PSMA-targeted low-molecular double conjugates for diagnostics and therapy

• Published in: European journal of medicinal chemistry Vol. 225; p. 113752
• Main Authors: Petrov, Stanislav A., Zyk, Nikolay Y., Machulkin, Aleksei E., Beloglazkina, Elena K., Majouga, Alexander G.
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 05.12.2021
• Subjects: Anticancer drugs; Antigens, Surface - chemistry; Antigens, Surface - metabolism; Antineoplastic Combined Chemotherapy Protocols - chemistry; Antineoplastic Combined Chemotherapy Protocols - pharmacology; Cancer diagnosis; Cytostatic Agents - chemistry; Cytostatic Agents - pharmacology; Double conjugates; Glutamate Carboxypeptidase II - antagonists & inhibitors; Glutamate Carboxypeptidase II - chemistry; Glutamate Carboxypeptidase II - metabolism; Humans; Male; Molecular Structure; Molecular Weight; Prostate cancer; Prostatic Neoplasms - diagnosis; Prostatic Neoplasms - drug therapy; PSMA; Targeted delivery; Anticancer drugs; PSMA; Double conjugates; Cancer diagnosis; Targeted delivery; Prostate cancer

This review presents data on dual conjugates of therapeutic and diagnostic action for targeted delivery to prostate cancer cells. The works of the last ten years on this topic were analyzed. The mail attention focuses on low-molecular-weight conjugates directed to the prostate-specific membrane anti...