Dimetallic Ru(II) arene complexes appended on bis-salicylaldimine induce cancer cell death and suppress invasion via p53-dependent signaling
A series of bis-salicylaldimine ligands bearing two ON-donor functions were reacted with dichloro(p-cymene)ruthenium(II) dimer in the presence of base (NaOAc) and a series of four dimetallic Ru(II) arene complexes (Ru(p-cymene))2(bis-salicylaldimine)Cl2 (C1C4) were prepared. These complexes were obt...
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| Published in | European journal of medicinal chemistry Vol. 157; pp. 1480 - 1490 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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ISSY-LES-MOULINEAUX
Elsevier Masson SAS
05.09.2018
Elsevier |
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| Abstract | A series of bis-salicylaldimine ligands bearing two ON-donor functions were reacted with dichloro(p-cymene)ruthenium(II) dimer in the presence of base (NaOAc) and a series of four dimetallic Ru(II) arene complexes (Ru(p-cymene))2(bis-salicylaldimine)Cl2 (C1C4) were prepared. These complexes were obtained in excellent isolated yields and characterized in detail by using different spectroscopic techniques. The structure of C1 was also determined in solid state by single crystal X-ray analysis. These complexes were studied for their cytotoxic effect against three different types of human cancer cells including hepatocellular carcinoma (HepG2), non-small-cell lung cancer (A549) and breast cancer (MCF-7) cells by MTT assay. These complexes showed considerable cytotoxic effect in all the above-mentioned cell lines that was comparable to the effect of cisplatin. C1 and C2 showed moderate anticancer effect while C3 and C4 showed reasonable cytotoxicity. We found the cytotoxicity was increased in series from C1 to C4 representing the effect of ligand modification from small to bulky group at the amine functionality of the salicylaldimine. We selected C3 and C4 for mechanistic anticancer study in MCF-7 cells. The acridine orange/ethidium bromide and DAPI staining assays of MCF-7 cells treated with Ru(II) complexes showed apoptosis in cancer cells. Similarly, these complexes induced p53 protein expression in MCF-7 cells. Further, increased mRNA levels of p63, p73, PUMA, BAX and NOXA genes were observed in response to the treatment with C3 and C4, while cyclinD1, MMP3 and ID1 gene expression was significantly reduced. We found reduced invasion ability in breast cancer cells treated with C3 and C4. Taken together, we demonstrated that bis-salicylaldimine based dimetallic Ru-(p-cymene) complexes exerts anticancer effects by p53 pathway, suggesting the promising chemotherapeutic potentials of these Ru(II) complexes for the treatment of cancer. This study may further pave for their in depth in vitro or in vivo anticancer investigations.
Dimetallic bis-salicylaldimine based Ru(II) arene complexes (Ru (p-cymene))2 (bis-salicylaldime)Cl2 were prepared and investigated as anticancer agents. Their in vitro cytotoxic effect on cancer cells was comparable to cisplatin. They induced p53, p63 and p73 genes expression and regulated PUMA, BAX and NOXA genes in MCF-7 breast cancer cells. [Display omitted]
•Dimetallic ruthenium complexes.•Single crystal X-ray structure characterization.•Anticancer study of Ru(II) arene complexes.•Genes activation for efficient apoptosis in cancer cell.•p53 activation by Ru(II) complexes. |
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| AbstractList | A series of bis-salicylaldimine ligands bearing two ON-donor functions were reacted with dichloro(p-cymene)ruthenium(II) dimer in the presence of base (NaOAc) and a series of four dimetallic Ru(II) arene complexes (Ru(p-cymene))
(bis-salicylaldimine)Cl
(C1C4) were prepared. These complexes were obtained in excellent isolated yields and characterized in detail by using different spectroscopic techniques. The structure of C1 was also determined in solid state by single crystal X-ray analysis. These complexes were studied for their cytotoxic effect against three different types of human cancer cells including hepatocellular carcinoma (HepG2), non-small-cell lung cancer (A549) and breast cancer (MCF-7) cells by MTT assay. These complexes showed considerable cytotoxic effect in all the above-mentioned cell lines that was comparable to the effect of cisplatin. C1 and C2 showed moderate anticancer effect while C3 and C4 showed reasonable cytotoxicity. We found the cytotoxicity was increased in series from C1 to C4 representing the effect of ligand modification from small to bulky group at the amine functionality of the salicylaldimine. We selected C3 and C4 for mechanistic anticancer study in MCF-7 cells. The acridine orange/ethidium bromide and DAPI staining assays of MCF-7 cells treated with Ru(II) complexes showed apoptosis in cancer cells. Similarly, these complexes induced p53 protein expression in MCF-7 cells. Further, increased mRNA levels of p63, p73, PUMA, BAX and NOXA genes were observed in response to the treatment with C3 and C4, while cyclinD1, MMP3 and ID1 gene expression was significantly reduced. We found reduced invasion ability in breast cancer cells treated with C3 and C4. Taken together, we demonstrated that bis-salicylaldimine based dimetallic Ru-(p-cymene) complexes exerts anticancer effects by p53 pathway, suggesting the promising chemotherapeutic potentials of these Ru(II) complexes for the treatment of cancer. This study may further pave for their in depth in vitro or in vivo anticancer investigations. A series of bis-salicylaldimine ligands bearing two ON-donor functions were reacted with dichloro(p-cymene)ruthenium(II) dimer in the presence of base (NaOAc) and a series of four dimetallic Ru(II) arene complexes (Ru(p-cymene))2(bis-salicylaldimine)Cl2 (C1C4) were prepared. These complexes were obtained in excellent isolated yields and characterized in detail by using different spectroscopic techniques. The structure of C1 was also determined in solid state by single crystal X-ray analysis. These complexes were studied for their cytotoxic effect against three different types of human cancer cells including hepatocellular carcinoma (HepG2), non-small-cell lung cancer (A549) and breast cancer (MCF-7) cells by MTT assay. These complexes showed considerable cytotoxic effect in all the above-mentioned cell lines that was comparable to the effect of cisplatin. C1 and C2 showed moderate anticancer effect while C3 and C4 showed reasonable cytotoxicity. We found the cytotoxicity was increased in series from C1 to C4 representing the effect of ligand modification from small to bulky group at the amine functionality of the salicylaldimine. We selected C3 and C4 for mechanistic anticancer study in MCF-7 cells. The acridine orange/ethidium bromide and DAPI staining assays of MCF-7 cells treated with Ru(II) complexes showed apoptosis in cancer cells. Similarly, these complexes induced p53 protein expression in MCF-7 cells. Further, increased mRNA levels of p63, p73, PUMA, BAX and NOXA genes were observed in response to the treatment with C3 and C4, while cyclinD1, MMP3 and ID1 gene expression was significantly reduced. We found reduced invasion ability in breast cancer cells treated with C3 and C4. Taken together, we demonstrated that bis-salicylaldimine based dimetallic Ru-(p-cymene) complexes exerts anticancer effects by p53 pathway, suggesting the promising chemotherapeutic potentials of these Ru(II) complexes for the treatment of cancer. This study may further pave for their in depth in vitro or in vivo anticancer investigations. Dimetallic bis-salicylaldimine based Ru(II) arene complexes (Ru (p-cymene))2 (bis-salicylaldime)Cl2 were prepared and investigated as anticancer agents. Their in vitro cytotoxic effect on cancer cells was comparable to cisplatin. They induced p53, p63 and p73 genes expression and regulated PUMA, BAX and NOXA genes in MCF-7 breast cancer cells. [Display omitted] •Dimetallic ruthenium complexes.•Single crystal X-ray structure characterization.•Anticancer study of Ru(II) arene complexes.•Genes activation for efficient apoptosis in cancer cell.•p53 activation by Ru(II) complexes. A series of bis-salicylaldimine ligands bearing two ON-donor functions were reacted with dichloro(p-cymene)ruthenium(II) dimer in the presence of base (NaOAc) and a series of four dimetallic Ru(II) arene complexes (Ru(p-cymene))2(bis-salicylaldimine)Cl-2 (C1-C4) were prepared. These complexes were obtained in excellent isolated yields and characterized in detail by using different spectroscopic techniques. The structure of Cl was also determined in solid state by single crystal X-ray analysis. These complexes were studied for their cytotoxic effect against three different types of human cancer cells including hepatocellular carcinoma (HepG2), non-small-cell lung cancer (A549) and breast cancer (MCF-7) cells by MTT assay. These complexes showed considerable cytotoxic effect in all the above-mentioned cell lines that was comparable to the effect of cisplatin. Cl and C2 showed moderate anticancer effect while C3 and C4 showed reasonable cytotoxicity. We found the cytotoxicity was increased in series from Cl to C4 representing the effect of ligand modification from small to bulky group at the amine functionality of the salicylaldimine. We selected C3 and C4 for mechanistic anticancer study in MCF-7 cells. The acridine orange/ethidium bromide and DAPI staining assays of MCF-7 cells treated with Ru(II) complexes showed apoptosis in cancer cells. Similarly, these complexes induced p53 protein expression in MCF-7 cells. Further, increased mRNA levels of p63, p73, PUMA, BAX and NOXA genes were observed in response to the treatment with C3 and C4, while cydinD1, MMP3 and ID1 gene expression was significantly reduced. We found reduced invasion ability in breast cancer cells treated with C3 and C4. Taken together, we demonstrated that bis-salicylaldimine based dimetallic Ru-(p-cymene) complexes exerts anticancer effects by p53 pathway, suggesting the promising chemotherapeutic potentials of these Ru(II) complexes for the treatment of cancer. This study may further pave for their in depth in vitro or in vivo anticancer investigations. (C) 2018 Elsevier Masson SAS. All rights reserved. A series of bis-salicylaldimine ligands bearing two ON-donor functions were reacted with dichloro(p-cymene)ruthenium(II) dimer in the presence of base (NaOAc) and a series of four dimetallic Ru(II) arene complexes (Ru(p-cymene))2(bis-salicylaldimine)Cl2 (C1C4) were prepared. These complexes were obtained in excellent isolated yields and characterized in detail by using different spectroscopic techniques. The structure of C1 was also determined in solid state by single crystal X-ray analysis. These complexes were studied for their cytotoxic effect against three different types of human cancer cells including hepatocellular carcinoma (HepG2), non-small-cell lung cancer (A549) and breast cancer (MCF-7) cells by MTT assay. These complexes showed considerable cytotoxic effect in all the above-mentioned cell lines that was comparable to the effect of cisplatin. C1 and C2 showed moderate anticancer effect while C3 and C4 showed reasonable cytotoxicity. We found the cytotoxicity was increased in series from C1 to C4 representing the effect of ligand modification from small to bulky group at the amine functionality of the salicylaldimine. We selected C3 and C4 for mechanistic anticancer study in MCF-7 cells. The acridine orange/ethidium bromide and DAPI staining assays of MCF-7 cells treated with Ru(II) complexes showed apoptosis in cancer cells. Similarly, these complexes induced p53 protein expression in MCF-7 cells. Further, increased mRNA levels of p63, p73, PUMA, BAX and NOXA genes were observed in response to the treatment with C3 and C4, while cyclinD1, MMP3 and ID1 gene expression was significantly reduced. We found reduced invasion ability in breast cancer cells treated with C3 and C4. Taken together, we demonstrated that bis-salicylaldimine based dimetallic Ru-(p-cymene) complexes exerts anticancer effects by p53 pathway, suggesting the promising chemotherapeutic potentials of these Ru(II) complexes for the treatment of cancer. This study may further pave for their in depth in vitro or in vivo anticancer investigations.A series of bis-salicylaldimine ligands bearing two ON-donor functions were reacted with dichloro(p-cymene)ruthenium(II) dimer in the presence of base (NaOAc) and a series of four dimetallic Ru(II) arene complexes (Ru(p-cymene))2(bis-salicylaldimine)Cl2 (C1C4) were prepared. These complexes were obtained in excellent isolated yields and characterized in detail by using different spectroscopic techniques. The structure of C1 was also determined in solid state by single crystal X-ray analysis. These complexes were studied for their cytotoxic effect against three different types of human cancer cells including hepatocellular carcinoma (HepG2), non-small-cell lung cancer (A549) and breast cancer (MCF-7) cells by MTT assay. These complexes showed considerable cytotoxic effect in all the above-mentioned cell lines that was comparable to the effect of cisplatin. C1 and C2 showed moderate anticancer effect while C3 and C4 showed reasonable cytotoxicity. We found the cytotoxicity was increased in series from C1 to C4 representing the effect of ligand modification from small to bulky group at the amine functionality of the salicylaldimine. We selected C3 and C4 for mechanistic anticancer study in MCF-7 cells. The acridine orange/ethidium bromide and DAPI staining assays of MCF-7 cells treated with Ru(II) complexes showed apoptosis in cancer cells. Similarly, these complexes induced p53 protein expression in MCF-7 cells. Further, increased mRNA levels of p63, p73, PUMA, BAX and NOXA genes were observed in response to the treatment with C3 and C4, while cyclinD1, MMP3 and ID1 gene expression was significantly reduced. We found reduced invasion ability in breast cancer cells treated with C3 and C4. Taken together, we demonstrated that bis-salicylaldimine based dimetallic Ru-(p-cymene) complexes exerts anticancer effects by p53 pathway, suggesting the promising chemotherapeutic potentials of these Ru(II) complexes for the treatment of cancer. This study may further pave for their in depth in vitro or in vivo anticancer investigations. |
| Author | Rahman, Faiz-Ur Zhang, Dan-Wei Ji, Xinjian Li, Zhan-Ting Duong, Hong-Quan Lin, Yuejian Wang, Hui Zhang, Yao Ali, Amjad Bhatti, Muhammad Zeeshan |
| Author_xml | – sequence: 1 givenname: Faiz-Ur orcidid: 0000-0002-4006-8881 surname: Rahman fullname: Rahman, Faiz-Ur organization: Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, China – sequence: 2 givenname: Muhammad Zeeshan orcidid: 0000-0003-0532-0532 surname: Bhatti fullname: Bhatti, Muhammad Zeeshan organization: Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China – sequence: 3 givenname: Amjad surname: Ali fullname: Ali, Amjad organization: Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China – sequence: 4 givenname: Hong-Quan surname: Duong fullname: Duong, Hong-Quan organization: Institute of Research and Development, Duy Tan University, K7/25 Quang Trung, Danang, 550000, Viet Nam – sequence: 5 givenname: Yao surname: Zhang fullname: Zhang, Yao organization: Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, China – sequence: 6 givenname: Xinjian surname: Ji fullname: Ji, Xinjian organization: Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, China – sequence: 7 givenname: Yuejian surname: Lin fullname: Lin, Yuejian organization: Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, China – sequence: 8 givenname: Hui surname: Wang fullname: Wang, Hui email: wanghui@fudan.edu.cn organization: Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, China – sequence: 9 givenname: Zhan-Ting surname: Li fullname: Li, Zhan-Ting organization: Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, China – sequence: 10 givenname: Dan-Wei surname: Zhang fullname: Zhang, Dan-Wei email: zhangdw@fudan.edu.cn organization: Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30282320$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1002/ejic.201600908 10.1371/journal.pone.0064278 10.1016/j.inoche.2011.03.017 10.1016/j.biomaterials.2003.08.040 10.1016/S0021-9258(18)96186-7 10.1038/ncomms7582 10.1073/pnas.0800076105 10.1039/C5SC01753J 10.1021/acs.jmedchem.5b00444 10.1038/sj.bjp.0707405 10.1016/j.jorganchem.2009.11.020 10.1039/c0dt00292e 10.1039/C5CC08682E 10.1038/onc.2011.384 10.1016/j.inoche.2016.02.001 10.1021/jm500455p 10.1016/j.ejmech.2017.04.007 10.1021/ic062419h 10.1016/j.jinorgbio.2009.10.005 10.1021/acs.inorgchem.8b00346 10.1038/205698a0 10.1039/C6DT00294C 10.1021/cr400135x 10.1002/cncr.26472 10.1039/C5DT02101D 10.1021/jm501095r 10.1124/pr.111.005637 10.1016/j.bmcl.2016.04.005 10.1016/j.ejmech.2017.11.044 10.1021/cr00081a013 10.1111/1440-1681.12581 10.1016/j.jinorgbio.2013.10.017 10.1016/j.ijporl.2014.06.007 10.1002/chem.201202482 10.1039/B916860P 10.1039/C4DT03018D 10.1016/j.cbpa.2007.11.013 10.1021/ja307288s 10.1021/jm500566f 10.1016/j.ccr.2013.03.024 10.1039/C7CS00195A 10.1007/s00775-018-1567-3 10.1016/j.jorganchem.2015.10.028 10.1021/jm8013234 10.1016/j.ccr.2009.06.015 10.1136/bmj.282.6281.2003 10.3390/toxins2112490 10.1016/j.ejmech.2016.09.090 10.1016/j.ejmech.2017.03.029 10.1016/j.biochi.2011.07.025 10.1021/ja4045604 10.1039/C6RA18504E 10.1039/C5DT01098E 10.1016/j.bbagen.2016.10.014 10.1002/ange.201507800 10.1038/nrc2167 10.1107/S0108767307043930 10.1016/j.micron.2010.05.001 10.1016/j.jinorgbio.2014.07.009 10.1002/chem.201300889 10.1039/c3sc22349c 10.1021/acs.jmedchem.5b00855 10.2174/138955751610160503003937 10.1016/j.intimp.2018.01.031 10.1351/pac198759020181 10.1021/jm501655t 10.1038/222385a0 10.1039/c5sc01753j 10.1039/b916860p 10.1039/c6ra18504e 10.1007/978-3-642-13185-1_2 10.1039/c5dt01098e 10.1039/c5cc08682e 10.1039/c6dt00294c 10.1039/c5dt02101d 10.1039/c4dt03018d 10.1039/c7cs00195a |
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| Keywords | Ru(II) anticancer complexes Dimetallic complexes bis-Salicylaldimine Ru-anticancer complexes Ru-(p-cymene) ANTIPROLIFERATIVE ACTIVITY COPPER-COMPLEXES PHOTODYNAMIC THERAPY ESCHERICHIA-COLI CISPLATIN RESISTANCE IN-VITRO CYTOTOXICITY ORGANOMETALLIC ANTICANCER COMPLEXES LIGANDS SYNTHESIS RUTHENIUM COMPLEXES MOLECULAR-MECHANISMS |
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| References | Cassells, Stringer, Hutton, Prince, Smith (bib69) 2018; 23 Rosenberg, Vancamp, Grimley, Thomson (bib13) 1967; 242 Xu, Swavey (bib32) 2011; 14 Pizarro, Habtemariam, Sadler (bib51) 2010 Rosenberg, Vancamp, Krigas (bib10) 1965; 205 Singh, Chauhan, Kang (bib27) 2018; 56 Petit, Mwale, Zukor, Catelas, Antoniou, Huk (bib38) 2004; 25 Windsor, Strauss, Kallis, Wood, Whelan (bib23) 2012; 118 Pitchaimani, Charan Raja, Sujatha, Kar Mahapatra, Moon, Anthony (bib65) 2016; 6 Suss-Fink (bib40) 2010; 39 Rahman, Ali, Guo, Zhang, Wang, Li (bib67) 2015; 44 Zeng, Gupta, Chen, Wang, Ji, Chao (bib50) 2017; 46 Castelán-Martínez, Jiménez-Méndez, Rodríguez-Islas, Fierro-Evans, Vázquez-Gómez, Medina-Sansón (bib24) 2014; 78 Chanu, Banerjee, Roy (bib35) 2016; 125 Kilpin, Dyson (bib42) 2013; 4 Frei, Rubbiani, Tubafard, Blacque, Anstaett, Felgentrager (bib46) 2014; 57 Kelland (bib16) 2007; 7 Levi, Dalley (bib22) 1981; 282 Bergamo, Masi, Peacock, Habtemariam, Sadler, Sava (bib53) 2010; 104 Çalık, Ispir, Karabuga, Aslantas (bib62) 2016; 801 Yang, Chen, Liu, Yang, Chen, Zheng (bib28) 2012; 94 Adnan Salim Abu-Surrah, Abdalla (bib5) 2008; 6 Soldevila-Barreda, Romero-Canelon, Habtemariam, Sadler (bib31) 2015; 6 Suntharalingam, Hunt, Duarte, White, Mann, Vilar (bib34) 2012; 18 Dougan, Habtemariam, McHale, Parsons, Sadler (bib58) 2008; 105 Galluzzi, Senovilla, Vitale, Michels, Martins, Kepp (bib2) 2012; 31 Herman, Tanski, Tibbetts, Anderson (bib49) 2008; 47 Potocnjak, Gobin, Domitrovic (bib15) 2018 Rosenberg, Vancamp, Trosko, Mansour (bib11) 1969; 222 Padilla, Rodriguez-Corrales, Donohoe, Winkel, Brewer (bib48) 2016; 52 Miller, Tadagavadi, Ramesh, Reeves (bib14) 2010; 2 Chen, Qin, Qin, Zhou, Li, Li (bib41) 2015; 58 Meier, Novak, Kandioller, Jakupec, Arion, Metzler-Nolte (bib54) 2013; 19 Sgambellone, David, Garner, Dunbar, Turro (bib30) 2013; 135 Sherman, Lippard (bib17) 1987; 87 Munteanu, Suntharalingam (bib29) 2015; 44 Lippert (bib12) 1999 Wang, Qian, Yiu, Sun, Zhu (bib55) 2014; 131 Jadhav, Sinha, Chhabra, Paira (bib60) 2016; 26 Huang, Yu, Zhang, Huang, Chen, Gasser (bib47) 2015; 127 Pan, Li, He, Qiu, Zhou (bib1) 2016; 43 Zhang, Sadler (bib52) 2017; 2017 Bruijnincx, Sadler (bib26) 2008; 12 Fernandez-Gallardo, Elie, Sadhukha, Prabha, Sanau, Rotenberg (bib36) 2015; 6 Santini, Pellei, Gandin, Porchia, Tisato, Marzano (bib7) 2013; 114 Grazul, Budzisz (bib9) 2009; 253 Reedijk (bib18) 1987; 59 Ulukaya, Frame, Cevatemre, Pellacani, Walker, Mann (bib6) 2013; 8 Liu, Tan, Zu, Fu, Meng, Xing (bib19) 2010; 41 García-Berrocal, Nevado, Ramírez-Camacho, Sanz, González-García, Sánchez-Rodríguez (bib21) 2007; 152 Su, Tang, Li (bib56) 2016; 16 Haghdoost, Golbaghi, Létourneau, Patten, Castonguay (bib64) 2017; 132 Bhattacharyya, Sarkar, Dey, Mukherjee (bib39) 2014; 140 Clavel, Păunescu, Nowak-Sliwinska, Griffioen, Scopelliti, Dyson (bib59) 2015; 58 Grozav, Balacescu, Balacescu, Cheminel, Berindan-Neagoe, Therrien (bib44) 2015; 58 Lazarevic, Rilak, Bugarcic (bib37) 2017; 142 Sheldrick (bib70) 2008; 64 Huang, Zhang, Yu, Chen, Wang, Ji (bib43) 2014; 57 Jia, Zhang, Zhang, Ling (bib61) 2016; 66 Wheate, Walker, Craig, Oun (bib4) 2010; 39 Rahman, Bhatti, Ali, Duong, Zhang, Yang (bib71) 2018; 143 Raveendran, Pal (bib63) 2010; 695 Mendoza-Ferri, Hartinger, Mendoza, Groessl, Egger, Eichinger (bib66) 2009; 52 Musumeci, Platella, Riccardi, Merlino, Marzo, Massai (bib20) 2016; 45 Acilan, Cevatemre, Adiguzel, Karakas, Ulukaya, Ribeiro (bib33) 2017; 1861 Cutillas, Yellol, de Haro, Vicente, Rodríguez, Ruiz (bib8) 2013; 257 Rahman, Ali, Guo, Wang, Wang, Li (bib25) 2015; 44 Pierroz, Joshi, Leonidova, Mari, Schur, Ott (bib45) 2012; 134 Shen, Pouliot, Hall, Gottesman (bib3) 2012; 64 Chow, Licona, Yuan Qiang Wong, Pastorin, Gaiddon, Ang (bib57) 2014; 57 Haghdoost, Guard, Golbaghi, Castonguay (bib68) 2018; 57 Wang (10.1016/j.ejmech.2018.08.054_bib55) 2014; 131 Liu (10.1016/j.ejmech.2018.08.054_bib19) 2010; 41 García-Berrocal (10.1016/j.ejmech.2018.08.054_bib21) 2007; 152 Dougan (10.1016/j.ejmech.2018.08.054_bib58) 2008; 105 Rosenberg (10.1016/j.ejmech.2018.08.054_bib13) 1967; 242 Mendoza-Ferri (10.1016/j.ejmech.2018.08.054_bib66) 2009; 52 Lippert (10.1016/j.ejmech.2018.08.054_bib12) 1999 Miller (10.1016/j.ejmech.2018.08.054_bib14) 2010; 2 Wheate (10.1016/j.ejmech.2018.08.054_bib4) 2010; 39 Jia (10.1016/j.ejmech.2018.08.054_bib61) 2016; 66 Pan (10.1016/j.ejmech.2018.08.054_bib1) 2016; 43 Yang (10.1016/j.ejmech.2018.08.054_bib28) 2012; 94 Sheldrick (10.1016/j.ejmech.2018.08.054_bib70) 2008; 64 Frei (10.1016/j.ejmech.2018.08.054_bib46) 2014; 57 Pizarro (10.1016/j.ejmech.2018.08.054_bib51) 2010 Grazul (10.1016/j.ejmech.2018.08.054_bib9) 2009; 253 Rahman (10.1016/j.ejmech.2018.08.054_bib25) 2015; 44 Zhang (10.1016/j.ejmech.2018.08.054_bib52) 2017; 2017 Reedijk (10.1016/j.ejmech.2018.08.054_bib18) 1987; 59 Chen (10.1016/j.ejmech.2018.08.054_bib41) 2015; 58 Cutillas (10.1016/j.ejmech.2018.08.054_bib8) 2013; 257 Herman (10.1016/j.ejmech.2018.08.054_bib49) 2008; 47 Bruijnincx (10.1016/j.ejmech.2018.08.054_bib26) 2008; 12 Soldevila-Barreda (10.1016/j.ejmech.2018.08.054_bib31) 2015; 6 Pitchaimani (10.1016/j.ejmech.2018.08.054_bib65) 2016; 6 Ulukaya (10.1016/j.ejmech.2018.08.054_bib6) 2013; 8 Chanu (10.1016/j.ejmech.2018.08.054_bib35) 2016; 125 Kilpin (10.1016/j.ejmech.2018.08.054_bib42) 2013; 4 Pierroz (10.1016/j.ejmech.2018.08.054_bib45) 2012; 134 Meier (10.1016/j.ejmech.2018.08.054_bib54) 2013; 19 Huang (10.1016/j.ejmech.2018.08.054_bib43) 2014; 57 Adnan Salim Abu-Surrah (10.1016/j.ejmech.2018.08.054_bib5) 2008; 6 Rosenberg (10.1016/j.ejmech.2018.08.054_bib10) 1965; 205 Çalık (10.1016/j.ejmech.2018.08.054_bib62) 2016; 801 Haghdoost (10.1016/j.ejmech.2018.08.054_bib64) 2017; 132 Rahman (10.1016/j.ejmech.2018.08.054_bib71) 2018; 143 Clavel (10.1016/j.ejmech.2018.08.054_bib59) 2015; 58 Fernandez-Gallardo (10.1016/j.ejmech.2018.08.054_bib36) 2015; 6 Sherman (10.1016/j.ejmech.2018.08.054_bib17) 1987; 87 Chow (10.1016/j.ejmech.2018.08.054_bib57) 2014; 57 Acilan (10.1016/j.ejmech.2018.08.054_bib33) 2017; 1861 Cassells (10.1016/j.ejmech.2018.08.054_bib69) 2018; 23 Windsor (10.1016/j.ejmech.2018.08.054_bib23) 2012; 118 Huang (10.1016/j.ejmech.2018.08.054_bib47) 2015; 127 Suss-Fink (10.1016/j.ejmech.2018.08.054_bib40) 2010; 39 Santini (10.1016/j.ejmech.2018.08.054_bib7) 2013; 114 Bergamo (10.1016/j.ejmech.2018.08.054_bib53) 2010; 104 Raveendran (10.1016/j.ejmech.2018.08.054_bib63) 2010; 695 Haghdoost (10.1016/j.ejmech.2018.08.054_bib68) 2018; 57 Rosenberg (10.1016/j.ejmech.2018.08.054_bib11) 1969; 222 Su (10.1016/j.ejmech.2018.08.054_bib56) 2016; 16 Rahman (10.1016/j.ejmech.2018.08.054_bib67) 2015; 44 Singh (10.1016/j.ejmech.2018.08.054_bib27) 2018; 56 Sgambellone (10.1016/j.ejmech.2018.08.054_bib30) 2013; 135 Xu (10.1016/j.ejmech.2018.08.054_bib32) 2011; 14 Galluzzi (10.1016/j.ejmech.2018.08.054_bib2) 2012; 31 Shen (10.1016/j.ejmech.2018.08.054_bib3) 2012; 64 Petit (10.1016/j.ejmech.2018.08.054_bib38) 2004; 25 Lazarevic (10.1016/j.ejmech.2018.08.054_bib37) 2017; 142 Grozav (10.1016/j.ejmech.2018.08.054_bib44) 2015; 58 Padilla (10.1016/j.ejmech.2018.08.054_bib48) 2016; 52 Levi (10.1016/j.ejmech.2018.08.054_bib22) 1981; 282 Potocnjak (10.1016/j.ejmech.2018.08.054_bib15) 2018 Kelland (10.1016/j.ejmech.2018.08.054_bib16) 2007; 7 Zeng (10.1016/j.ejmech.2018.08.054_bib50) 2017; 46 Jadhav (10.1016/j.ejmech.2018.08.054_bib60) 2016; 26 Musumeci (10.1016/j.ejmech.2018.08.054_bib20) 2016; 45 Bhattacharyya (10.1016/j.ejmech.2018.08.054_bib39) 2014; 140 Munteanu (10.1016/j.ejmech.2018.08.054_bib29) 2015; 44 Suntharalingam (10.1016/j.ejmech.2018.08.054_bib34) 2012; 18 Castelán-Martínez (10.1016/j.ejmech.2018.08.054_bib24) 2014; 78 Acilan, C (WOS:000392680200021) 2017; 1861 Dougan, SJ (WOS:000258723800010) 2008; 105 Lazarevic, T (WOS:000418208200003) 2017; 142 Chen, ZF (WOS:000356316600027) 2015; 58 Bergamo, A (WOS:000272417300010) 2010; 104 ROSENBERG, B (WOS:A1969D050300048) 1969; 222 Huang, H. (000447480000103.25) 2015; 127 Kilpin, KJ (WOS:000315597900003) 2013; 4 Frei, A (WOS:000341619400009) 2014; 57 Singh, MP (WOS:000428100800021) 2018; 56 Rahman, FU (WOS:000428216700086) 2018; 143 Petit, A (WOS:000188796600005) 2004; 25 Shen, DW (WOS:000306182000011) 2012; 64 Grozav, A (WOS:000364796100010) 2015; 58 ROSENBERG, B (WOS:A19679137400042) 1967; 242 ROSENBERG, B (WOS:A19656142500056) 1965; 205 Bhattacharyya, S (WOS:000342608900017) 2014; 140 Chow, MJ (WOS:000339540800017) 2014; 57 Zeng, LL (WOS:000412141600005) 2017; 46 Chanu, SB (WOS:000390496600066) 2017; 125 Soldevila-Barreda, JJ (WOS:000353040100001) 2015; 6 Suss-Fink, G (WOS:000274207100001) 2010; 39 Xu, ZM (WOS:000291835600019) 2011; 14 Padilla, R (WOS:000369642800009) 2016; 52 Windsor, RE (WOS:000301647000017) 2012; 118 Rahman, FU (WOS:000355000700017) 2015; 44 Rahman, FU (WOS:000348204700020) 2015; 44 Grazul, M (WOS:000271372100005) 2009; 253 Castelan-Martinez, OD (WOS:000340983500009) 2014; 78 Mendoza-Ferri, MG (WOS:000263530200005) 2009; 52 Zhang, PY (WOS:000397853700003) 2017 Kelland, L (WOS:000248394000011) 2007; 7 Herman, A (WOS:000252019500034) 2008; 47 Jia, WG (WOS:000373415300004) 2016; 66 Su, W (WOS:000380946500003) 2016; 16 Liu, ZG (WOS:000281992800020) 2010; 41 Ulukaya, E (WOS:000318852400066) 2013; 8 Yang, XX (WOS:000300270900009) 2012; 94 Sgambellone, MA (WOS:000322752900060) 2013; 135 Jadhav, GR (WOS:000374988600026) 2016; 26 Cassells, I (WOS:000435951600006) 2018; 23 Abu-Surrah, H. H. A.-S. d. Adnan Salim (000447480000103.1) 2008; 6 Sheldrick, GM (WOS:000251924000011) 2008; 64 Huang, HY (WOS:000344977400020) 2014; 57 Pitchaimani, J (WOS:000385451800116) 2016; 6 Raveendran, R (WOS:000274285200021) 2010; 695 Haghdoost, MM (WOS:000438006700011) 2018; 57 Levi, R.S.A.J.A. (000447480000103.31) 1981; 282 SHERMAN, SE (WOS:A1987K412400014) 1987; 87 Bruijnincx, PCA (WOS:000256076700012) 2008; 12 Wang, ZG (WOS:000329682100007) 2014; 131 Calik, HS (WOS:000366590300017) 2016; 801 Potocnjak, I. (000447480000103.45) 2018 Galluzzi, L (WOS:000302809900001) 2012; 31 Garcia-Berrocal, JR (WOS:000251139600005) 2007; 152 Wheate, NJ (WOS:000281230700001) 2010; 39 Meier, SM (WOS:000325849000030) 2013; 19 Clavel, CM (WOS:000353602200007) 2015; 58 Cutillas, N (WOS:000324450900012) 2013; 257 Lippert, B. (000447480000103.32) 1999 REEDIJK, J (WOS:A1987F757200005) 1987; 59 Musumeci, D (WOS:000376090100031) 2016; 45 Fernandez-Gallardo, J (WOS:000359214100022) 2015; 6 Pierroz, V (WOS:000312430700036) 2012; 134 Haghdoost, M (WOS:000401385100021) 2017; 132 Santini, C (WOS:000329586000018) 2014; 114 Munteanu, CR (WOS:000359089100002) 2015; 44 Suntharalingam, K (WOS:000311111900032) 2012; 18 Pan, ST (WOS:000379956200001) 2016; 43 Pizarro, AM (WOS:000282667000002) 2010; 32 Miller, RP (WOS:000208435700001) 2010; 2 |
| References_xml | – volume: 4 start-page: 1410 year: 2013 end-page: 1419 ident: bib42 article-title: Enzyme inhibition by metal complexes: concepts, strategies and applications publication-title: Chem. Sci. – volume: 127 start-page: 14255 year: 2015 end-page: 14258 ident: bib47 article-title: Highly charged ruthenium(II) polypyridyl complexes as lysosome-localized photosensitizers for two-photon photodynamic therapy publication-title: Angew. Chem. – volume: 132 start-page: 282 year: 2017 end-page: 293 ident: bib64 article-title: Lipophilicity-antiproliferative activity relationship study leads to the preparation of a ruthenium(II) arene complex with considerable in vitro cytotoxicity against cancer cells and a lower in vivo toxicity in zebrafish embryos than clinically approved cis -platin publication-title: Eur. J. Med. Chem. – volume: 58 start-page: 3356 year: 2015 end-page: 3365 ident: bib59 article-title: Modulating the anticancer activity of ruthenium(II)–arene complexes publication-title: J. Med. Chem. – volume: 6 start-page: 5269 year: 2015 end-page: 5283 ident: bib36 article-title: Heterometallic titanium-gold complexes inhibit renal cancer cells in vitro and in vivo publication-title: Chem. Sci. – volume: 26 start-page: 2695 year: 2016 end-page: 2700 ident: bib60 article-title: Synthesis of novel anticancer ruthenium–arene pyridinylmethylene scaffolds via three-component reaction publication-title: Bioorg. Med. Chem. Lett – volume: 43 start-page: 723 year: 2016 end-page: 737 ident: bib1 article-title: Molecular mechanisms for tumour resistance to chemotherapy publication-title: Clin. Exp. Pharmacol. Physiol. – volume: 23 start-page: 763 year: 2018 end-page: 774 ident: bib69 article-title: Impact of various lipophilic substituents on ruthenium(II), rhodium(III) and iridium(III) salicylaldimine-based complexes: synthesis, in vitro cytotoxicity studies and DNA interactions publication-title: J. Biol. Inorg. Chem. – volume: 695 start-page: 630 year: 2010 end-page: 633 ident: bib63 article-title: Ruthenium(II) complexes with 2-(benzylimino-methyl)-4-R-phenol containing the trans(PPh publication-title: J. Organomet. Chem. – volume: 19 start-page: 9297 year: 2013 end-page: 9307 ident: bib54 article-title: Identification of the structural determinants for anticancer activity of a ruthenium arene peptide conjugate publication-title: Chemistry – volume: 222 start-page: 385 year: 1969 end-page: 386 ident: bib11 article-title: Platinum compounds - a new class of potent antitumour agents publication-title: Nature – volume: 801 start-page: 122 year: 2016 end-page: 129 ident: bib62 article-title: Ruthenium (II) complexes of NO ligands: synthesis, characterization and application in transfer hydrogenation of carbonyl compounds publication-title: J. Organomet. Chem. – volume: 64 start-page: 706 year: 2012 end-page: 721 ident: bib3 article-title: Cisplatin resistance: a cellular self-defense mechanism resulting from multiple epigenetic and genetic changes publication-title: Pharmacol. Rev. – volume: 56 start-page: 156 year: 2018 end-page: 167 ident: bib27 article-title: Morin hydrate ameliorates cisplatin-induced ER stress, inflammation and autophagy in HEK-293 cells and mice kidney via PARP-1 regulation publication-title: Int. Immunopharm. – volume: 16 start-page: 787 year: 2016 end-page: 795 ident: bib56 article-title: Development of arene ruthenium antitumor complexes publication-title: Mini rev. Med. Chem. – volume: 114 start-page: 815 year: 2013 end-page: 862 ident: bib7 article-title: Advances in copper complexes as anticancer agents publication-title: Chem. Rev. – volume: 7 start-page: 573 year: 2007 end-page: 584 ident: bib16 article-title: The resurgence of platinum-based cancer chemotherapy publication-title: Nat. Rev. Canc. – volume: 142 start-page: 8 year: 2017 end-page: 31 ident: bib37 article-title: Platinum, palladium, gold and ruthenium complexes as anticancer agents: current clinical uses, cytotoxicity studies and future perspectives publication-title: Eur. J. Med. Chem. – volume: 2017 start-page: 1541 year: 2017 end-page: 1548 ident: bib52 article-title: Redox-active metal complexes for anticancer therapy publication-title: Eur. J. Inorg. Chem. – volume: 257 start-page: 2784 year: 2013 end-page: 2797 ident: bib8 article-title: Anticancer cyclometalated complexes of platinum group metals and gold publication-title: Coord. Chem. Rev. – volume: 12 start-page: 197 year: 2008 end-page: 206 ident: bib26 article-title: New trends for metal complexes with anticancer activity publication-title: Curr. Opin. Chem. Biol. – volume: 57 start-page: 7558 year: 2018 end-page: 7567 ident: bib68 article-title: Anticancer activity and catalytic potential of ruthenium(II)-arene complexes with N,O-donor ligands publication-title: Inorg. Chem. – volume: 134 start-page: 20376 year: 2012 end-page: 20387 ident: bib45 article-title: Molecular and cellular characterization of the biological effects of ruthenium(II) complexes incorporating 2-pyridyl-2-pyrimidine-4-carboxylic acid publication-title: J. Am. Chem. Soc. – volume: 6 start-page: 1 year: 2015 end-page: 9 ident: bib31 article-title: Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design publication-title: Nat. Commun. – volume: 44 start-page: 2166 year: 2015 end-page: 2175 ident: bib67 article-title: Synthesis and anticancer activities of a novel class of mono- and di-metallic Pt(II)(salicylaldiminato)(DMSO or picolino)Cl complexes publication-title: Dalton Trans. – volume: 6 start-page: 90982 year: 2016 end-page: 90992 ident: bib65 article-title: Arene ruthenium(ii) complexes with chalcone, aminoantipyrine and aminopyrimidine based ligands: synthesis, structure and preliminary evaluation of anti-leukemia activity publication-title: RSC Adv. – volume: 131 start-page: 47 year: 2014 end-page: 55 ident: bib55 article-title: Multi-targeted organometallic ruthenium(II)-arene anticancer complexes bearing inhibitors of poly(ADP-ribose) polymerase-1: a strategy to improve cytotoxicity publication-title: J. Inorg. Biochem. – volume: 104 start-page: 79 year: 2010 end-page: 86 ident: bib53 article-title: In vivo tumour and metastasis reduction and in vitro effects on invasion assays of the ruthenium RM175 and osmium AFAP51 organometallics in the mammary cancer model publication-title: J. Inorg. Biochem. – volume: 58 start-page: 4771 year: 2015 end-page: 4789 ident: bib41 article-title: Water-soluble ruthenium(II) complexes with chiral 4-(2,3-dihydroxypropyl)-formamide oxoaporphine (FOA): in vitro and in vivo anticancer activity by stabilization of G-quadruplex DNA, inhibition of telomerase activity, and induction of tumor cell apoptosis publication-title: J. Med. Chem. – volume: 44 start-page: 9872 year: 2015 end-page: 9880 ident: bib25 article-title: Efficient one-pot synthesis of trans-Pt(II)(salicylaldimine)(4-picoline)Cl complexes: effective agents for enhanced expression of p53 tumor suppressor genes publication-title: Dalton Trans. – volume: 52 start-page: 916 year: 2009 end-page: 925 ident: bib66 article-title: Transferring the concept of multinuclearity to ruthenium complexes for improvement of anticancer activity publication-title: J. Med. Chem. – volume: 152 start-page: 1012 year: 2007 end-page: 1020 ident: bib21 article-title: The anticancer drug cisplatin induces an intrinsic apoptotic pathway inside the inner ear publication-title: Br. J. Pharmacol. – volume: 66 start-page: 15 year: 2016 end-page: 18 ident: bib61 article-title: Synthesis, structures and catalytic activities of half-sandwich ruthenium complexes based on Schiff Base ligands publication-title: Inorg. Chem. Commun. – volume: 64 start-page: 112 year: 2008 end-page: 122 ident: bib70 article-title: A short history of SHELX publication-title: Acta Crystallogr. A – volume: 39 start-page: 8113 year: 2010 end-page: 8127 ident: bib4 article-title: The status of platinum anticancer drugs in the clinic and in clinical trials publication-title: Dalton Trans. – volume: 94 start-page: 345 year: 2012 end-page: 353 ident: bib28 article-title: Ruthenium methylimidazole complexes induced apoptosis in lung cancer A549 cells through intrinsic mitochondrial pathway publication-title: Biochimie – volume: 118 start-page: 1856 year: 2012 end-page: 1867 ident: bib23 article-title: Germline genetic polymorphisms may influence chemotherapy response and disease outcome in osteosarcoma publication-title: Cancer – volume: 242 start-page: 1347 year: 1967 end-page: 1352 ident: bib13 article-title: Inhibition of growth or cell division in publication-title: J. Biol. Chem. – volume: 57 start-page: 8971 year: 2014 end-page: 8983 ident: bib43 article-title: Targeting nucleus DNA with a cyclometalated dipyridophenazineruthenium(II) complex publication-title: J. Med. Chem. – volume: 18 start-page: 15133 year: 2012 end-page: 15141 ident: bib34 article-title: A tri-copper(II) complex displaying DNA-cleaving properties and antiproliferative activity against cancer cells publication-title: Chemistry – volume: 25 start-page: 2013 year: 2004 end-page: 2018 ident: bib38 article-title: Effect of cobalt and chromium ions on bcl-2, bax, caspase-3, and caspase-8 expression in human U937 macrophages publication-title: Biomaterials – volume: 140 start-page: 131 year: 2014 end-page: 142 ident: bib39 article-title: Effect of glucosamine conjugation to zinc(II) complexes of a bis-pyrazole ligand: syntheses, characterization and anticancer activity publication-title: J. Inorg. Biochem. – start-page: 21 year: 2010 end-page: 56 ident: bib51 article-title: Activation mechanisms for organometallic anticancer complexes publication-title: Medicinal Organometallic Chemistry – volume: 1861 start-page: 218 year: 2017 end-page: 234 ident: bib33 article-title: Synthesis, biological characterization and evaluation of molecular mechanisms of novel copper complexes as anticancer agents publication-title: Biochim. Biophys. Acta – volume: 47 start-page: 274 year: 2008 end-page: 280 ident: bib49 article-title: Synthesis, characterization, and in vitro evaluation of a potentially selective anticancer, mixed-metal [ruthenium(III)-platinum(II)] trinuclear complex publication-title: Inorg. Chem. – volume: 39 start-page: 1673 year: 2010 end-page: 1688 ident: bib40 article-title: Arene ruthenium complexes as anticancer agents publication-title: Dalton Trans. – volume: 135 start-page: 11274 year: 2013 end-page: 11282 ident: bib30 article-title: Cellular toxicity induced by the photorelease of a caged bioactive molecule: design of a potential dual-action Ru(II) complex publication-title: J. Am. Chem. Soc. – volume: 14 start-page: 882 year: 2011 end-page: 883 ident: bib32 article-title: Photoinduced DNA binding of a multi-metallic (Cu(II)/Ru(II)/Pt(II)) porphyrin complex publication-title: Inorg. Chem. Commun. – volume: 31 start-page: 1869 year: 2012 end-page: 1883 ident: bib2 article-title: Molecular mechanisms of cisplatin resistance publication-title: Oncogene – start-page: 1 year: 2018 end-page: 8 ident: bib15 article-title: Carvacrol induces cytotoxicity in human cervical cancer cells but causes cisplatin resistance: involvement of MEK-ERK activation publication-title: Phytother Res. – volume: 57 start-page: 7280 year: 2014 end-page: 7292 ident: bib46 article-title: Synthesis, characterization, and biological evaluation of new Ru(II) polypyridyl photosensitizers for photodynamic therapy publication-title: J. Med. Chem. – volume: 105 start-page: 11628 year: 2008 end-page: 11633 ident: bib58 article-title: Catalytic organometallic anticancer complexes publication-title: Proc. Natl. Acad. Sci. U.S.A. – volume: 125 start-page: 816 year: 2016 end-page: 824 ident: bib35 article-title: Potent anticancer activity of photo-activated oxo-bridged diiron(III) complexes publication-title: Eur. J. Med. Chem. – volume: 143 start-page: 1039 year: 2018 end-page: 1052 ident: bib71 article-title: Homo- and heteroleptic Pt(II) complexes of ONN donor hydrazone and 4-picoline: a synthetic, structural and detailed mechanistic anticancer investigation publication-title: Eur. J. Med. Chem. – volume: 46 start-page: 5771 year: 2017 end-page: 5804 ident: bib50 article-title: The development of anticancer ruthenium(ii) complexes: from single molecule compounds to nanomaterials publication-title: Chem. Soc. Rev. – volume: 59 start-page: 181 year: 1987 end-page: 192 ident: bib18 article-title: The mechanism of action of platinum anti-tumor drugs publication-title: Pure Appl. Chem. – volume: 2 start-page: 2490 year: 2010 end-page: 2518 ident: bib14 article-title: Mechanisms of cisplatin nephrotoxicity publication-title: Toxins – volume: 41 start-page: 833 year: 2010 end-page: 839 ident: bib19 article-title: The interactions of cisplatin and DNA studied by atomic force microscopy publication-title: Micron – volume: 78 start-page: 1456 year: 2014 end-page: 1460 ident: bib24 article-title: Hearing loss in Mexican children treated with cisplatin publication-title: Int. J. Pediatr. Otorhinolaryngol. – volume: 282 year: 1981 ident: bib22 article-title: Haemolytic anemia after cisplatin publication-title: Br. Med. J. – year: 1999 ident: bib12 article-title: Cisplatin: Chemistry and Biochemistry of a Leading Anticancer Drug – volume: 52 start-page: 2705 year: 2016 end-page: 2708 ident: bib48 article-title: A new class of Ru(II) polyazine agents with potential for photodynamic therapy publication-title: Chem. Commun. (J. Chem. Soc. Sect. D) – volume: 8 year: 2013 ident: bib6 article-title: Differential cytotoxic activity of a novel palladium-based compound on prostate cell lines, primary prostate epithelial cells and prostate stem cells publication-title: PLoS One – volume: 205 start-page: 698 year: 1965 end-page: 699 ident: bib10 article-title: Inhibition of cell division in Escherichia Coli by electrolysis products from a platinum electrode publication-title: Nature – volume: 58 start-page: 8475 year: 2015 end-page: 8490 ident: bib44 article-title: Synthesis, anticancer activity, and genome profiling of thiazolo arene ruthenium complexes publication-title: J. Med. Chem. – volume: 44 start-page: 13796 year: 2015 end-page: 13808 ident: bib29 article-title: Advances in cobalt complexes as anticancer agents publication-title: Dalton Trans. – volume: 253 start-page: 2588 year: 2009 end-page: 2598 ident: bib9 article-title: Biological activity of metal ions complexes of chromones, coumarins and flavones publication-title: Coord. Chem. Rev. – volume: 45 start-page: 8587 year: 2016 end-page: 8600 ident: bib20 article-title: A first-in-class and a fished out anticancer platinum compound: cis-[PtCl publication-title: Dalton Trans. – volume: 57 start-page: 6043 year: 2014 end-page: 6059 ident: bib57 article-title: Discovery and investigation of anticancer ruthenium-arene Schiff-base complexes via water-promoted combinatorial three-component assembly publication-title: J. Med. Chem. – volume: 87 start-page: 1153 year: 1987 end-page: 1181 ident: bib17 article-title: Structural aspects of platinum anticancer drug interactions with DNA publication-title: Chem. Rev. – volume: 6 start-page: 1 year: 2008 end-page: 10 ident: bib5 article-title: Palladium-based chemotherapeutic agents: routes toward complexes with good antitumor activity publication-title: Canc. Ther. – volume: 2017 start-page: 1541 year: 2017 ident: 10.1016/j.ejmech.2018.08.054_bib52 article-title: Redox-active metal complexes for anticancer therapy publication-title: Eur. J. Inorg. Chem. doi: 10.1002/ejic.201600908 – start-page: 21 year: 2010 ident: 10.1016/j.ejmech.2018.08.054_bib51 article-title: Activation mechanisms for organometallic anticancer complexes – volume: 8 year: 2013 ident: 10.1016/j.ejmech.2018.08.054_bib6 article-title: Differential cytotoxic activity of a novel palladium-based compound on prostate cell lines, primary prostate epithelial cells and prostate stem cells publication-title: PLoS One doi: 10.1371/journal.pone.0064278 – volume: 14 start-page: 882 year: 2011 ident: 10.1016/j.ejmech.2018.08.054_bib32 article-title: Photoinduced DNA binding of a multi-metallic (Cu(II)/Ru(II)/Pt(II)) porphyrin complex publication-title: Inorg. Chem. Commun. doi: 10.1016/j.inoche.2011.03.017 – volume: 25 start-page: 2013 year: 2004 ident: 10.1016/j.ejmech.2018.08.054_bib38 article-title: Effect of cobalt and chromium ions on bcl-2, bax, caspase-3, and caspase-8 expression in human U937 macrophages publication-title: Biomaterials doi: 10.1016/j.biomaterials.2003.08.040 – volume: 242 start-page: 1347 year: 1967 ident: 10.1016/j.ejmech.2018.08.054_bib13 article-title: Inhibition of growth or cell division in Escherichia Coli by different ionic species of platinu(IV) complexes publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)96186-7 – volume: 6 start-page: 1 year: 2015 ident: 10.1016/j.ejmech.2018.08.054_bib31 article-title: Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design publication-title: Nat. Commun. doi: 10.1038/ncomms7582 – volume: 105 start-page: 11628 year: 2008 ident: 10.1016/j.ejmech.2018.08.054_bib58 article-title: Catalytic organometallic anticancer complexes publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.0800076105 – volume: 6 start-page: 5269 year: 2015 ident: 10.1016/j.ejmech.2018.08.054_bib36 article-title: Heterometallic titanium-gold complexes inhibit renal cancer cells in vitro and in vivo publication-title: Chem. Sci. doi: 10.1039/C5SC01753J – volume: 58 start-page: 4771 year: 2015 ident: 10.1016/j.ejmech.2018.08.054_bib41 article-title: Water-soluble ruthenium(II) complexes with chiral 4-(2,3-dihydroxypropyl)-formamide oxoaporphine (FOA): in vitro and in vivo anticancer activity by stabilization of G-quadruplex DNA, inhibition of telomerase activity, and induction of tumor cell apoptosis publication-title: J. Med. Chem. doi: 10.1021/acs.jmedchem.5b00444 – volume: 152 start-page: 1012 year: 2007 ident: 10.1016/j.ejmech.2018.08.054_bib21 article-title: The anticancer drug cisplatin induces an intrinsic apoptotic pathway inside the inner ear publication-title: Br. J. Pharmacol. doi: 10.1038/sj.bjp.0707405 – volume: 695 start-page: 630 year: 2010 ident: 10.1016/j.ejmech.2018.08.054_bib63 article-title: Ruthenium(II) complexes with 2-(benzylimino-methyl)-4-R-phenol containing the trans(PPh3), cis(CO, Cl)-{Ru(PPh3)2(CO)Cl}+ unit publication-title: J. Organomet. Chem. doi: 10.1016/j.jorganchem.2009.11.020 – volume: 39 start-page: 8113 year: 2010 ident: 10.1016/j.ejmech.2018.08.054_bib4 article-title: The status of platinum anticancer drugs in the clinic and in clinical trials publication-title: Dalton Trans. doi: 10.1039/c0dt00292e – volume: 52 start-page: 2705 year: 2016 ident: 10.1016/j.ejmech.2018.08.054_bib48 article-title: A new class of Ru(II) polyazine agents with potential for photodynamic therapy publication-title: Chem. Commun. (J. Chem. Soc. Sect. D) doi: 10.1039/C5CC08682E – volume: 31 start-page: 1869 year: 2012 ident: 10.1016/j.ejmech.2018.08.054_bib2 article-title: Molecular mechanisms of cisplatin resistance publication-title: Oncogene doi: 10.1038/onc.2011.384 – volume: 66 start-page: 15 year: 2016 ident: 10.1016/j.ejmech.2018.08.054_bib61 article-title: Synthesis, structures and catalytic activities of half-sandwich ruthenium complexes based on Schiff Base ligands publication-title: Inorg. Chem. Commun. doi: 10.1016/j.inoche.2016.02.001 – volume: 57 start-page: 6043 year: 2014 ident: 10.1016/j.ejmech.2018.08.054_bib57 article-title: Discovery and investigation of anticancer ruthenium-arene Schiff-base complexes via water-promoted combinatorial three-component assembly publication-title: J. Med. Chem. doi: 10.1021/jm500455p – volume: 142 start-page: 8 year: 2017 ident: 10.1016/j.ejmech.2018.08.054_bib37 article-title: Platinum, palladium, gold and ruthenium complexes as anticancer agents: current clinical uses, cytotoxicity studies and future perspectives publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2017.04.007 – start-page: 1 year: 2018 ident: 10.1016/j.ejmech.2018.08.054_bib15 article-title: Carvacrol induces cytotoxicity in human cervical cancer cells but causes cisplatin resistance: involvement of MEK-ERK activation publication-title: Phytother Res. – volume: 47 start-page: 274 year: 2008 ident: 10.1016/j.ejmech.2018.08.054_bib49 article-title: Synthesis, characterization, and in vitro evaluation of a potentially selective anticancer, mixed-metal [ruthenium(III)-platinum(II)] trinuclear complex publication-title: Inorg. Chem. doi: 10.1021/ic062419h – volume: 104 start-page: 79 year: 2010 ident: 10.1016/j.ejmech.2018.08.054_bib53 article-title: In vivo tumour and metastasis reduction and in vitro effects on invasion assays of the ruthenium RM175 and osmium AFAP51 organometallics in the mammary cancer model publication-title: J. Inorg. Biochem. doi: 10.1016/j.jinorgbio.2009.10.005 – volume: 57 start-page: 7558 year: 2018 ident: 10.1016/j.ejmech.2018.08.054_bib68 article-title: Anticancer activity and catalytic potential of ruthenium(II)-arene complexes with N,O-donor ligands publication-title: Inorg. Chem. doi: 10.1021/acs.inorgchem.8b00346 – volume: 205 start-page: 698 year: 1965 ident: 10.1016/j.ejmech.2018.08.054_bib10 article-title: Inhibition of cell division in Escherichia Coli by electrolysis products from a platinum electrode publication-title: Nature doi: 10.1038/205698a0 – volume: 45 start-page: 8587 year: 2016 ident: 10.1016/j.ejmech.2018.08.054_bib20 article-title: A first-in-class and a fished out anticancer platinum compound: cis-[PtCl2(NH3)2] and cis-[PtI2(NH3)2] compared for their reactivity towards DNA model systems publication-title: Dalton Trans. doi: 10.1039/C6DT00294C – volume: 114 start-page: 815 year: 2013 ident: 10.1016/j.ejmech.2018.08.054_bib7 article-title: Advances in copper complexes as anticancer agents publication-title: Chem. Rev. doi: 10.1021/cr400135x – volume: 118 start-page: 1856 year: 2012 ident: 10.1016/j.ejmech.2018.08.054_bib23 article-title: Germline genetic polymorphisms may influence chemotherapy response and disease outcome in osteosarcoma publication-title: Cancer doi: 10.1002/cncr.26472 – volume: 44 start-page: 13796 year: 2015 ident: 10.1016/j.ejmech.2018.08.054_bib29 article-title: Advances in cobalt complexes as anticancer agents publication-title: Dalton Trans. doi: 10.1039/C5DT02101D – volume: 57 start-page: 8971 year: 2014 ident: 10.1016/j.ejmech.2018.08.054_bib43 article-title: Targeting nucleus DNA with a cyclometalated dipyridophenazineruthenium(II) complex publication-title: J. Med. Chem. doi: 10.1021/jm501095r – volume: 64 start-page: 706 year: 2012 ident: 10.1016/j.ejmech.2018.08.054_bib3 article-title: Cisplatin resistance: a cellular self-defense mechanism resulting from multiple epigenetic and genetic changes publication-title: Pharmacol. Rev. doi: 10.1124/pr.111.005637 – volume: 26 start-page: 2695 year: 2016 ident: 10.1016/j.ejmech.2018.08.054_bib60 article-title: Synthesis of novel anticancer ruthenium–arene pyridinylmethylene scaffolds via three-component reaction publication-title: Bioorg. Med. Chem. Lett doi: 10.1016/j.bmcl.2016.04.005 – volume: 143 start-page: 1039 year: 2018 ident: 10.1016/j.ejmech.2018.08.054_bib71 article-title: Homo- and heteroleptic Pt(II) complexes of ONN donor hydrazone and 4-picoline: a synthetic, structural and detailed mechanistic anticancer investigation publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2017.11.044 – volume: 87 start-page: 1153 year: 1987 ident: 10.1016/j.ejmech.2018.08.054_bib17 article-title: Structural aspects of platinum anticancer drug interactions with DNA publication-title: Chem. Rev. doi: 10.1021/cr00081a013 – volume: 43 start-page: 723 year: 2016 ident: 10.1016/j.ejmech.2018.08.054_bib1 article-title: Molecular mechanisms for tumour resistance to chemotherapy publication-title: Clin. Exp. Pharmacol. Physiol. doi: 10.1111/1440-1681.12581 – volume: 131 start-page: 47 year: 2014 ident: 10.1016/j.ejmech.2018.08.054_bib55 article-title: Multi-targeted organometallic ruthenium(II)-arene anticancer complexes bearing inhibitors of poly(ADP-ribose) polymerase-1: a strategy to improve cytotoxicity publication-title: J. Inorg. Biochem. doi: 10.1016/j.jinorgbio.2013.10.017 – volume: 78 start-page: 1456 year: 2014 ident: 10.1016/j.ejmech.2018.08.054_bib24 article-title: Hearing loss in Mexican children treated with cisplatin publication-title: Int. J. Pediatr. Otorhinolaryngol. doi: 10.1016/j.ijporl.2014.06.007 – volume: 18 start-page: 15133 year: 2012 ident: 10.1016/j.ejmech.2018.08.054_bib34 article-title: A tri-copper(II) complex displaying DNA-cleaving properties and antiproliferative activity against cancer cells publication-title: Chemistry doi: 10.1002/chem.201202482 – volume: 39 start-page: 1673 year: 2010 ident: 10.1016/j.ejmech.2018.08.054_bib40 article-title: Arene ruthenium complexes as anticancer agents publication-title: Dalton Trans. doi: 10.1039/B916860P – volume: 44 start-page: 2166 year: 2015 ident: 10.1016/j.ejmech.2018.08.054_bib67 article-title: Synthesis and anticancer activities of a novel class of mono- and di-metallic Pt(II)(salicylaldiminato)(DMSO or picolino)Cl complexes publication-title: Dalton Trans. doi: 10.1039/C4DT03018D – volume: 12 start-page: 197 year: 2008 ident: 10.1016/j.ejmech.2018.08.054_bib26 article-title: New trends for metal complexes with anticancer activity publication-title: Curr. Opin. Chem. Biol. doi: 10.1016/j.cbpa.2007.11.013 – volume: 134 start-page: 20376 year: 2012 ident: 10.1016/j.ejmech.2018.08.054_bib45 article-title: Molecular and cellular characterization of the biological effects of ruthenium(II) complexes incorporating 2-pyridyl-2-pyrimidine-4-carboxylic acid publication-title: J. Am. Chem. Soc. doi: 10.1021/ja307288s – volume: 57 start-page: 7280 year: 2014 ident: 10.1016/j.ejmech.2018.08.054_bib46 article-title: Synthesis, characterization, and biological evaluation of new Ru(II) polypyridyl photosensitizers for photodynamic therapy publication-title: J. Med. Chem. doi: 10.1021/jm500566f – volume: 257 start-page: 2784 year: 2013 ident: 10.1016/j.ejmech.2018.08.054_bib8 article-title: Anticancer cyclometalated complexes of platinum group metals and gold publication-title: Coord. Chem. Rev. doi: 10.1016/j.ccr.2013.03.024 – volume: 46 start-page: 5771 year: 2017 ident: 10.1016/j.ejmech.2018.08.054_bib50 article-title: The development of anticancer ruthenium(ii) complexes: from single molecule compounds to nanomaterials publication-title: Chem. Soc. Rev. doi: 10.1039/C7CS00195A – volume: 23 start-page: 763 year: 2018 ident: 10.1016/j.ejmech.2018.08.054_bib69 article-title: Impact of various lipophilic substituents on ruthenium(II), rhodium(III) and iridium(III) salicylaldimine-based complexes: synthesis, in vitro cytotoxicity studies and DNA interactions publication-title: J. Biol. Inorg. Chem. doi: 10.1007/s00775-018-1567-3 – volume: 801 start-page: 122 year: 2016 ident: 10.1016/j.ejmech.2018.08.054_bib62 article-title: Ruthenium (II) complexes of NO ligands: synthesis, characterization and application in transfer hydrogenation of carbonyl compounds publication-title: J. Organomet. Chem. doi: 10.1016/j.jorganchem.2015.10.028 – volume: 52 start-page: 916 year: 2009 ident: 10.1016/j.ejmech.2018.08.054_bib66 article-title: Transferring the concept of multinuclearity to ruthenium complexes for improvement of anticancer activity publication-title: J. Med. Chem. doi: 10.1021/jm8013234 – volume: 253 start-page: 2588 year: 2009 ident: 10.1016/j.ejmech.2018.08.054_bib9 article-title: Biological activity of metal ions complexes of chromones, coumarins and flavones publication-title: Coord. Chem. Rev. doi: 10.1016/j.ccr.2009.06.015 – year: 1999 ident: 10.1016/j.ejmech.2018.08.054_bib12 – volume: 282 year: 1981 ident: 10.1016/j.ejmech.2018.08.054_bib22 article-title: Haemolytic anemia after cisplatin publication-title: Br. Med. J. doi: 10.1136/bmj.282.6281.2003 – volume: 2 start-page: 2490 year: 2010 ident: 10.1016/j.ejmech.2018.08.054_bib14 article-title: Mechanisms of cisplatin nephrotoxicity publication-title: Toxins doi: 10.3390/toxins2112490 – volume: 125 start-page: 816 year: 2016 ident: 10.1016/j.ejmech.2018.08.054_bib35 article-title: Potent anticancer activity of photo-activated oxo-bridged diiron(III) complexes publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2016.09.090 – volume: 132 start-page: 282 year: 2017 ident: 10.1016/j.ejmech.2018.08.054_bib64 publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2017.03.029 – volume: 94 start-page: 345 year: 2012 ident: 10.1016/j.ejmech.2018.08.054_bib28 article-title: Ruthenium methylimidazole complexes induced apoptosis in lung cancer A549 cells through intrinsic mitochondrial pathway publication-title: Biochimie doi: 10.1016/j.biochi.2011.07.025 – volume: 135 start-page: 11274 year: 2013 ident: 10.1016/j.ejmech.2018.08.054_bib30 article-title: Cellular toxicity induced by the photorelease of a caged bioactive molecule: design of a potential dual-action Ru(II) complex publication-title: J. Am. Chem. Soc. doi: 10.1021/ja4045604 – volume: 6 start-page: 90982 year: 2016 ident: 10.1016/j.ejmech.2018.08.054_bib65 article-title: Arene ruthenium(ii) complexes with chalcone, aminoantipyrine and aminopyrimidine based ligands: synthesis, structure and preliminary evaluation of anti-leukemia activity publication-title: RSC Adv. doi: 10.1039/C6RA18504E – volume: 6 start-page: 1 year: 2008 ident: 10.1016/j.ejmech.2018.08.054_bib5 article-title: Palladium-based chemotherapeutic agents: routes toward complexes with good antitumor activity publication-title: Canc. Ther. – volume: 44 start-page: 9872 year: 2015 ident: 10.1016/j.ejmech.2018.08.054_bib25 article-title: Efficient one-pot synthesis of trans-Pt(II)(salicylaldimine)(4-picoline)Cl complexes: effective agents for enhanced expression of p53 tumor suppressor genes publication-title: Dalton Trans. doi: 10.1039/C5DT01098E – volume: 1861 start-page: 218 year: 2017 ident: 10.1016/j.ejmech.2018.08.054_bib33 article-title: Synthesis, biological characterization and evaluation of molecular mechanisms of novel copper complexes as anticancer agents publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbagen.2016.10.014 – volume: 127 start-page: 14255 year: 2015 ident: 10.1016/j.ejmech.2018.08.054_bib47 article-title: Highly charged ruthenium(II) polypyridyl complexes as lysosome-localized photosensitizers for two-photon photodynamic therapy publication-title: Angew. Chem. doi: 10.1002/ange.201507800 – volume: 7 start-page: 573 year: 2007 ident: 10.1016/j.ejmech.2018.08.054_bib16 article-title: The resurgence of platinum-based cancer chemotherapy publication-title: Nat. Rev. Canc. doi: 10.1038/nrc2167 – volume: 64 start-page: 112 year: 2008 ident: 10.1016/j.ejmech.2018.08.054_bib70 article-title: A short history of SHELX publication-title: Acta Crystallogr. A doi: 10.1107/S0108767307043930 – volume: 41 start-page: 833 year: 2010 ident: 10.1016/j.ejmech.2018.08.054_bib19 article-title: The interactions of cisplatin and DNA studied by atomic force microscopy publication-title: Micron doi: 10.1016/j.micron.2010.05.001 – volume: 140 start-page: 131 year: 2014 ident: 10.1016/j.ejmech.2018.08.054_bib39 article-title: Effect of glucosamine conjugation to zinc(II) complexes of a bis-pyrazole ligand: syntheses, characterization and anticancer activity publication-title: J. Inorg. Biochem. doi: 10.1016/j.jinorgbio.2014.07.009 – volume: 19 start-page: 9297 year: 2013 ident: 10.1016/j.ejmech.2018.08.054_bib54 article-title: Identification of the structural determinants for anticancer activity of a ruthenium arene peptide conjugate publication-title: Chemistry doi: 10.1002/chem.201300889 – volume: 4 start-page: 1410 year: 2013 ident: 10.1016/j.ejmech.2018.08.054_bib42 article-title: Enzyme inhibition by metal complexes: concepts, strategies and applications publication-title: Chem. Sci. doi: 10.1039/c3sc22349c – volume: 58 start-page: 8475 year: 2015 ident: 10.1016/j.ejmech.2018.08.054_bib44 article-title: Synthesis, anticancer activity, and genome profiling of thiazolo arene ruthenium complexes publication-title: J. Med. Chem. doi: 10.1021/acs.jmedchem.5b00855 – volume: 16 start-page: 787 year: 2016 ident: 10.1016/j.ejmech.2018.08.054_bib56 article-title: Development of arene ruthenium antitumor complexes publication-title: Mini rev. Med. Chem. doi: 10.2174/138955751610160503003937 – volume: 56 start-page: 156 year: 2018 ident: 10.1016/j.ejmech.2018.08.054_bib27 article-title: Morin hydrate ameliorates cisplatin-induced ER stress, inflammation and autophagy in HEK-293 cells and mice kidney via PARP-1 regulation publication-title: Int. Immunopharm. doi: 10.1016/j.intimp.2018.01.031 – volume: 59 start-page: 181 year: 1987 ident: 10.1016/j.ejmech.2018.08.054_bib18 article-title: The mechanism of action of platinum anti-tumor drugs publication-title: Pure Appl. Chem. doi: 10.1351/pac198759020181 – volume: 58 start-page: 3356 year: 2015 ident: 10.1016/j.ejmech.2018.08.054_bib59 article-title: Modulating the anticancer activity of ruthenium(II)–arene complexes publication-title: J. Med. Chem. doi: 10.1021/jm501655t – volume: 222 start-page: 385 year: 1969 ident: 10.1016/j.ejmech.2018.08.054_bib11 article-title: Platinum compounds - a new class of potent antitumour agents publication-title: Nature doi: 10.1038/222385a0 – volume: 132 start-page: 282 year: 2017 ident: WOS:000401385100021 article-title: Lipophilicity-antiproliferative activity relationship study leads to the preparation of a ruthenium(II) arene complex with considerable in vitro cytotoxicity against cancer cells and a lower in vivo toxicity in zebrafish embryos than clinically approved cis-platin publication-title: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY doi: 10.1016/j.ejmech.2017.03.029 – volume: 143 start-page: 1039 year: 2018 ident: WOS:000428216700086 article-title: Homo- and heteroleptic Pt(II) complexes of ONN donor hydrazone and 4-picoline: A synthetic, structural and detailed mechanistic anticancer investigation publication-title: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY doi: 10.1016/j.ejmech.2017.11.044 – volume: 801 start-page: 122 year: 2016 ident: WOS:000366590300017 article-title: Ruthenium (II) complexes of NO ligands: Synthesis, characterization and application in transfer hydrogenation of carbonyl compounds publication-title: JOURNAL OF ORGANOMETALLIC CHEMISTRY doi: 10.1016/j.jorganchem.2015.10.028 – volume: 87 start-page: 1153 year: 1987 ident: WOS:A1987K412400014 article-title: STRUCTURAL ASPECTS OF PLATINUM ANTICANCER DRUG-INTERACTIONS WITH DNA publication-title: CHEMICAL REVIEWS – volume: 2 start-page: 2490 year: 2010 ident: WOS:000208435700001 article-title: Mechanisms of Cisplatin Nephrotoxicity publication-title: TOXINS doi: 10.3390/toxins2112490 – year: 1999 ident: 000447480000103.32 article-title: Cisplatin: Chemistry and Biochemistry of a Leading Anticancer Drug publication-title: Verlag Helvetica Chimica Acta Zurich – volume: 57 start-page: 7280 year: 2014 ident: WOS:000341619400009 article-title: Synthesis, Characterization, and Biological Evaluation of New Ru(II) Polypyridyl Photosensitizers for Photodynamic Therapy publication-title: JOURNAL OF MEDICINAL CHEMISTRY doi: 10.1021/jm500566f – volume: 134 start-page: 20376 year: 2012 ident: WOS:000312430700036 article-title: Molecular and Cellular Characterization of the Biological Effects of Ruthenium(II) Complexes Incorporating 2-Pyridyl-2-pyrimidine-4-carboxylic Acid publication-title: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY doi: 10.1021/ja307288s – volume: 59 start-page: 181 year: 1987 ident: WOS:A1987F757200005 article-title: THE MECHANISM OF ACTION OF PLATINUM ANTITUMOR DRUGS publication-title: PURE AND APPLIED CHEMISTRY – volume: 205 start-page: 698 year: 1965 ident: WOS:A19656142500056 article-title: INHIBITION OF CELL DIVISION IN ESCHERICHIA COLI BY ELECTROLYSIS PRODUCTS FROM A PLATINUM ELECTRODE publication-title: NATURE – volume: 118 start-page: 1856 year: 2012 ident: WOS:000301647000017 article-title: Germline Genetic Polymorphisms May Influence Chemotherapy Response and Disease Outcome in Osteosarcoma publication-title: CANCER doi: 10.1002/cncr.26472 – volume: 131 start-page: 47 year: 2014 ident: WOS:000329682100007 article-title: Multi-targeted organometallic ruthenium(II)-arene anticancer complexes bearing inhibitors of poly(ADP-ribose) polymerase-1: A strategy to improve cytotoxicity publication-title: JOURNAL OF INORGANIC BIOCHEMISTRY doi: 10.1016/j.jinorgbio.2013.10.017 – volume: 6 start-page: 5269 year: 2015 ident: WOS:000359214100022 article-title: Heterometallic titanium-gold complexes inhibit renal cancer cells in vitro and in vivo publication-title: CHEMICAL SCIENCE doi: 10.1039/c5sc01753j – start-page: 1541 year: 2017 ident: WOS:000397853700003 article-title: Redox-Active Metal Complexes for Anticancer Therapy publication-title: EUROPEAN JOURNAL OF INORGANIC CHEMISTRY doi: 10.1002/ejic.201600908 – volume: 104 start-page: 79 year: 2010 ident: WOS:000272417300010 article-title: In vivo tumour and metastasis reduction and in vitro effects on invasion assays of the ruthenium RM175 and osmium AFAP51 organometallics in the mammary cancer model publication-title: JOURNAL OF INORGANIC BIOCHEMISTRY doi: 10.1016/j.jinorgbio.2009.10.005 – volume: 39 start-page: 1673 year: 2010 ident: WOS:000274207100001 article-title: Arene ruthenium complexes as anticancer agents publication-title: DALTON TRANSACTIONS doi: 10.1039/b916860p – volume: 19 start-page: 9297 year: 2013 ident: WOS:000325849000030 article-title: Identification of the Structural Determinants for Anticancer Activity of a Ruthenium Arene Peptide Conjugate publication-title: CHEMISTRY-A EUROPEAN JOURNAL doi: 10.1002/chem.201300889 – volume: 1861 start-page: 218 year: 2017 ident: WOS:000392680200021 article-title: Synthesis, biological characterization and evaluation of molecular mechanisms of novel copper complexes as anticancer agents publication-title: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS doi: 10.1016/j.bbagen.2016.10.014 – volume: 94 start-page: 345 year: 2012 ident: WOS:000300270900009 article-title: Ruthenium methylimidazole complexes induced apoptosis in lung cancer A549 cells through intrinsic mitochondrial pathway publication-title: BIOCHIMIE doi: 10.1016/j.biochi.2011.07.025 – volume: 105 start-page: 11628 year: 2008 ident: WOS:000258723800010 article-title: Catalytic organometallic anticancer complexes publication-title: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA doi: 10.1073/pnas.0800076105 – volume: 58 start-page: 4771 year: 2015 ident: WOS:000356316600027 article-title: Water-Soluble Ruthenium(II) Complexes with Chiral 442,3-Dihydroxypropyl)-formamide Oxoaporphine (FOA): In Vitro and in Vivo Anticancer Activity by Stabilization of G-Quadruplex DNA, Inhibition of Telomerase Activity, and Induction of Tumor Cell Apoptosis publication-title: JOURNAL OF MEDICINAL CHEMISTRY doi: 10.1021/acs.jmedchem.5b00444 – volume: 152 start-page: 1012 year: 2007 ident: WOS:000251139600005 article-title: The anticancer drug cisplatin induces an intrinsic apoptotic pathway inside the inner ear publication-title: BRITISH JOURNAL OF PHARMACOLOGY doi: 10.1038/sj.bjp.0707405 – volume: 6 start-page: 90982 year: 2016 ident: WOS:000385451800116 article-title: Arene ruthenium(II) complexes with chalcone, aminoantipyrine and aminopyrimidine based ligands: synthesis, structure and preliminary evaluation of anti-leukemia activity publication-title: RSC ADVANCES doi: 10.1039/c6ra18504e – volume: 41 start-page: 833 year: 2010 ident: WOS:000281992800020 article-title: The interactions of cisplatin and DNA studied by atomic force microscopy publication-title: MICRON doi: 10.1016/j.micron.2010.05.001 – volume: 282 start-page: 2003 year: 1981 ident: 000447480000103.31 article-title: Haemolytic anemia after cisplatin publication-title: Br. Med. J. – volume: 253 start-page: 2588 year: 2009 ident: WOS:000271372100005 article-title: Biological activity of metal ions complexes of chromones, coumarins and flavones publication-title: COORDINATION CHEMISTRY REVIEWS doi: 10.1016/j.ccr.2009.06.015 – volume: 140 start-page: 131 year: 2014 ident: WOS:000342608900017 article-title: Effect of glucosamine conjugation to zinc(II) complexes of a bis-pyrazole ligand: Syntheses, characterization and anticancer activity publication-title: JOURNAL OF INORGANIC BIOCHEMISTRY doi: 10.1016/j.jinorgbio.2014.07.009 – volume: 18 start-page: 15133 year: 2012 ident: WOS:000311111900032 article-title: A Tri-copper(II) Complex Displaying DNA-Cleaving Properties and Antiproliferative Activity against Cancer Cells publication-title: CHEMISTRY-A EUROPEAN JOURNAL doi: 10.1002/chem.201202482 – volume: 6 start-page: 1 year: 2008 ident: 000447480000103.1 article-title: Palladium-based chemotherapeutic agents: routes toward complexes with good antitumor activity publication-title: Canc. Ther. – volume: 64 start-page: 112 year: 2008 ident: WOS:000251924000011 article-title: A short history of SHELX publication-title: ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES doi: 10.1107/S0108767307043930 – volume: 114 start-page: 815 year: 2014 ident: WOS:000329586000018 article-title: Advances in Copper Complexes as Anticancer Agents publication-title: CHEMICAL REVIEWS doi: 10.1021/cr400135x – volume: 47 start-page: 274 year: 2008 ident: WOS:000252019500034 article-title: Synthesis, characterization, and in vitro evaluation of a potentially selective anticancer, mixed-metal [ruthenium(III)-platinum(II)] trinuclear complex publication-title: INORGANIC CHEMISTRY doi: 10.1021/ic062419h – volume: 7 start-page: 573 year: 2007 ident: WOS:000248394000011 article-title: The resurgence of platinum-based cancer chemotherapy publication-title: NATURE REVIEWS CANCER doi: 10.1038/nrc2167 – volume: 12 start-page: 197 year: 2008 ident: WOS:000256076700012 article-title: New trends for metal complexes with anticancer activity publication-title: CURRENT OPINION IN CHEMICAL BIOLOGY doi: 10.1016/j.cbpa.2007.11.013 – volume: 6 start-page: ARTN 6582 year: 2015 ident: WOS:000353040100001 article-title: Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design publication-title: NATURE COMMUNICATIONS doi: 10.1038/ncomms7582 – volume: 64 start-page: 706 year: 2012 ident: WOS:000306182000011 article-title: Cisplatin Resistance: A Cellular Self-Defense Mechanism Resulting from Multiple Epigenetic and Genetic Changes publication-title: PHARMACOLOGICAL REVIEWS doi: 10.1124/pr.111.005637 – volume: 4 start-page: 1410 year: 2013 ident: WOS:000315597900003 article-title: Enzyme inhibition by metal complexes: concepts, strategies and applications publication-title: CHEMICAL SCIENCE doi: 10.1039/c3sc22349c – volume: 222 start-page: 385 year: 1969 ident: WOS:A1969D050300048 article-title: PLATINUM COMPOUNDS - A NEW CLASS OF POTENT ANTITUMOUR AGENTS publication-title: NATURE – volume: 14 start-page: 882 year: 2011 ident: WOS:000291835600019 article-title: Photoinduced DNA binding of a multi-metallic (Cu(II)/Ru(II)/Pt(II)) porphyrin complex publication-title: INORGANIC CHEMISTRY COMMUNICATIONS doi: 10.1016/j.inoche.2011.03.017 – volume: 257 start-page: 2784 year: 2013 ident: WOS:000324450900012 article-title: Anticancer cyclometalated complexes of platinum group metals and gold publication-title: COORDINATION CHEMISTRY REVIEWS doi: 10.1016/j.ccr.2013.03.024 – volume: 52 start-page: 916 year: 2009 ident: WOS:000263530200005 article-title: Transferring the Concept of Multinuclearity to Ruthenium Complexes for Improvement of Anticancer Activity publication-title: JOURNAL OF MEDICINAL CHEMISTRY doi: 10.1021/jm8013234 – volume: 25 start-page: 2013 year: 2004 ident: WOS:000188796600005 article-title: Effect of cobalt and chromium ions on bcl-2, bax, caspase-3, and caspase-8 expression in human U937 macrophages publication-title: BIOMATERIALS doi: 10.1016/j.biomaterials.2003.08.040 – volume: 32 start-page: 21 year: 2010 ident: WOS:000282667000002 article-title: Activation Mechanisms for Organometallic Anticancer Complexes publication-title: MEDICINAL ORGANOMETALLIC CHEMISTRY doi: 10.1007/978-3-642-13185-1_2 – volume: 39 start-page: 8113 year: 2010 ident: WOS:000281230700001 article-title: The status of platinum anticancer drugs in the clinic and in clinical trials publication-title: DALTON TRANSACTIONS doi: 10.1039/c0dt00292e – volume: 44 start-page: 9872 year: 2015 ident: WOS:000355000700017 article-title: Efficient one-pot synthesis of trans-Pt(II)-(salicylaldimine)(4-picoline)Cl complexes: effective agents for enhanced expression of p53 tumor suppressor genes publication-title: DALTON TRANSACTIONS doi: 10.1039/c5dt01098e – volume: 125 start-page: 816 year: 2017 ident: WOS:000390496600066 article-title: Potent anticancer activity of photo-activated oxo-bridged diiron(III) complexes publication-title: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY doi: 10.1016/j.ejmech.2016.09.090 – volume: 66 start-page: 15 year: 2016 ident: WOS:000373415300004 article-title: Synthesis, structures and catalytic activities of half-sandwich ruthenium complexes based on Schiff Base ligands publication-title: INORGANIC CHEMISTRY COMMUNICATIONS doi: 10.1016/j.inoche.2016.02.001 – volume: 57 start-page: 8971 year: 2014 ident: WOS:000344977400020 article-title: Targeting Nucleus DNA with a Cyclometalated Dipyridophenazineruthenium(II) Complex publication-title: JOURNAL OF MEDICINAL CHEMISTRY doi: 10.1021/jm501095r – volume: 31 start-page: 1869 year: 2012 ident: WOS:000302809900001 article-title: Molecular mechanisms of cisplatin resistance publication-title: ONCOGENE doi: 10.1038/onc.2011.384 – volume: 142 start-page: 8 year: 2017 ident: WOS:000418208200003 article-title: Platinum, palladium, gold and ruthenium complexes as anticancer agents: Current clinical uses, cytotoxicity studies and future perspectives publication-title: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY doi: 10.1016/j.ejmech.2017.04.007 – volume: 57 start-page: 7558 year: 2018 ident: WOS:000438006700011 article-title: Anticancer Activity and Catalytic Potential of Ruthenium(11)-Arene Complexes with N,O-Donor Ligands publication-title: INORGANIC CHEMISTRY doi: 10.1021/acs.inorgchem.8b00346 – volume: 78 start-page: 1456 year: 2014 ident: WOS:000340983500009 article-title: Hearing loss in Mexican children treated with cisplatin publication-title: INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY doi: 10.1016/j.ijporl.2014.06.007 – volume: 52 start-page: 2705 year: 2016 ident: WOS:000369642800009 article-title: A new class of Ru(II) polyazine agents with potential for photodynamic therapy publication-title: CHEMICAL COMMUNICATIONS doi: 10.1039/c5cc08682e – start-page: 1 year: 2018 ident: 000447480000103.45 article-title: Carvacrol induces cytotoxicity in human cervical cancer cells but causes cisplatin resistance: involvement of MEK-ERIC activation publication-title: Phytother Res – volume: 26 start-page: 2695 year: 2016 ident: WOS:000374988600026 article-title: Synthesis of novel anticancer ruthenium-arene pyridinylmethylene scaffolds via three-component reaction publication-title: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS doi: 10.1016/j.bmcl.2016.04.005 – volume: 57 start-page: 6043 year: 2014 ident: WOS:000339540800017 article-title: Discovery and Investigation of Anticancer Ruthenium-Arene Schiff-Base Complexes via Water-Promoted Combinatorial Three-Component Assembly publication-title: JOURNAL OF MEDICINAL CHEMISTRY doi: 10.1021/jm500455p – volume: 135 start-page: 11274 year: 2013 ident: WOS:000322752900060 article-title: Cellular Toxicity Induced by the Photorelease of a Caged Bioactive Molecule: Design of a Potential Dual-Action Ru(II) Complex publication-title: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY doi: 10.1021/ja4045604 – volume: 45 start-page: 8587 year: 2016 ident: WOS:000376090100031 article-title: A first-in-class and a fished out anticancer platinum compound: cis-[PtCl2(NH3)(2)] and cis-[PtI2(NH3)(2)] compared for their reactivity towards DNA model systems publication-title: DALTON TRANSACTIONS doi: 10.1039/c6dt00294c – volume: 8 start-page: ARTN e64278 year: 2013 ident: WOS:000318852400066 article-title: Differential Cytotoxic Activity of a Novel Palladium-Based Compound on Prostate Cell Lines, Primary Prostate Epithelial Cells and Prostate Stem Cells publication-title: PLOS ONE doi: 10.1371/journal.pone.0064278 – volume: 56 start-page: 156 year: 2018 ident: WOS:000428100800021 article-title: Morin hydrate ameliorates cisplatin-induced ER stress, inflammation and autophagy in HEK-293 cells and mice kidney via PARP-1 regulation publication-title: INTERNATIONAL IMMUNOPHARMACOLOGY doi: 10.1016/j.intimp.2018.01.031 – volume: 44 start-page: 13796 year: 2015 ident: WOS:000359089100002 article-title: Advances in cobalt complexes as anticancer agents publication-title: DALTON TRANSACTIONS doi: 10.1039/c5dt02101d – volume: 23 start-page: 763 year: 2018 ident: WOS:000435951600006 article-title: Impact of various lipophilic substituents on ruthenium(II), rhodium(III) and iridium(III) salicylaldimine-based complexes: synthesis, in vitro cytotoxicity studies and DNA interactions publication-title: JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY doi: 10.1007/s00775-018-1567-3 – volume: 44 start-page: 2166 year: 2015 ident: WOS:000348204700020 article-title: Synthesis and anticancer activities of a novel class of mono- and di-metallic Pt(II)(salicylaldiminato)-(DMSO or Picolino)Cl complexes publication-title: DALTON TRANSACTIONS doi: 10.1039/c4dt03018d – volume: 242 start-page: 1347 year: 1967 ident: WOS:A19679137400042 article-title: INHIBITION OF GROWTH OR CELL DIVISION IN ESCHERICHIA COLI BY DIFFERENT IONIC SPECIES OF PLATINIUM(4) COMPLEXES publication-title: JOURNAL OF BIOLOGICAL CHEMISTRY – volume: 58 start-page: 8475 year: 2015 ident: WOS:000364796100010 article-title: Synthesis, Anticancer Activity, and Genome Profiling of Thiazolo Arene Ruthenium Complexes publication-title: JOURNAL OF MEDICINAL CHEMISTRY doi: 10.1021/acs.jmedchem.5b00855 – volume: 46 start-page: 5771 year: 2017 ident: WOS:000412141600005 article-title: The development of anticancer ruthenium(II) complexes: from single molecule compounds to nanomaterials publication-title: CHEMICAL SOCIETY REVIEWS doi: 10.1039/c7cs00195a – volume: 127 start-page: 14255 year: 2015 ident: 000447480000103.25 article-title: Highly charged ruthenium(II) polypyridyl complexes as lysosome-localized photosensitizers for two-photon photodynamic therapy publication-title: Angew. Chem. – volume: 58 start-page: 3356 year: 2015 ident: WOS:000353602200007 article-title: Modulating the Anticancer Activity of Ruthenium(II)-Arene Complexes publication-title: JOURNAL OF MEDICINAL CHEMISTRY doi: 10.1021/jm501655t – volume: 695 start-page: 630 year: 2010 ident: WOS:000274285200021 article-title: Ruthenium(II) complexes with 2-(benzylimino-methyl)-4-R-phenol containing the trans(PPh3),cis(CO,Cl)-{Ru(PPh3)(2)(CO)Cl}(+) unit publication-title: JOURNAL OF ORGANOMETALLIC CHEMISTRY doi: 10.1016/j.jorganchem.2009.11.020 – volume: 16 start-page: 787 year: 2016 ident: WOS:000380946500003 article-title: Development of Arene Ruthenium Antitumor Complexes publication-title: MINI-REVIEWS IN MEDICINAL CHEMISTRY doi: 10.2174/138955751610160503003937 – volume: 43 start-page: 723 year: 2016 ident: WOS:000379956200001 article-title: Molecular mechanisms for tumour resistance to chemotherapy publication-title: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY doi: 10.1111/1440-1681.12581 |
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| Snippet | A series of bis-salicylaldimine ligands bearing two ON-donor functions were reacted with dichloro(p-cymene)ruthenium(II) dimer in the presence of base (NaOAc)... |
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| SubjectTerms | Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology bis-Salicylaldimine Cell Death - drug effects Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Chemistry, Medicinal Dimetallic complexes Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Humans Life Sciences & Biomedicine Molecular Structure Neoplasm Invasiveness - pathology Neoplasm Invasiveness - prevention & control Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry Organometallic Compounds - pharmacology Pharmacology & Pharmacy Ru(II) anticancer complexes Ru-(p-cymene) Ru-anticancer complexes Ruthenium - chemistry Ruthenium - pharmacology Science & Technology Signal Transduction - drug effects Structure-Activity Relationship Tumor Suppressor Protein p53 - metabolism |
| Title | Dimetallic Ru(II) arene complexes appended on bis-salicylaldimine induce cancer cell death and suppress invasion via p53-dependent signaling |
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