Mineralocorticoid receptors contribute to ethanol-induced vascular hypercontractility through reactive oxygen species generation and up-regulation of cyclooxygenase 2

• Published in: European journal of pharmacology Vol. 949; p. 175723
• Main Authors: Dourado, Thales M.H., Assis, Victor O., Awata, Wanessa M.C., de Mello, Marcela M.B., Cárnio, Evelin C., Castro, Michele M., Tirapelli, Carlos R.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.06.2023
• Subjects: Animals; Cyclooxygenase 2; Cyclooxygenase 2 - metabolism; Endothelium, Vascular; Ethanol; Ethanol - adverse effects; Hypertension - chemically induced; Hypertension - metabolism; Male; Mineralocorticoid receptors; Rats; Rats, Wistar; Reactive oxygen species; Reactive Oxygen Species - metabolism; Receptors, Mineralocorticoid - metabolism; Thromboxane A2; Up-Regulation; Vasoconstriction; Reactive oxygen species; Ethanol; Mineralocorticoid receptors; Cyclooxygenase 2; Thromboxane A2; Thromboxane A

The effects on blood pressure produced byethanol consumption include both vasoconstriction and activation of the renin-angiotensin-aldosterone system (RAAS), although the detailed relationship between these processes is yet to be accomplished. Here, we sought to investigate the contribution of miner...