GSH depletion, mitochondrial membrane breakdown, caspase-3/7 activation and DNA fragmentation in U87MG glioblastoma cells: New insight into the mechanism of cytotoxicity induced by fluoroquinolones - Beberok, Artur; Rzepka, Zuzanna; Respondek, Michalina; Rok, Jakub; Sierotowicz, Daniel; Wrześniok, Dorota (European journal of pharmacology, 2018)
Keywords: Antineoplastic Agents - pharmacology; Apoptosis; Apoptosis - drug effects; Caspase 3 - metabolism; Caspase 7 - metabolism; Cell Line, Tumor; Cell Proliferation - drug effects; Cell Survival - drug effects; Ciprofloxacin; Ciprofloxacin - pharmacology; DNA fragmentation; DNA Fragmentation - drug effects; Enzyme Activation - drug effects; Fluoroquinolones - pharmacology; Glioblastoma - pathology; Glioblastoma multiforme; Glutathione - metabolism; GSH depletion; Humans; Mitochondrial Membranes - drug effects; Moxifloxacin; Moxifloxacin - pharmacology; Moxifloxacin; GSH depletion; Ciprofloxacin; Glioblastoma multiforme; DNA fragmentation; Apoptosis