Influence of resistance to 5-fluorouracil and tomudex on [18F]-FDG incorporation, glucose transport and hexokinase activity

• Published in: International journal of oncology Vol. 41; no. 1; pp. 378 - 382
• Main Authors: LAW, Alison A, COLLIE-DUGUID, Elaina S. R, SMITH, Tim A. D
• Format: Journal Article
• Language: English
• Published: Athens Editorial Academy of the International Journal of Oncology 01.07.2012
• Subjects: 3-O-Methylglucose - metabolism; Antimetabolites, Antineoplastic - pharmacology; Biological and medical sciences; Biological Transport; Cell Line, Tumor; Cell Survival - drug effects; Drug Resistance, Neoplasm; Fluorodeoxyglucose F18 - metabolism; Fluorouracil - pharmacology; Glucose - metabolism; Hexokinase - metabolism; Humans; Medical sciences; Quinazolines - pharmacology; Radiopharmaceuticals - metabolism; Thiophenes - pharmacology; Tumors; Antineoplastic agent; glucose transport; 2-deoxy-2-fluoroglucose; Incorporation; Treatment resistance; Enzyme; Fluoropyrimidine derivatives; Transferases; tomudex; Enzyme inhibitor; Glucose; Thymidylate synthase; fluorodeoxyglucose; Biological activity; Hexokinase; 5-fluorouracil; Cancerology; Antimetabolic; Methyltransferases; Pyrimidine derivatives; drug resistance; Transport; Fluorouracil

Drug resistance is a major obstacle to cancer cure and may influence [18F]-fluorodeoxyglucose (FDG) incorporation. In this study, glucose transport, hexokinase activity and [18F]-FDG incorporation were measured in drug-resistant tumour cells generated by exposing H630 colon and MCF7 breast cancer ce...