Innovative scanning electron microscopic investigation in blood samples of patients affected by leukaemia: A physical-chemical-biological approach
•Electron scanning microscopy: an innovative diagnostic tool.•Leukeamia as a possible result of a tissue nanocontamination.•Nanopollution can induce nano-bio-interaction in the body. The study proposes an innovative, interdisciplinary observation on blood samples of patients coming from the region M...
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| Published in | Micron (Oxford, England : 1993) Vol. 144; p. 103037 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.05.2021
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| Abstract | •Electron scanning microscopy: an innovative diagnostic tool.•Leukeamia as a possible result of a tissue nanocontamination.•Nanopollution can induce nano-bio-interaction in the body.
The study proposes an innovative, interdisciplinary observation on blood samples of patients coming from the region Marche (Italy) suffering from acute myeloid leukaemia (AML) by means of a scanning electron microscope coupled with an X-ray microprobe of an Energy Dispersive Spectroscope. A novel protocol of blood preparation was studied and prepared to identify exogenous, potentially toxic foreign bodies coming from an environmental contamination.
The results on the four different blood fractions of 38 blood samples (erythrocytes, leukocytes, platelets, and plasma) indicate that the circulating blood of leukaemic patients shows the systematic presence of physical contaminants, with a frequency and concentration which are statistically meaningful as compared to the healthy controls. The chemical compositions of the particles were identified as well as the frequency of the elements they were composed of. The analysis of these chemical compositions demonstrated that these patients had undergone a remarkable environmental, occupational, industrial exposure at some time. A possible pathological mechanism based on a nano-bio-interaction between the internalized environmental particulate matter and the blood components is hypothesized and discussed. |
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| AbstractList | The study proposes an innovative, interdisciplinary observation on blood samples of patients coming from the region Marche (Italy) suffering from acute myeloid leukaemia (AML) by means of a scanning electron microscope coupled with an X-ray microprobe of an Energy Dispersive Spectroscope. A novel protocol of blood preparation was studied and prepared to identify exogenous, potentially toxic foreign bodies coming from an environmental contamination. The results on the four different blood fractions of 38 blood samples (erythrocytes, leukocytes, platelets, and plasma) indicate that the circulating blood of leukaemic patients shows the systematic presence of physical contaminants, with a frequency and concentration which are statistically meaningful as compared to the healthy controls. The chemical compositions of the particles were identified as well as the frequency of the elements they were composed of. The analysis of these chemical compositions demonstrated that these patients had undergone a remarkable environmental, occupational, industrial exposure at some time. A possible pathological mechanism based on a nano-bio-interaction between the internalized environmental particulate matter and the blood components is hypothesized and discussed. •Electron scanning microscopy: an innovative diagnostic tool.•Leukeamia as a possible result of a tissue nanocontamination.•Nanopollution can induce nano-bio-interaction in the body. The study proposes an innovative, interdisciplinary observation on blood samples of patients coming from the region Marche (Italy) suffering from acute myeloid leukaemia (AML) by means of a scanning electron microscope coupled with an X-ray microprobe of an Energy Dispersive Spectroscope. A novel protocol of blood preparation was studied and prepared to identify exogenous, potentially toxic foreign bodies coming from an environmental contamination. The results on the four different blood fractions of 38 blood samples (erythrocytes, leukocytes, platelets, and plasma) indicate that the circulating blood of leukaemic patients shows the systematic presence of physical contaminants, with a frequency and concentration which are statistically meaningful as compared to the healthy controls. The chemical compositions of the particles were identified as well as the frequency of the elements they were composed of. The analysis of these chemical compositions demonstrated that these patients had undergone a remarkable environmental, occupational, industrial exposure at some time. A possible pathological mechanism based on a nano-bio-interaction between the internalized environmental particulate matter and the blood components is hypothesized and discussed. |
| ArticleNumber | 103037 |
| Author | Valentini, Laura Manti, Anita Montanari, Stefano Gatti, Antonietta Rocchi, Marco Bruno Luigi |
| Author_xml | – sequence: 1 givenname: Antonietta surname: Gatti fullname: Gatti, Antonietta email: gatti@nanodiagnostics.it organization: Health, Law and Science Association, HLS, c/o Stelior, Quai du Seujet 16-18, Geneve, Switzerland – sequence: 2 givenname: Anita surname: Manti fullname: Manti, Anita organization: New Nanodiagnostics Srl, via E.Fermi 1/L, San Vito, MO, 41051, Italy – sequence: 3 givenname: Laura surname: Valentini fullname: Valentini, Laura organization: University of Urbino Carlo Bo, Via Aurelio Saffi, 2, Urbino, PU, 61029, Italy – sequence: 4 givenname: Marco Bruno Luigi surname: Rocchi fullname: Rocchi, Marco Bruno Luigi organization: University of Urbino Carlo Bo, Via Aurelio Saffi, 2, Urbino, PU, 61029, Italy – sequence: 5 givenname: Stefano surname: Montanari fullname: Montanari, Stefano organization: New Nanodiagnostics Srl, via E.Fermi 1/L, San Vito, MO, 41051, Italy |
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| Cites_doi | 10.1289/ehp.7962 10.1016/S0041-008X(02)00024-8 10.1002/cyto.b.20510 10.1098/rsif.2006.0145 10.1164/rccm.200506-865OC 10.1002/cyto.990130111 10.1007/s00204-008-0313-y 10.1111/j.1365-2141.1976.tb03563.x 10.1021/acs.biomac.5b00108 10.2106/00004623-199409000-00009 10.1016/j.leukres.2016.09.004 10.1007/s10856-008-3385-6 10.1023/A:1017918013293 10.1161/hc0402.104118 10.1021/ja107583h 10.1056/NEJM199312093292401 10.1080/08958370601051727 10.1007/s10006-002-0371-x 10.1002/jor.1100150107 10.1186/1743-8977-3-13 10.1289/ehp.1408973 10.1164/rccm.200602-301OC 10.1002/ajh.25731 10.1093/occmed/kqw134 |
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| Keywords | Nanoparticles Scanning electron microscopy Environment Pollution Toxicity Leukaemia |
| Language | English |
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| Snippet | •Electron scanning microscopy: an innovative diagnostic tool.•Leukeamia as a possible result of a tissue nanocontamination.•Nanopollution can induce... The study proposes an innovative, interdisciplinary observation on blood samples of patients coming from the region Marche (Italy) suffering from acute myeloid... |
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| SubjectTerms | Environment Leukaemia Nanoparticles Pollution Scanning electron microscopy Toxicity |
| Title | Innovative scanning electron microscopic investigation in blood samples of patients affected by leukaemia: A physical-chemical-biological approach |
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