Differentiation of skeletal osteogenic progenitor cells to osteoblasts with 3,4-diarylbenzopyran based amide derivatives: Novel osteogenic agents

• Published in: European journal of medicinal chemistry Vol. 121; pp. 82 - 99
• Main Authors: Gupta, Atul, Ahmad, Imran, Kureel, Jyoti, John, Aijaz A., Sultan, Eram, Chanda, Debabrata, Agarwal, Naresh Kumar, Alauddin, Wahajuddin, Prabhaker, S., Verma, Amita, Singh, Divya
• Format: Journal Article
• Language: English
• Published: ISSY-LES-MOULINEAUX Elsevier Masson SAS 04.10.2016; Elsevier
• Subjects: Amides - chemistry; Amides - pharmacokinetics; Amides - pharmacology; Animals; Antiosteoporotic; Benzopyran; Benzopyrans - chemistry; Benzopyrans - pharmacokinetics; Benzopyrans - pharmacology; Biological Availability; Cell Differentiation - drug effects; Chemistry, Medicinal; Estrogen; Estrogen Receptor beta - metabolism; Isoflavone; Life Sciences & Biomedicine; Mice; Mice, Inbred BALB C; Osteoblasts - cytology; Osteogenesis - drug effects; Osteogenic; Osteoporosis - chemically induced; Pharmacology & Pharmacy; Science & Technology; Stem Cells - cytology; Structure-Activity Relationship; Isoflavone; Osteogenic; Benzopyran; Antiosteoporotic; Estrogen; IPRIFLAVONE; MECHANISMS; GENISTEIN; BONE-RESORPTION; BREAST-CANCER; ISOFLAVONES; POSTMENOPAUSAL OSTEOPOROSIS; EQUOL; DAIDZEIN; ESTROGEN-RECEPTOR-ALPHA

A series of 3,4-diarylbenzopyran based amide derivatives was synthesized and evaluated for osteogenic activity in in vitro and in vivo models of osteoporosis. Compounds 17a, 21b–c and 22a–b showed significant osteogenic activity in osteoblast differentiation assay. Among the synthesized compounds, 2...