complexes; bis-Salicylaldimine; Ru-anticancer complexes; Ru-(p-cymene); ANTIPROLIFERATIVE ACTIVITY; COPPER-COMPLEXES; PHOTODYNAMIC THERAPY; ESCHERICHIA-COLI; CISPLATIN RESISTANCE; IN-VITRO CYTOTOXICITY; ORGANOMETALLIC ANTICANCER COMPLEXES; LIGANDS SYNTHESIS; RUTHENIUM COMPLEXES; MOLECULAR-MECHANISMS

A series of bis-salicylaldimine ligands bearing two ON-donor functions were reacted with dichloro(p-cymene)ruthenium(II) dimer in the presence of base (NaOAc) and a series of four dimetallic Ru(II) arene complexes (Ru(p-cymene))2(bis-salicylaldimine)Cl2 (C1C4) were prepared. These complexes were obt...