Effect of exenatide on cholecystokinin-induced gallbladder emptying in fasting healthy subjects

• Published in: Regulatory peptides Vol. 179; no. 1-3; pp. 77 - 83
• Main Authors: Keller, Jutta, Trautmann, Michael E., Haber, Harry, Tham, Lai San, Hunt, Tamsin, Mace, Kenneth, Linnebjerg, Helle
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 10.11.2012
• Subjects: Adolescent; Adult; Aged; Bile Ducts - anatomy & histology; Bile Ducts - diagnostic imaging; Blood Glucose - analysis; Cholecystokinin - administration & dosage; Cholecystokinin - pharmacology; Confidence Intervals; Cross-Over Studies; Double-Blind Method; Ejection fraction; Fasting; Female; Gallbladder - diagnostic imaging; Gallbladder - drug effects; Gallbladder - metabolism; Gallbladder Emptying - drug effects; Glucagon-Like Peptide 1 - agonists; Glucagon-like peptide-1; Humans; Least-Squares Analysis; Male; Middle Aged; Organ Size - drug effects; Pancreatic Ducts - anatomy & histology; Pancreatic Ducts - diagnostic imaging; Peptides - administration & dosage; Peptides - pharmacology; Ultrasonography; Venoms - administration & dosage; Venoms - pharmacology; Young Adult; Glucagon-like peptide-1; Ultrasonography; Ejection fraction

Exenatide is a glucagon-like peptide-1 receptor agonist for the treatment of type 2 diabetes and has been shown to lower blood glucose through multiple mechanisms, including glucose-dependent insulin secretion, suppression of postprandial glucagon release and slowing of gastric emptying. The effects...