In vivo voltage-sensitive dye imaging of the insular cortex in nerve-injured rats

• Published in: Neuroscience letters Vol. 634; pp. 146 - 152
• Main Authors: Han, Jeongsoo, Cha, Myeounghoon, Kwon, Minjee, Hong, Seong-Karp, Bai, Sun Joon, Lee, Bae Hwan
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 10.11.2016
• Subjects: Animals; Cerebral Cortex - diagnostic imaging; Cerebral Cortex - physiopathology; Hyperalgesia - physiopathology; Insular cortex; Male; Nerve injury; Neuralgia - physiopathology; Neuronal Plasticity; Neuropathic pain; Neuroplasticity; Optical imaging; Rats, Sprague-Dawley; Sciatic Nerve - injuries; Voltage-sensitive dye; Voltage-Sensitive Dye Imaging; Neuroplasticity; ACC; POD; VSD; Nerve injury; Optical imaging; Voltage-sensitive dye; PFC; ROI; Neuropathic pain; IC; Insular cortex; S1; S2

•Excitability of the IC to peripheral stimulation is changed after nerve injury.•Optical signals in the IC increased as the stimulation intensity was elevated.•Plastic changes in the IC could be related to nerve injury-chronic pain. The insular cortex (IC) is a pain-related brain region that receive...