Identification of glabridin as a bioactive compound in licorice (Glycyrrhiza glabra L.) extract that activates human peroxisome proliferator-activated receptor gamma (PPARγ)

• Published in: Fitoterapia Vol. 106; pp. 55 - 61
• Main Authors: Rebhun, John F., Glynn, Kelly M., Missler, Stephen R.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2015
• Subjects: Animals; CHO Cells; Cricetulus; Gene Expression Regulation; Glabridin; Glycyrrhiza - chemistry; Glycyrrhiza glabra L; Glycyrrhizin; Hep G2 Cells; Humans; Isoflavones - chemistry; Licorice; Licorice extract; Molecular Structure; Peroxisome proliferator-activated receptor gamma (PPARγ); Phenols - chemistry; Plant Extracts - chemistry; Plant Roots - chemistry; PPAR gamma - metabolism; Up-Regulation; Glycyrrhizin; Glabridin; Glabrene; UAS; T0070907; Licorice; Licorice extract; Glycyrrhiza glabra L; Glycyrrhetinic acid; LBD; FABP1; PPAR; Peroxisome proliferator-activated receptor gamma (PPARγ); HMGCS2; HPRT1; PCK1; TR-FRET; Troglitazone

Licorice, the root and stolons of the Glycyrrhiza plant (Fabaceae), has been used for centuries as a food additive (sweetener), in cosmetics, and in traditional medicine. In this research, we provide evidence that licorice extract activates peroxisome proliferator-activated receptor gamma (PPARγ) an...