10p11.2 to 10q11.2 is a yet unreported region leading to unbalanced chromosomal abnormalities without phenotypic consequences
Directly transmitted unbalanced chromosomal abnormalities (UBCA) or euchromatic variants (EV) were recently reported for >50 euchromatic regions of almost all human autosomes. UBCA and EV are comprised of a few megabases of DNA, and carriers are in many cases clinically healthy. Here we report on...
Saved in:
| Published in | Cytogenetic and genome research Vol. 124; no. 1; pp. 102 - 105 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Basel, Switzerland
S. Karger AG
01.01.2009
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1424-8581 1424-859X 1424-859X |
| DOI | 10.1159/000200094 |
Cover
Loading…
| Abstract | Directly transmitted unbalanced chromosomal abnormalities (UBCA) or euchromatic variants (EV) were recently reported for >50 euchromatic regions of almost all human autosomes. UBCA and EV are comprised of a few megabases of DNA, and carriers are in many cases clinically healthy. Here we report on partial trisomies of chromosome 10 within the pericentromeric region which were detected by standard G banding. Those were referred for further delineation of the size of these duplicated regions for molecular cytogenetics and/or array-CGH. Partial trisomies of chromosome 10 in the pericentromeric region were identified prenatally in seven cases. A maximum of three copies of the region from 10p12.1 to 10q11.22 was observed in all cases without apparent clinical abnormalities. The imbalances were either caused by a direct duplication in one familial case or by de novo small supernumerary marker chromosomes (sSMC). Thus, we report a yet unrecognized chromosomal region subject to UBCA detected in seven unrelated cases. To the best of our knowledge, this is the first report of a UBCA in the pericentromeric region of chromosome 10 that is not correlated with any clinical consequences. |
|---|---|
| AbstractList | Directly transmitted unbalanced chromosomal abnormalities (UBCA) or euchromatic variants (EV) were recently reported for >50 euchromatic regions of almost all human autosomes. UBCA and EV are comprised of a few megabases of DNA, and carriers are in many cases clinically healthy. Here we report on partial trisomies of chromosome 10 within the pericentromeric region which were detected by standard G banding. Those were referred for further delineation of the size of these duplicated regions for molecular cytogenetics and/or array-CGH. Partial trisomies of chromosome 10 in the pericentromeric region were identified prenatally in seven cases. A maximum of three copies of the region from 10p12.1 to 10q11.22 was observed in all cases without apparent clinical abnormalities. The imbalances were either caused by a direct duplication in one familial case or by de novo small supernumerary marker chromosomes (sSMC). Thus, we report a yet unrecognized chromosomal region subject to UBCA detected in seven unrelated cases. To the best of our knowledge, this is the first report of a UBCA in the pericentromeric region of chromosome 10 that is not correlated with any clinical consequences. Copyright copyright 2009 S. Karger AG, Basel Directly transmitted unbalanced chromosomal abnormalities (UBCA) or euchromatic variants (EV) were recently reported for >50 euchromatic regions of almost all human autosomes. UBCA and EV are comprised of a few megabases of DNA, and carriers are in many cases clinically healthy. Here we report on partial trisomies of chromosome 10 within the pericentromeric region which were detected by standard G banding. Those were referred for further delineation of the size of these duplicated regions for molecular cytogenetics and/or array-CGH. Partial trisomies of chromosome 10 in the pericentromeric region were identified prenatally in seven cases. A maximum of three copies of the region from 10p12.1 to 10q11.22 was observed in all cases without apparent clinical abnormalities. The imbalances were either caused by a direct duplication in one familial case or by de novo small supernumerary marker chromosomes (sSMC). Thus, we report a yet unrecognized chromosomal region subject to UBCA detected in seven unrelated cases. To the best of our knowledge, this is the first report of a UBCA in the pericentromeric region of chromosome 10 that is not correlated with any clinical consequences.Directly transmitted unbalanced chromosomal abnormalities (UBCA) or euchromatic variants (EV) were recently reported for >50 euchromatic regions of almost all human autosomes. UBCA and EV are comprised of a few megabases of DNA, and carriers are in many cases clinically healthy. Here we report on partial trisomies of chromosome 10 within the pericentromeric region which were detected by standard G banding. Those were referred for further delineation of the size of these duplicated regions for molecular cytogenetics and/or array-CGH. Partial trisomies of chromosome 10 in the pericentromeric region were identified prenatally in seven cases. A maximum of three copies of the region from 10p12.1 to 10q11.22 was observed in all cases without apparent clinical abnormalities. The imbalances were either caused by a direct duplication in one familial case or by de novo small supernumerary marker chromosomes (sSMC). Thus, we report a yet unrecognized chromosomal region subject to UBCA detected in seven unrelated cases. To the best of our knowledge, this is the first report of a UBCA in the pericentromeric region of chromosome 10 that is not correlated with any clinical consequences. Directly transmitted unbalanced chromosomal abnormalities (UBCA) or euchromatic variants (EV) were recently reported for >50 euchromatic regions of almost all human autosomes. UBCA and EV are comprised of a few megabases of DNA, and carriers are in many cases clinically healthy. Here we report on partial trisomies of chromosome 10 within the pericentromeric region which were detected by standard G banding. Those were referred for further delineation of the size of these duplicated regions for molecular cytogenetics and/or array-CGH. Partial trisomies of chromosome 10 in the pericentromeric region were identified prenatally in seven cases. A maximum of three copies of the region from 10p12.1 to 10q11.22 was observed in all cases without apparent clinical abnormalities. The imbalances were either caused by a direct duplication in one familial case or by de novo small supernumerary marker chromosomes (sSMC). Thus, we report a yet unrecognized chromosomal region subject to UBCA detected in seven unrelated cases. To the best of our knowledge, this is the first report of a UBCA in the pericentromeric region of chromosome 10 that is not correlated with any clinical consequences. Directly transmitted unbalanced chromosomal abnormalities (UBCA) or euchromatic variants (EV) were recently reported for >50 euchromatic regions of almost all human autosomes. UBCA and EV are comprised of a few megabases of DNA, and carriers are in many cases clinically healthy. Here we report on partial trisomies of chromosome 10 within the pericentromeric region which were detected by standard G banding. Those were referred for further delineation of the size of these duplicated regions for molecular cytogenetics and/or array-CGH. Partial trisomies of chromosome 10 in the pericentromeric region were identified prenatally in seven cases. A maximum of three copies of the region from 10p12.1 to 10q11.22 was observed in all cases without apparent clinical abnormalities. The imbalances were either caused by a direct duplication in one familial case or by de novo small supernumerary marker chromosomes (sSMC). Thus, we report a yet unrecognized chromosomal region subject to UBCA detected in seven unrelated cases. To the best of our knowledge, this is the first report of a UBCA in the pericentromeric region of chromosome 10 that is not correlated with any clinical consequences. Copyright © 2009 S. Karger AG, Basel [PUBLICATION ABSTRACT] |
| Author | Cai, W.W. Patsalis, P.C. Weise, A. Klaschka, V. Hinreiner, S. Bhatt, S. Stumm, M. Meins, M. Liehr, T. Mrasek, K. Wegner, R.D. Ewers, E. Hickmann, P. Kosyakova, N. Morlot, S. Cheung, S.W. |
| Author_xml | – sequence: 1 givenname: T. surname: Liehr fullname: Liehr, T. – sequence: 2 givenname: M. surname: Stumm fullname: Stumm, M. – sequence: 3 givenname: R.D. surname: Wegner fullname: Wegner, R.D. – sequence: 4 givenname: S. surname: Bhatt fullname: Bhatt, S. – sequence: 5 givenname: P. surname: Hickmann fullname: Hickmann, P. – sequence: 6 givenname: P.C. surname: Patsalis fullname: Patsalis, P.C. – sequence: 7 givenname: M. surname: Meins fullname: Meins, M. – sequence: 8 givenname: S. surname: Morlot fullname: Morlot, S. – sequence: 9 givenname: V. surname: Klaschka fullname: Klaschka, V. – sequence: 10 givenname: E. surname: Ewers fullname: Ewers, E. – sequence: 11 givenname: S. surname: Hinreiner fullname: Hinreiner, S. – sequence: 12 givenname: K. surname: Mrasek fullname: Mrasek, K. – sequence: 13 givenname: N. surname: Kosyakova fullname: Kosyakova, N. – sequence: 14 givenname: W.W. surname: Cai fullname: Cai, W.W. – sequence: 15 givenname: S.W. surname: Cheung fullname: Cheung, S.W. – sequence: 16 givenname: A. surname: Weise fullname: Weise, A. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19372675$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkc1LIzEYxoMoart78C4S9rCwh9okM5mPoxTdXSh4UdhbyCTvtNGZZEwyLD34v5vabg-y4CHkgff3Pu_XBB1bZwGhC0quKeX1nBDC0qvzI3ROc5bPKl7_OT7oip6hSQhPhNAq58UpOqN1VrKi5OfolZKB0muGo8OUvLxLE7DEG4h4tB4G5yNo7GFlnMUdSG3sakuPtpGdtCoF1dq73gXXyw7LxjqfhIkGAv5r4tqNEQ9rsC5uBqOwcjbAywgpM3xBJ63sAnzd_1P0eHf7sPg1W97__L24Wc5UVrA407poZdtyQnPNGsUbUmalrsumqpq21ppKwlhe5y1wqYkG1vJSFppXFec6U3k2Rd93voN3qXSIojdBQZf6BzcGUZQ0SwblpyAjNeUF4wn89gF8cqO3aQiRWmEZL6pt2as9NDY9aDF400u_Ef_Wn4D5DlDeheChFcpEGdOmo5emE5SI7YHF4cAp48eHjIPpf9jLHfss_Qr8gdyH3wDb5a1s |
| CitedBy_id | crossref_primary_10_3109_08990220_2015_1086327 crossref_primary_10_1186_s13039_022_00598_x crossref_primary_10_24075_brsmu_2024_001 crossref_primary_10_1186_s13039_022_00614_0 crossref_primary_10_1007_s10803_011_1398_3 crossref_primary_10_1186_1755_8166_4_1 crossref_primary_10_1159_000444600 crossref_primary_10_3892_etm_2014_1520 crossref_primary_10_1002_ajmg_a_33080 crossref_primary_10_1016_j_tjog_2024_08_004 crossref_primary_10_1177_03000605241271837 crossref_primary_10_3109_14767058_2012_732129 crossref_primary_10_1186_1755_8166_6_45 |
| Cites_doi | 10.1093%2Fhmg%2F8.2.205 10.1136%2Fjmg.2004.026955 10.1038%2Fng1416 10.1007%2Fs00439-003-1016-3 10.1007%2Fs004390100459 10.1007%2FBF03194675 |
| ContentType | Journal Article |
| Copyright | 2009 S. Karger AG, Basel Copyright 2009 S. Karger AG, Basel. Copyright (c) 2009 S. Karger AG, Basel |
| Copyright_xml | – notice: 2009 S. Karger AG, Basel – notice: Copyright 2009 S. Karger AG, Basel. – notice: Copyright (c) 2009 S. Karger AG, Basel |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QP 7TK 7X7 7XB 88A 88E 88I 8AF 8AO 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2P M7P P64 PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS Q9U RC3 S0X 7X8 |
| DOI | 10.1159/000200094 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Calcium & Calcified Tissue Abstracts Neurosciences Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest STEM Database ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni) Medical Database Science Database Biological Science Database Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic Genetics Abstracts SIRS Editorial MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Central Student Technology Research Database ProQuest One Academic Middle East (New) ProQuest Central Essentials SIRS Editorial ProQuest Health & Medical Complete (Alumni) ProQuest AP Science ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Genetics Abstracts Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Genetics Abstracts MEDLINE - Academic CrossRef MEDLINE ProQuest Central Student |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1424-859X |
| EndPage | 105 |
| ExternalDocumentID | 1686561021 19372675 10_1159_000200094 200094 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Case Reports Report Case Study |
| GroupedDBID | --- -~X .GJ 0R~ 0~5 0~B 29F 30W 326 34G 36B 39C 3O- 3O. 3V. 4.4 53G 5GY 5RE 7X7 88A 88E 88I 8AF 8AO 8FE 8FH 8FI 8FJ 8UI AAYIC ABJNI ABPAZ ABUWG ACGFO ACGFS ACGOD ACPRK ACPSR ADBBV AENEX AEYAO AFFNX AFJJK AFKRA AHMBA ALDHI ALIPV ALMA_UNASSIGNED_HOLDINGS AZPMC AZQEC BBNVY BENPR BES BHPHI BPHCQ BVXVI CAG CCPQU COF CS3 CYUIP DU5 DWQXO E0A EBS EJD EMB EMOBN F5P FB. FYUFA GNUQQ HCIFZ HMCUK HZ~ IH2 IY7 KUZGX L7B LK8 M0L M1P M2P M7P O1H O9- PQQKQ PROAC PSQYO RIG RKO RXVBD S0X SV3 UJ6 UKHRP ZGI AAYXX ABBTS ABWCG AHFRZ CITATION PHGZM PHGZT CGR CUY CVF ECM EIF NPM PJZUB PPXIY PQGLB 7QP 7TK 7XB 8FD 8FK FR3 K9. P64 PKEHL PQEST PQUKI PRINS Q9U RC3 PUEGO 7X8 |
| ID | FETCH-LOGICAL-c362t-dd6faff5014d2bc5b0737d97b88bf9dd1a022494fe5ad0de2f57a6d58855d3c43 |
| IEDL.DBID | BENPR |
| ISSN | 1424-8581 1424-859X |
| IngestDate | Thu Sep 04 18:55:49 EDT 2025 Fri Sep 05 08:20:49 EDT 2025 Sat Aug 16 21:34:17 EDT 2025 Mon Jul 21 05:16:25 EDT 2025 Tue Jul 01 04:58:40 EDT 2025 Thu Apr 24 23:04:39 EDT 2025 Thu Aug 29 12:04:37 EDT 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. https://www.karger.com/Services/SiteLicenses Copyright 2009 S. Karger AG, Basel. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c362t-dd6faff5014d2bc5b0737d97b88bf9dd1a022494fe5ad0de2f57a6d58855d3c43 |
| Notes | ObjectType-Case Study-2 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Report-1 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 ObjectType-Feature-4 ObjectType-Article-3 |
| PMID | 19372675 |
| PQID | 224235684 |
| PQPubID | 27467 |
| PageCount | 4 |
| ParticipantIDs | proquest_miscellaneous_67132497 proquest_journals_224235684 karger_primary_200094 pubmed_primary_19372675 crossref_primary_10_1159_000200094 crossref_citationtrail_10_1159_000200094 proquest_miscellaneous_20915625 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2009-01-01 |
| PublicationDateYYYYMMDD | 2009-01-01 |
| PublicationDate_xml | – month: 01 year: 2009 text: 2009-01-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | Basel, Switzerland |
| PublicationPlace_xml | – name: Basel, Switzerland – name: Switzerland – name: Basel |
| PublicationTitle | Cytogenetic and genome research |
| PublicationTitleAlternate | Cytogenet Genome Res |
| PublicationYear | 2009 |
| Publisher | S. Karger AG |
| Publisher_xml | – name: S. Karger AG |
| References | Barber JC: Directly transmitted unbalanced chromosome abnormalities and euchromatic variants. J Med Genet 42:609-629 (2005).1606156010.1136%2Fjmg.2004.026955 Iafrate AJ, Feuk L, Rivera MN, Listewnik ML, Donahoe PK, et al: Detection of large-scale variation in the human genome. Nat Genet 36:949-951 (2004).1528678910.1038%2Fng1416 Pietrzak J, Mrasek K, Obersztyn E, Stankiewicz P, Kosyakova N, et al: Molecular cytogenetic characterization of eight small supernumerary marker chromosomes originating from chromosomes 2, 4, 8, 18, and 21 in three patients. J Appl Genet 48:167-175 (2007).1749535110.1007%2FBF03194675 Barber JC: Unbalanced chromosome abnormality (UBCA) Chart. https://www.som.soton.ac.uk/research/Geneticsdiv/anomaly%20re- gister/default.htm (2008). Liehr T: Small supernumerary marker chromosomes (sSMC). http://www.med.uni-jena.de/fish/sSMC/00START.htm (2008). Jackson MS, Rocchi M, Thompson G, Hearn T, Crosier M, et al: Sequences flanking the centromere of human chromosome 10 are a complex patchwork of arm-specific sequences, stable duplications and unstable sequences with homologies to telomeric and other centromeric locations. Hum Mol Genet 8:205-215 (1999).993132810.1093%2Fhmg%2F8.2.205 Nietzel A, Rocchi M, Starke H, Heller A, Fiedler W, et al: A new multicolor-FISH approach for the characterization of marker chromosomes: centromere-specific multicolor-FISH (cenM-FISH). Hum Genet 108:199-204 (2001).1135463010.1007%2Fs004390100459 Starke H, Nietzel A, Weise A, Heller A, Mrasek K, et al: Small supernumerary marker chromosomes (SMCs): genotype-phenotype correlation and classification. Hum Genet 114:51-67 (2003).1368036210.1007%2Fs00439-003-1016-3 ref2 ref1 ref4 ref3 ref6 ref5 |
| References_xml | – reference: Pietrzak J, Mrasek K, Obersztyn E, Stankiewicz P, Kosyakova N, et al: Molecular cytogenetic characterization of eight small supernumerary marker chromosomes originating from chromosomes 2, 4, 8, 18, and 21 in three patients. J Appl Genet 48:167-175 (2007).1749535110.1007%2FBF03194675 – reference: Barber JC: Directly transmitted unbalanced chromosome abnormalities and euchromatic variants. J Med Genet 42:609-629 (2005).1606156010.1136%2Fjmg.2004.026955 – reference: Nietzel A, Rocchi M, Starke H, Heller A, Fiedler W, et al: A new multicolor-FISH approach for the characterization of marker chromosomes: centromere-specific multicolor-FISH (cenM-FISH). Hum Genet 108:199-204 (2001).1135463010.1007%2Fs004390100459 – reference: Barber JC: Unbalanced chromosome abnormality (UBCA) Chart. https://www.som.soton.ac.uk/research/Geneticsdiv/anomaly%20re- gister/default.htm (2008). – reference: Iafrate AJ, Feuk L, Rivera MN, Listewnik ML, Donahoe PK, et al: Detection of large-scale variation in the human genome. Nat Genet 36:949-951 (2004).1528678910.1038%2Fng1416 – reference: Liehr T: Small supernumerary marker chromosomes (sSMC). http://www.med.uni-jena.de/fish/sSMC/00START.htm (2008). – reference: Starke H, Nietzel A, Weise A, Heller A, Mrasek K, et al: Small supernumerary marker chromosomes (SMCs): genotype-phenotype correlation and classification. Hum Genet 114:51-67 (2003).1368036210.1007%2Fs00439-003-1016-3 – reference: Jackson MS, Rocchi M, Thompson G, Hearn T, Crosier M, et al: Sequences flanking the centromere of human chromosome 10 are a complex patchwork of arm-specific sequences, stable duplications and unstable sequences with homologies to telomeric and other centromeric locations. Hum Mol Genet 8:205-215 (1999).993132810.1093%2Fhmg%2F8.2.205 – ident: ref3 doi: 10.1093%2Fhmg%2F8.2.205 – ident: ref1 doi: 10.1136%2Fjmg.2004.026955 – ident: ref2 doi: 10.1038%2Fng1416 – ident: ref6 doi: 10.1007%2Fs00439-003-1016-3 – ident: ref4 doi: 10.1007%2Fs004390100459 – ident: ref5 doi: 10.1007%2FBF03194675 |
| SSID | ssj0018456 |
| Score | 1.958459 |
| Snippet | Directly transmitted unbalanced chromosomal abnormalities (UBCA) or euchromatic variants (EV) were recently reported for >50 euchromatic regions of almost all... |
| SourceID | proquest pubmed crossref karger |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 102 |
| SubjectTerms | Amniocentesis Chromosome Aberrations Chromosome Banding Chromosome Breakage Chromosomes, Human, Pair 10 Comparative Genomic Hybridization Female Gene Dosage Gene Duplication Genetic Markers Humans In Situ Hybridization, Fluorescence Karyotyping Male Microdissection Oligonucleotide Array Sequence Analysis Phenotype Physical Chromosome Mapping Prenatal Diagnosis Short Report |
| Title | 10p11.2 to 10q11.2 is a yet unreported region leading to unbalanced chromosomal abnormalities without phenotypic consequences |
| URI | https://karger.com/doi/10.1159/000200094 https://www.ncbi.nlm.nih.gov/pubmed/19372675 https://www.proquest.com/docview/224235684 https://www.proquest.com/docview/20915625 https://www.proquest.com/docview/67132497 |
| Volume | 124 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3faxQxEB7stYIvorbqWa1B-tCX0NvdZJM8iUpLESwiFu5t2fyixXP32tt9uAf_dzOb3NpC69uSDGTJJJmZfF9mAA5NoU2wEoKqQnvKytxR6WRB8RVomSsvvMHXyN_Oy7ML9nXO54mbs0q0ys2ZOBzUtjV4R36co-HnpWQfl9cUi0YhuJoqaGzBdjiBJZ_A9ueT8-8_RhhBMh6fF-WMSi6zlFoomPDjAYNDXt0dg7TzC_nXNw-7m4PZOX0GT5O_SD5FBT-HR655AY9jBcn1LvzJZsssBKCka0k2ux4-r1akJmvXkb6JiICzBOsvtA1ZRMo8SveNRlajCZ3mEjl5q_Z3GKjWDXqxiyHRKsFb2rbvCBLB2m69vDLE3KJf78HF6cnPL2c0VVSgJhiqjlpb-tp7xBJtrg3XYYMLq4SWUntlbVajSVfMO17bmXW556IuLZeSc1sYVryESdM27jWQ0kmjtLBZUTvGvJLGySzzTM289MzJKRxtprUyKd04Vr1YVEPYwVU1amAKH0bRZcyxcZ_QXtTNKLJp39-oqkrbb1WNi2UK78fesG8QDKkb1_ZBJDhKGPw9LFGG-D1MhpjCq7gC_v1c8OnyEGm9-e_Y-_AkQk94X_MWJt1N794FD6bTB7Al5uIgrda_94_v-w |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELZKC4IL4lFgKVALgcTF6iaxE_uAEI9WW9quEGql3tL4Japuk203EdoDP4n_yEycBJAot96ieBRHnhnPN57xDCGvTKINWImMqUR7xtPYMelkwvAWaBorn3mDt5EPpunkiH8-Fscr5Gd_FwbTKvs9sd2obWXwjHwrRsMvUsnfzS8YNo3C4GrfQSNIxZ5bfgePbfF29xOw93Uc72wffpywrqkAM7BX18za1BfeYzjNxtoIDTKeWZVpKbVX1kYFWjXFvROFHVsXe5EVqRVSCmETwxP47g2yBihDgRKtfdiefvk6hC0kF-E6U8yZFDLqShkBZNhqY36Yx_eXAbx5hvnel1fD29bM7dwjdzt8St8HgbpPVlz5gNwKHSuXD8mPaDyPwOGldUWj8UX7eLqgBV26mjZliEA4S7HfQ1XSWUjRR-qm1JhFaWDQfMMcwEV1DhMVukTUPGsLu1I8Fa6ammLiWVUv56eGmj_SvdfJ0bUs9iOyWlale0Jo6qRROrNRUjjOvZLGySjyXI299NzJEXnTL2tuuvLm2GVjlrdujlD5wIEReTmQzkNNj38RrQfeDCT9-42eVXmn7ot8EM4R2RxGQU8x-FKUrmqABIAZOptXU6RZBOhWZSPyOEjA758DDBmDZ_f0v3NvktuTw4P9fH93urdB7oSwF54VPSOr9WXjngN6qvWLTmYpObluNfkFn1AtaA |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VLSAuiEeBpUAtBBIXazeJndgHhIB21VJYVYhKvYX4JSqWZNtNhPbAD-Pf4YmTABLl1lsUj-LIM-OZ8XyeAXimE6W9lcioTJSjLI0tFVYkFG-BprF0mdN4G_nDPN0_Zu9O-MkG_OzvwiCsst8T243aVBrPyCcxGn6eCjZxHSriaHf2anlGsYEUJlr7bhpBQg7t-ruP3lYvD3Y9q5_H8Wzv09t92jUYoNrv2zU1JnWFc5haM7HSXHl5z4zMlBDKSWOiAi2cZM7ywkyNjR3PitRwITg3iWaJ_-4V2My8URQj2HyzNz_6OKQwBOPhalPMqOAi6soaefdh0ub_ENP3lzG8-hWx3-cXu7qtyZvdgpudr0peB-G6DRu2vAPXQvfK9V34EU2XkQ9-SV2RaHrWPp6uSEHWtiZNGbIR1hDs_VCVZBHg-kjdlAoRldoP6i-IB1xV3_xEhSrRg160RV4JnhBXTU0QhFbV6-WpJvoP6PcWHF_KYt-DUVmV9gGQ1AotVWaipLCMOSm0FVHkmJw64ZgVY3jRL2uuu1Ln2HFjkbchD5f5wIExPB1Il6G-x7-ItgJvBpL-_XbPqrxT_VU-COoYdoZRr7OYiClKWzWexDtpGHheTJFmkfd0ZTaG-0ECfv-c9ydjH-U9_O_cO3Ddq0f-_mB-uA03QgYMj40ewag-b-xj70jV6kknsgQ-X7aW_AJm-DGU |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=10p11.2+to+10q11.2+is+a+yet+unreported+region+leading+to+unbalanced+chromosomal+abnormalities+without+phenotypic+consequences&rft.jtitle=Cytogenetic+and+genome+research&rft.au=Liehr%2C+T&rft.au=Stumm%2C+M&rft.au=Wegner%2C+R+D&rft.au=Bhatt%2C+S&rft.date=2009-01-01&rft.eissn=1424-859X&rft.volume=124&rft.issue=1&rft.spage=102&rft_id=info:doi/10.1159%2F000200094&rft_id=info%3Apmid%2F19372675&rft.externalDocID=19372675 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1424-8581&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1424-8581&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1424-8581&client=summon |