Differentiation of skeletal osteogenic progenitor cells to osteoblasts with 3,4-diarylbenzopyran based amide derivatives: Novel osteogenic agents

A series of 3,4-diarylbenzopyran based amide derivatives was synthesized and evaluated for osteogenic activity in in vitro and in vivo models of osteoporosis. Compounds 17a, 21b–c and 22a–b showed significant osteogenic activity in osteoblast differentiation assay. Among the synthesized compounds, 2...

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Published inEuropean journal of medicinal chemistry Vol. 121; pp. 82 - 99
Main Authors Gupta, Atul, Ahmad, Imran, Kureel, Jyoti, John, Aijaz A., Sultan, Eram, Chanda, Debabrata, Agarwal, Naresh Kumar, Alauddin, Wahajuddin, Prabhaker, S., Verma, Amita, Singh, Divya
Format Journal Article
LanguageEnglish
Published ISSY-LES-MOULINEAUX Elsevier Masson SAS 04.10.2016
Elsevier
Subjects
Amides - chemistry
Amides - pharmacokinetics
Amides - pharmacology
Animals
Antiosteoporotic
Benzopyran
Benzopyrans - chemistry
Benzopyrans - pharmacokinetics
Benzopyrans - pharmacology
Biological Availability
Cell Differentiation - drug effects
Chemistry, Medicinal
Estrogen
Estrogen Receptor beta - metabolism
Isoflavone
Life Sciences & Biomedicine
Mice
Mice, Inbred BALB C
Osteoblasts - cytology
Osteogenesis - drug effects
Osteogenic
Osteoporosis - chemically induced
Pharmacology & Pharmacy
Science & Technology
Stem Cells - cytology
Structure-Activity Relationship
Isoflavone
Osteogenic
Benzopyran
Antiosteoporotic
Estrogen
IPRIFLAVONE
MECHANISMS
GENISTEIN
BONE-RESORPTION
BREAST-CANCER
ISOFLAVONES
POSTMENOPAUSAL OSTEOPOROSIS
EQUOL
DAIDZEIN
ESTROGEN-RECEPTOR-ALPHA
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Abstract A series of 3,4-diarylbenzopyran based amide derivatives was synthesized and evaluated for osteogenic activity in in vitro and in vivo models of osteoporosis. Compounds 17a, 21b–c and 22a–b showed significant osteogenic activity in osteoblast differentiation assay. Among the synthesized compounds, 22b was identified as lead molecule which showed significant osteogenic activity at 1 pM concentration in osteoblast differentiation assay and at 1 mg kg−1 body weight dose in estrogen deficient balb/c mice model. In vitro bone mineralization and expression of osteogenic marker genes viz BMP-2, RUNX-2, OCN, and collagen type 1 further confirmed the osteogenic potential of 22b. Gene expression study for estrogen receptor α and β (ER-α and ER-β) in mouse calvarial osteoblasts (MCOs) unveiled that possibly 22b exerted osteogenic efficacy via activation of Estrogen receptor-β preferentially. In vivo pharmacokinetic, estrogenicity and acute toxicity studies of 22b showed that it had good bioavailability and was devoid of uterine estrogenicity at 1 mg kg−1 and inherent toxicity up to 1000 mg kg−1 body weight dose respectively. [Display omitted] •3,4-diarylbenzopyran based amide derivatives as novel osteogenic agents were identified.•22b showed osteogenic activity at 1 pM in osteoblast differentiation assay and at 1 mg kg−1 body weight dose in estrogen deficient balb/c mice model.•Bone mineralization and expression of osteogenic marker genes confirmed osteogenic potential of 22b.•22b showed good bioavailability and devoid of uterine estrogenicity at 1 mg kg−1in-vivo.•22b had no inherent toxicity up to 1000 mg kg−1 body weight dose in in-vivo model respectively.
AbstractList A series of 3,4-diarylbenzopyran based amide derivatives was synthesized and evaluated for osteogenic activity in in vitro and in vivo models of osteoporosis. Compounds 17a, 21b–c and 22a–b showed significant osteogenic activity in osteoblast differentiation assay. Among the synthesized compounds, 22b was identified as lead molecule which showed significant osteogenic activity at 1 pM concentration in osteoblast differentiation assay and at 1 mg kg−1 body weight dose in estrogen deficient balb/c mice model. In vitro bone mineralization and expression of osteogenic marker genes viz BMP-2, RUNX-2, OCN, and collagen type 1 further confirmed the osteogenic potential of 22b. Gene expression study for estrogen receptor α and β (ER-α and ER-β) in mouse calvarial osteoblasts (MCOs) unveiled that possibly 22b exerted osteogenic efficacy via activation of Estrogen receptor-β preferentially. In vivo pharmacokinetic, estrogenicity and acute toxicity studies of 22b showed that it had good bioavailability and was devoid of uterine estrogenicity at 1 mg kg−1 and inherent toxicity up to 1000 mg kg−1 body weight dose respectively. [Display omitted] •3,4-diarylbenzopyran based amide derivatives as novel osteogenic agents were identified.•22b showed osteogenic activity at 1 pM in osteoblast differentiation assay and at 1 mg kg−1 body weight dose in estrogen deficient balb/c mice model.•Bone mineralization and expression of osteogenic marker genes confirmed osteogenic potential of 22b.•22b showed good bioavailability and devoid of uterine estrogenicity at 1 mg kg−1in-vivo.•22b had no inherent toxicity up to 1000 mg kg−1 body weight dose in in-vivo model respectively.
A series of 3,4-diarylbenzopyran based amide derivatives was synthesized and evaluated for osteogenic activity in in vitro and in vivo models of osteoporosis. Compounds 17a, 21b-c and 22a-b showed significant osteogenic activity in osteoblast differentiation assay. Among the synthesized compounds, 22b was identified as lead molecule which showed significant osteogenic activity at 1 pM concentration in osteoblast differentiation assay and at 1 mg kg(-1) body weight dose in estrogen deficient balb/c mice model. In vitro bone mineralization and expression of osteogenic marker genes viz BMP-2, RUNX-2, OCN, and collagen type 1 further confirmed the osteogenic potential of 22b. Gene expression study for estrogen receptor α and β (ER-α and ER-β) in mouse calvarial osteoblasts (MCOs) unveiled that possibly 22b exerted osteogenic efficacy via activation of Estrogen receptor-β preferentially. In vivo pharmacokinetic, estrogenicity and acute toxicity studies of 22b showed that it had good bioavailability and was devoid of uterine estrogenicity at 1 mg kg(-1) and inherent toxicity up to 1000 mg kg(-1) body weight dose respectively.
A series of 3,4-diarylbenzopyran based amide derivatives was synthesized and evaluated for osteogenic activity in in vitro and in vivo models of osteoporosis. Compounds 17a, 21b-c and 22a-b showed significant osteogenic activity in osteoblast differentiation assay. Among the synthesized compounds, 22b was identified as lead molecule which showed significant osteogenic activity at 1 pM concentration in osteoblast differentiation assay and at 1 mg kg(-1) body weight dose in estrogen deficient balb/c mice model. In vitro bone mineralization and expression of osteogenic marker genes viz BMP-2, RUNX-2, OCN, and collagen type 1 further confirmed the osteogenic potential of 22b. Gene expression study for estrogen receptor a and 13 (ER-alpha and ER-beta) in mouse calvarial osteoblasts (MCOs) unveiled that possibly 22b exerted osteogenic efficacy via activation of Estrogen receptor-beta preferentially. In vivo pharmacokinetic, estrogenicity and acute toxicity studies of 22b showed that it had good bioavailability and was devoid of uterine estrogenicity at 1 mg kg(-1) and inherent toxicity up to 1000 mg kg(-1) body weight dose respectively. 2016 Elsevier Masson SAS. All rights reserved.
Author Kureel, Jyoti
Sultan, Eram
Chanda, Debabrata
John, Aijaz A.
Gupta, Atul
Alauddin
Wahajuddin
Singh, Divya
Verma, Amita
Prabhaker, S.
Agarwal, Naresh Kumar
Ahmad, Imran
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  givenname: Atul
  surname: Gupta
  fullname: Gupta, Atul
  email: atisky2001@yahoo.co.in
  organization: Medicinal Chemistry Department, CSIR-Central Institute of Medicinal and Aromatic Plants, PO. CIMAP, Kukrail Road, Lucknow, 226015, India
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  surname: Ahmad
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  organization: Medicinal Chemistry Department, CSIR-Central Institute of Medicinal and Aromatic Plants, PO. CIMAP, Kukrail Road, Lucknow, 226015, India
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  surname: Kureel
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  organization: Division of Endocrinology, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Lucknow, 226031, India
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  givenname: Aijaz A.
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  organization: Division of Endocrinology, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Lucknow, 226031, India
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  givenname: Debabrata
  surname: Chanda
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  givenname: Naresh Kumar
  surname: Agarwal
  fullname: Agarwal, Naresh Kumar
  organization: Division of Pharmacokinetics and Metabolism, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Lucknow, 226031, India
– sequence: 8
  surname: Alauddin
  fullname: Alauddin
  organization: Division of Pharmacokinetics and Metabolism, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Lucknow, 226031, India
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  surname: Wahajuddin
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– sequence: 10
  givenname: S.
  surname: Prabhaker
  fullname: Prabhaker, S.
  organization: National Centre for Mass Spectrometry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500 007, India
– sequence: 11
  givenname: Amita
  surname: Verma
  fullname: Verma, Amita
  organization: Medicinal Chemistry Department, CSIR-Central Institute of Medicinal and Aromatic Plants, PO. CIMAP, Kukrail Road, Lucknow, 226015, India
– sequence: 12
  givenname: Divya
  surname: Singh
  fullname: Singh, Divya
  organization: Division of Endocrinology, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Lucknow, 226031, India
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Cites_doi 10.1021/ml400397k
10.1039/c3ra45749d
10.1016/j.fct.2007.04.010
10.1016/j.maturitas.2015.07.003
10.1080/08977190412331279890
10.1016/j.bmc.2005.04.082
10.1016/j.tem.2012.03.008
10.1016/j.bmc.2003.11.035
10.1016/j.bmc.2004.05.015
10.2215/CJN.04151206
10.1007/s12020-011-9570-2
10.1186/scrt493
10.1210/me.2014-1316
10.1016/j.ejmech.2009.02.025
10.1016/j.tem.2012.05.005
10.1016/j.jsbmb.2016.01.010
10.1210/jc.2008-1422
10.1016/j.molmed.2004.12.004
10.1002/jbmr.2286
10.1016/j.ecl.2015.05.002
10.1016/j.phymed.2012.12.021
10.1016/j.bmcl.2010.12.008
10.1016/j.bone.2015.05.025
10.1210/er.2007-0014
10.1016/j.phymed.2009.10.004
10.1002/jbmr.2301
10.1016/j.steroids.2014.12.010
10.1016/j.jnutbio.2010.11.002
10.1007/s40265-015-0417-7
10.1021/np500417d
10.1210/endo.142.6.8220
10.1039/C3RA45749D
10.1016/S0969-2126(01)00568-8
10.1021/jm00224a014
10.1210/endo.142.12.8536
10.3177/jnsv.61.S139
10.1093/jn/134.10.2623
10.1126/science.3201241
10.1016/S0169-6009(08)80099-2
10.1021/jm980344o
10.1126/science.289.5484.1508
10.1093/jn/130.7.1675
10.1016/S0006-2952(97)00402-4
10.1016/0006-291X(91)90490-X
10.1016/S0006-2952(99)00351-2
10.1021/jm00174a020
10.1126/science.289.5484.1498
10.1210/endo.140.9.7131
10.1056/NEJM199506153322401
10.1172/JCI115668
10.1210/jcem.86.3.7366
10.1126/science.1621100
10.1007/BF02180243
10.1016/S0006-2952(02)01585-X
10.1136/jcp.54.6.435
10.1093/jn/132.12.3577
10.1016/S8756-3282(01)00642-1
10.2741/2296
10.1210/endo.142.12.8533
10.1016/S8756-3282(01)00619-6
10.1126/science.289.5484.1497
10.1016/S0009-9120(97)00113-6
10.1002/1522-2675(20010815)84:8<2417::AID-HLCA2417>3.0.CO;2-N
10.1210/endo.138.11.5652
10.1073/pnas.85.7.2307
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Keywords Isoflavone
Osteogenic
Benzopyran
Antiosteoporotic
Estrogen
IPRIFLAVONE
MECHANISMS
GENISTEIN
BONE-RESORPTION
BREAST-CANCER
ISOFLAVONES
POSTMENOPAUSAL OSTEOPOROSIS
EQUOL
DAIDZEIN
ESTROGEN-RECEPTOR-ALPHA
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References Hofbauer, Khosla, Dunstan, Lacey, Spelsberg, Riggs (bib15) 2013; 140
Strong, Ohlstein, Jiang, Zhang, Zheng, Boue, Elliott, Gimble, Burow, Wang, Bunnell (bib43) 2014; 5
Joshua Allan, Damodaran, Deshmukh, Goudar, Amit (bib55) 2007; 45
Mazziotti, Bilezikian, Canalis, Cocchi, Giustina (bib8) 2012; 41
Parikka, Lehenkari, Sassi, Halleen, Risteli, Härkönen, Väänänen (bib18) 2001; 142
Sánchez-Duffhues, Hiepen, Knaus, ten Dijke (bib46) 2015; 80
Kiberstis, Smith, Norman (bib4) 2000
Pittas, Harris, Eliades, Stark, Dawson-Hughes (bib50) 2009; 94
Ray, Grover, Kamboj, Setty, Kar, Anand (bib44) 1976; 19
John Martin, Sims (bib26) 2005; 11
Ishimi (bib2) 2015; 61
Strong, Jiang, Zhang, Zheng, Boue, Elliott, Burow, Bunnell, Wang (bib42) 2014; 5
Yadav, Gautam, Kureel, Srivastava, Sahai, Singh, Chattopadhyay, Maurya (bib39) 2011; 21
Brzozowski, Pike, Walton, Hubbard, Thorsell, Li, Gustafsson, Carlquist (bib54) 2001; 9
Saika, Inoue, Kido, Matsumoto (bib16) 2001; 142
Cauley (bib21) 2015; 99
Jilka, Hangoc, Girasole, Passeri, Williams, Abrams, Boyce, Broxmeyer, Manolagas, Girasole, Jilka, Passeri, Boswell, Boder, Williams, Manolagas (bib17) 1992; 257
Sugimoto, Yamaguchi, Jia, Wang, Xie, Wang, Zhang, Picherit, Coxam, Bennetau-Pelissero, Kati-Coulibaly, Davicco, Lebecque, Barlet (bib33) 2000; 59
Arts, Kuiper, Janssen, Gustafsson, Lӧwik, Pols, Van- Leeuwen (bib51) 1997; 138
Yamaguchi, Gao, Wang, Jiang, Ye, Li, Tan (bib32) 1998; 55
Ernst, Schmid, Froesch (bib19) 1988; 85
Christenson (bib45) 1997; 30
Wozney, Rosen, Celeste, Mitsock, Whitters, Kriz, Hewick, Wang, Huang, Yang, Shao, Li (bib49) 1988; 242
Hussain, Ansari, Yadav, Gupta, Gupta, Saxena, Fatima, Manohar, Kushwaha, Khedgikar, Gautam, Kant, Maulik, Trivedi, Dwivedi, Kumar, Saxena, Hajela (bib40) 2014; 4
Muthyala, Ju, Sheng, Williams, Doerge, Katzenellenbogen, Helferich, Katzenellenbogen (bib52) 2004; 12
Khosla (bib14) 2013; 142
Colditz, Hankinson, Hunter, Willett, Manson, Stampfer, Hennekens, Rosner, Speizer (bib23) 1995; 332
Manolagas (bib9) 2000; 21
Bhargavan, Singh, Gautam, Mishra, Kumar, Goel, Dixit, Pandey, Manickavasagam, Dwivedi, Chakravarti, Jain, Ramachandran, Maurya, Trivedi, Chattopadhyay, Sanyal (bib37) 2012; 23
R. F. Service (bib5) 2000
Gupta, Ahmad, Kureel, Hasanain, Pandey, Singh, John, Sarkar, Singh, Agnusdei, Zacchei, Bigazzi, Cepollaro, Nardi, Montagnani, Gennari, Reginster, Kakai, Kawase, Nakano, Mikuni-Takagaki, Saito (bib38) 2016; 158
Parfitt (bib10) 2002; 30
Rosen, Bilezikian (bib30) 2013; 86
Appelman-Dijkstra, Papapoulos (bib25) 2015; 75
Clarke (bib6) 2008; 3
Lupsa, Insogna (bib3) 2015; 44
Srivastava, Tyagi, Khan, Dixit, Lahiri, Kumar, Changkija, Khan, Nagar, Yadav, Maurya, Singh, Jain, Wahajuddin, Trivedi, Chattopadhyay, Singh (bib34) 2013; 20
Huh, Lee, Kang, Nam, Choi, Park, Lee, Lee (bib35) 2014; 77
Takuwa, Ohse, Wang, Wozney, Yamashita (bib48) 1991; 174
Amari, Armani, Ghirardi, Delcanale, Civelli, Caruso, Galbiati, Lipreri, Rivara, Lodola, Mor, Sharma, Saeed, Durani, Kapil (bib53) 2004; 12
Tseng, Chen, Lu, Wang, Tsai, Lin, Chen, Chang, Wang, Ho, Tzeng (bib41) 2009; 44
Jin, Li, Wan (bib12) 2015; 29
Khosla, Oursler, Monroe (bib20) 2012; 23
Sato, Grese, Dodge, Bryant, Turner (bib24) 1999; 42
Burr (bib11) 2002; 30
Harvey, Dennison, Cooper (bib1) 2014; 29
Rodan, Martin (bib28) 2000
Delcanale, Amari, Armani, Lipreri, Civelli, Galbiati, Giossi, Caruso, Crivori, Carrupt, Testa (bib31) 2001; 84
Feeley, Wells (bib22) 2001; 54
Iniguez-Ariza, Clarke (bib7) 2015; 82
Nakashima, Hayashi, Takayanagi (bib27) 2012; 23
Ghosh (bib56) 1984
Chen, Zhao, Mundy (bib47) 2004; 22
Fujioka, Uehara, Wu, Adlercreutz, Suzuki, Kanazawa, Takeda, Yamada, Ishimi, Sehmisch, Uffenorde, Maehlmeyer, Tezval, Jarry, Stuermer, Stuermer, Setchell, Brown, Lydeking-Olsen (bib36) 2004; 134
Kearns, Khosla, Kostenuik (bib13) 2013; 29
Kanis, Svedbom, Harvey, McCloskey (bib29) 2014; 29
Jin, ZX (WOS:000353291200003) 2015; 29
REGINSTER, JYL (WOS:A1993MV52400006) 1993; 23
Sugimoto, E (WOS:000084899600003) 2000; 59
Fujioka, M (WOS:000224288300021) 2004; 134
Clarke, B (WOS:000260628500002) 2008; 3
Service, RF (WOS:000089071700034) 2000; 289
Rodan, GA (WOS:000089071700037) 2000; 289
Appelman-Dijkstra, NM (WOS:000358885700001) 2015; 75
Nakashima, T (WOS:000310420100006) 2012; 23
GIRASOLE, G (WOS:A1992HH51300022) 1992; 89
Yadav, DK (WOS:000285998000011) 2011; 21
Setchell, KDR (WOS:000179833000003) 2002; 132
Parikka, V (WOS:000172452700043) 2001; 142
Pittas, AG (WOS:000264020700019) 2009; 94
Burr, DB (WOS:000173536900001) 2002; 30
TAKUWA, Y (WOS:A1991ET20700016) 1991; 174
Jia, TL (WOS:000181432800002) 2003; 65
Parfitt, AM (WOS:000173536900002) 2002; 30
Muthyala, RS (WOS:000220237800032) 2004; 12
Strong, AL (WOS:000331493600009) 2014; 5
COLDITZ, GA (WOS:A1995RC19200001) 1995; 332
Hussain, MK (WOS:000330800300057) 2014; 4
Chen, D (WOS:000226752400004) 2004; 22
Saika, M (WOS:000168903100009) 2001; 142
Khosla, S (WOS:000310420100005) 2012; 23
Amari, G (WOS:000222572900001) 2004; 12
Tseng, CH (WOS:000268744700032) 2009; 44
Wang, SF (WOS:000230780600009) 2005; 13
Kearns, AE (WOS:000254641000002) 2008; 29
Allan, JJ (WOS:000249598500017) 2007; 45
Strong, AL (WOS:000344568300001) 2014; 5
RAY, S (WOS:A1976BD35600014) 1976; 19
Sato, M (WOS:000078198300001) 1999; 42
Delcanale, M (WOS:000171320300021) 2001; 84
Martin, TJ (WOS:000227323500006) 2005; 11
KAKAI, Y (WOS:A1992JX59000005) 1992; 51
Lupsa, BC (WOS:000361777000006) 2015; 44
Mazziotti, G (WOS:000298968700007) 2012; 41
Picherit, C (WOS:000088042200006) 2000; 130
Christenson, RH (WOS:000071563100001) 1997; 30
Manolagas, SC (WOS:000086493300001) 2000; 21
Khosla, S (WOS:000172452700002) 2001; 142
Srivastava, K (WOS:000319181900002) 2013; 20
SHARMA, AP (WOS:A1990EK45900020) 1990; 33
Hofbauer, LC (WOS:000082153200057) 1999; 140
Arts, J (WOS:A1997YB47900070) 1997; 138
WOZNEY, JM (WOS:A1988R365100029) 1988; 242
Feeley, KM (WOS:000169191500003) 2001; 54
Cauley, JA (WOS:000356984700003) 2015; 99
Sanchez-Duffhues, G (WOS:000362929000007) 2015; 80
Ishimi, Y (WOS:000355020700056) 2015; 61
Pike, ACW (WOS:000168050500008) 2001; 9
Iniguez-Ariza, NM (WOS:000362995100018) 2015; 82
AGNUSDEI, D (WOS:A1989AA72600008) 1989; 15
Bhargavan, B (WOS:000298443300004) 2012; 23
JILKA, RL (WOS:A1992JC16500036) 1992; 257
ERNST, M (WOS:A1988M910400062) 1988; 85
Rosen, C.J. (000382269700008.50) 2013; 86
Ghosh, M.N. (000382269700008.18) 1984
Huh, JE (WOS:000345472100014) 2014; 77
Kiberstis, P (WOS:000089071700033) 2000; 289
Gupta, A (WOS:000372690200008) 2016; 158
Harvey, N (WOS:000340846000001) 2014; 29
Yamaguchi, M (WOS:A1998YJ69900010) 1998; 55
Kanis, JA (WOS:000340846000002) 2014; 29
Huang, W (WOS:000246157900026) 2007; 12
Sehmisch, S (WOS:000278701100006) 2010; 17
Reginster (10.1016/j.ejmech.2016.05.023_bib38c) 1993; 23
Agnusdei (10.1016/j.ejmech.2016.05.023_bib38b) 1989; 15
Appelman-Dijkstra (10.1016/j.ejmech.2016.05.023_bib25) 2015; 75
John Martin (10.1016/j.ejmech.2016.05.023_bib26) 2005; 11
Lupsa (10.1016/j.ejmech.2016.05.023_bib3) 2015; 44
Jilka (10.1016/j.ejmech.2016.05.023_bib17a) 1992; 257
Jia (10.1016/j.ejmech.2016.05.023_bib33b) 2003; 65
Sehmisch (10.1016/j.ejmech.2016.05.023_bib36b) 2010; 17
Huang (10.1016/j.ejmech.2016.05.023_bib49b) 2007; 12
Saika (10.1016/j.ejmech.2016.05.023_bib16) 2001; 142
Chen (10.1016/j.ejmech.2016.05.023_bib47) 2004; 22
Parikka (10.1016/j.ejmech.2016.05.023_bib18) 2001; 142
Ishimi (10.1016/j.ejmech.2016.05.023_bib2) 2015; 61
Sato (10.1016/j.ejmech.2016.05.023_bib24) 1999; 42
Sugimoto (10.1016/j.ejmech.2016.05.023_bib33a) 2000; 59
Setchell (10.1016/j.ejmech.2016.05.023_bib36c) 2002; 132
Rodan (10.1016/j.ejmech.2016.05.023_bib28) 2000
Wang (10.1016/j.ejmech.2016.05.023_bibab) 2005; 13
Parfitt (10.1016/j.ejmech.2016.05.023_bib10) 2002; 30
Pittas (10.1016/j.ejmech.2016.05.023_bib50) 2009; 94
Wozney (10.1016/j.ejmech.2016.05.023_bib49a) 1988; 242
Girasole (10.1016/j.ejmech.2016.05.023_bib17b) 1992; 89
Strong (10.1016/j.ejmech.2016.05.023_bib42) 2014; 5
Huh (10.1016/j.ejmech.2016.05.023_bib35) 2014; 77
Ray (10.1016/j.ejmech.2016.05.023_bib44) 1976; 19
Amari (10.1016/j.ejmech.2016.05.023_bib53a) 2004; 12
R. F. Service (10.1016/j.ejmech.2016.05.023_bib5) 2000
Iniguez-Ariza (10.1016/j.ejmech.2016.05.023_bib7) 2015; 82
Tseng (10.1016/j.ejmech.2016.05.023_bib41) 2009; 44
Clarke (10.1016/j.ejmech.2016.05.023_bib6) 2008; 3
Fujioka (10.1016/j.ejmech.2016.05.023_bib36a) 2004; 134
Strong (10.1016/j.ejmech.2016.05.023_bib43) 2014; 5
Christenson (10.1016/j.ejmech.2016.05.023_bib45) 1997; 30
Sánchez-Duffhues (10.1016/j.ejmech.2016.05.023_bib46) 2015; 80
Cauley (10.1016/j.ejmech.2016.05.023_bib21) 2015; 99
Ernst (10.1016/j.ejmech.2016.05.023_bib19) 1988; 85
Ghosh (10.1016/j.ejmech.2016.05.023_bib56) 1984
Manolagas (10.1016/j.ejmech.2016.05.023_bib9) 2000; 21
Yamaguchi (10.1016/j.ejmech.2016.05.023_bib32a) 1998; 55
Picherit (10.1016/j.ejmech.2016.05.023_bib33c) 2000; 130
Hofbauer (10.1016/j.ejmech.2016.05.023_bib15) 2013; 140
Kakai (10.1016/j.ejmech.2016.05.023_bib38d) 1992; 51
Brzozowski (10.1016/j.ejmech.2016.05.023_bib54) 2001; 9
Joshua Allan (10.1016/j.ejmech.2016.05.023_bib55) 2007; 45
Kiberstis (10.1016/j.ejmech.2016.05.023_bib4) 2000
Arts (10.1016/j.ejmech.2016.05.023_bib51) 1997; 138
Harvey (10.1016/j.ejmech.2016.05.023_bib1) 2014; 29
Hussain (10.1016/j.ejmech.2016.05.023_bib40) 2014; 4
Muthyala (10.1016/j.ejmech.2016.05.023_bib52) 2004; 12
Jin (10.1016/j.ejmech.2016.05.023_bib12) 2015; 29
Kearns (10.1016/j.ejmech.2016.05.023_bib13) 2013; 29
Gupta (10.1016/j.ejmech.2016.05.023_bib38a) 2016; 158
Burr (10.1016/j.ejmech.2016.05.023_bib11) 2002; 30
Takuwa (10.1016/j.ejmech.2016.05.023_bib48) 1991; 174
Delcanale (10.1016/j.ejmech.2016.05.023_bib31) 2001; 84
Kanis (10.1016/j.ejmech.2016.05.023_bib29) 2014; 29
Feeley (10.1016/j.ejmech.2016.05.023_bib22) 2001; 54
Khosla (10.1016/j.ejmech.2016.05.023_bib14) 2013; 142
Rosen (10.1016/j.ejmech.2016.05.023_bib30) 2013; 86
Yadav (10.1016/j.ejmech.2016.05.023_bib39) 2011; 21
Khosla (10.1016/j.ejmech.2016.05.023_bib20) 2012; 23
Colditz (10.1016/j.ejmech.2016.05.023_bib23) 1995; 332
Bhargavan (10.1016/j.ejmech.2016.05.023_bib37) 2012; 23
Sharma (10.1016/j.ejmech.2016.05.023_bib53b) 1990; 33
Nakashima (10.1016/j.ejmech.2016.05.023_bib27) 2012; 23
Mazziotti (10.1016/j.ejmech.2016.05.023_bib8) 2012; 41
Srivastava (10.1016/j.ejmech.2016.05.023_bib34) 2013; 20
References_xml – volume: 140
  start-page: 4367
  year: 2013
  end-page: 4370
  ident: bib15
  article-title: Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells
  publication-title: Endocrinology
  contributor:
    fullname: Riggs
– volume: 11
  start-page: 76
  year: 2005
  end-page: 81
  ident: bib26
  article-title: Osteoclast-derived activity in the coupling of bone formation to resorption
  publication-title: Trends Mol. Med.
  contributor:
    fullname: Sims
– volume: 4
  start-page: 8828
  year: 2014
  end-page: 8845
  ident: bib40
  article-title: Design and synthesis of ERα/ERβ selective coumarin and chromene derivatives as potential anti-breast cancer and anti-osteoporotic agents
  publication-title: RSC Adv.
  contributor:
    fullname: Hajela
– volume: 257
  start-page: 88
  year: 1992
  end-page: 91
  ident: bib17
  article-title: Incereased osteoclast development after estrogen loss: mediation by interleukin-6
  publication-title: Science
  contributor:
    fullname: Manolagas
– volume: 85
  start-page: 2307
  year: 1988
  end-page: 2310
  ident: bib19
  article-title: Enhanced osteoblast proliferation and collagen gene expression by estradiol
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  contributor:
    fullname: Froesch
– volume: 75
  start-page: 1049
  year: 2015
  end-page: 1058
  ident: bib25
  article-title: Modulating bone resorption and bone formation in opposite directions in the treatment of postmenopausal osteoporosis
  publication-title: Drugs
  contributor:
    fullname: Papapoulos
– start-page: 1498
  year: 2000
  end-page: 1500
  ident: bib5
  article-title: Tissue engineers build new bone
  publication-title: Science
  contributor:
    fullname: R. F. Service
– volume: 61
  start-page: S139
  year: 2015
  end-page: S141
  ident: bib2
  article-title: Osteoporosis and lifestyle
  publication-title: J. Nutr. Sci. Vitaminol.
  contributor:
    fullname: Ishimi
– volume: 44
  start-page: 517
  year: 2015
  end-page: 530
  ident: bib3
  article-title: Bone health and osteoporosis
  publication-title: Endocrinol. Metab. Clin. North Am.
  contributor:
    fullname: Insogna
– volume: 23
  start-page: 27
  year: 2012
  end-page: 38
  ident: bib37
  article-title: Medicarpin, a legume phytoalexin, stimulates osteoblast differentiation and promotes peak bone mass achievement in rats: evidence for estrogen receptor β-mediated osteogenic action of medicarpin
  publication-title: J. Nutr. Biochem.
  contributor:
    fullname: Sanyal
– volume: 138
  start-page: 5067
  year: 1997
  end-page: 5070
  ident: bib51
  article-title: Differential epression of estrogen receptors α and β mRNA during differentiation of human osteoblast SV-HFO cells
  publication-title: Endocrinology
  contributor:
    fullname: Van- Leeuwen
– volume: 84
  start-page: 2417
  year: 2001
  end-page: 2429
  ident: bib31
  article-title: Novel basic isoflavones as inhibitors of bone resorption
  publication-title: Helv. Chim. Acta
  contributor:
    fullname: Testa
– volume: 29
  start-page: 172
  year: 2015
  end-page: 186
  ident: bib12
  article-title: Minireview: nuclear receptor regulation of osteoclast and bone remodeling
  publication-title: Mol. Endocrinol.
  contributor:
    fullname: Wan
– volume: 20
  start-page: 470
  year: 2013
  end-page: 480
  ident: bib34
  article-title: Isoformononetin, a methoxydaidzein present in medicinal plants, reverses bone loss in osteopenic rats and exerts bone anabolic action by preventing osteoblast apoptosis
  publication-title: Phytomedicine
  contributor:
    fullname: Singh
– volume: 21
  start-page: 115
  year: 2000
  end-page: 137
  ident: bib9
  article-title: Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis
  publication-title: Endocr. Rev.
  contributor:
    fullname: Manolagas
– volume: 54
  start-page: 435
  year: 2001
  end-page: 440
  ident: bib22
  article-title: Hormone replacement therapy and the endometrium
  publication-title: J. Clin. Pathol.
  contributor:
    fullname: Wells
– volume: 242
  start-page: 1528
  year: 1988
  end-page: 1534
  ident: bib49
  article-title: Novel regulators of bone formation: molecular clones and activities
  publication-title: Science
  contributor:
    fullname: Li
– volume: 55
  start-page: 71
  year: 1998
  end-page: 76
  ident: bib32
  article-title: Inhibitory effect of genistein on bone resorption in tissue culture
  publication-title: Biochem. Pharmacol.
  contributor:
    fullname: Tan
– volume: 142
  start-page: 5050
  year: 2013
  end-page: 5055
  ident: bib14
  article-title: The OPG/RANKL/RANK system
  publication-title: Endocrinology
  contributor:
    fullname: Khosla
– volume: 82
  start-page: 245
  year: 2015
  end-page: 255
  ident: bib7
  article-title: Bone biology, signaling pathways, and therapeutic targets for osteoporosis
  publication-title: Maturitas
  contributor:
    fullname: Clarke
– volume: 99
  start-page: 11
  year: 2015
  end-page: 15
  ident: bib21
  article-title: Estrogen and bone health in men and women
  publication-title: Steroids
  contributor:
    fullname: Cauley
– volume: 332
  start-page: 1589
  year: 1995
  end-page: 1593
  ident: bib23
  article-title: The use of estrogens and progestins and the risk of breast cancer in postmenopausal women, N
  publication-title: Engl. J. Med.
  contributor:
    fullname: Speizer
– volume: 45
  start-page: 1928
  year: 2007
  end-page: 1937
  ident: bib55
  article-title: Safety evaluation of a standardized phytochemical composition extracted from Bacopa monnieri in sprague-dawley rats
  publication-title: Food Chem. Toxicol.
  contributor:
    fullname: Amit
– start-page: 1497
  year: 2000
  ident: bib4
  article-title: Bone health in the balance
  publication-title: Science
  contributor:
    fullname: Norman
– volume: 59
  start-page: 471
  year: 2000
  end-page: 475
  ident: bib33
  article-title: Stimulatory effect of daidzein in osteobalstic MC3T3-E1 cells
  publication-title: Biochem. Pharmacol.
  contributor:
    fullname: Barlet
– volume: 134
  start-page: 2623
  year: 2004
  end-page: 2627
  ident: bib36
  article-title: Equol, a metabolite of daidzein, inhibits bone loss in ovariectomized Mice
  publication-title: J. Nutr.
  contributor:
    fullname: Lydeking-Olsen
– volume: 5
  start-page: 105
  year: 2014
  end-page: 122
  ident: bib43
  article-title: Novel daidzein analogs enhance osteogenic activity of bone marrow-derived mesenchymal stem cells and adipose-derived stromal/stem cells through estrogen receptor dependent and independent mechanisms
  publication-title: Stem Cell Res. Ther.
  contributor:
    fullname: Bunnell
– volume: 29
  start-page: 1926
  year: 2014
  end-page: 1928
  ident: bib29
  article-title: The osteoporosis treatment gap
  publication-title: J. Bone. Min. Res.
  contributor:
    fullname: McCloskey
– volume: 29
  start-page: 1917
  year: 2014
  end-page: 1925
  ident: bib1
  article-title: A lifecourse approach
  publication-title: J. Bone. Min. Res.
  contributor:
    fullname: Cooper
– volume: 142
  start-page: 2205
  year: 2001
  end-page: 2212
  ident: bib16
  article-title: 17β-Estradiol stimulates expression of osteoprotegerin by a mouse stromal cell line, ST-2, via estrogen receptor-α
  publication-title: Endocrinology
  contributor:
    fullname: Matsumoto
– volume: 80
  start-page: 43
  year: 2015
  end-page: 59
  ident: bib46
  article-title: Bone morphogenetic protein signaling in bone homeostasis
  publication-title: Bone
  contributor:
    fullname: ten Dijke
– volume: 77
  start-page: 2423
  year: 2014
  end-page: 2431
  ident: bib35
  article-title: Formononetin attenuates osteoclastogenesis via suppressing the RANKEL-induced activation of NFκB
  publication-title: J. Nat. Prod.
  contributor:
    fullname: Lee
– volume: 30
  start-page: 2
  year: 2002
  end-page: 4
  ident: bib11
  article-title: Targeted and nontargeted remodeling
  publication-title: Bone
  contributor:
    fullname: Burr
– volume: 12
  start-page: 3763
  year: 2004
  end-page: 3782
  ident: bib53
  article-title: Synthesis, pharmacological evaluation, and structure–activity relationships of benzopyran derivatives with potent SERM activity
  publication-title: Bioorg. Med. Chem.
  contributor:
    fullname: Kapil
– volume: 12
  start-page: 1559
  year: 2004
  end-page: 1567
  ident: bib52
  article-title: Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta
  publication-title: Bioorg. Med. Chem.
  contributor:
    fullname: Katzenellenbogen
– volume: 158
  start-page: 63
  year: 2016
  end-page: 75
  ident: bib38
  article-title: Induction of targeted osteogenesis with 3-aryl-
  publication-title: J. Steroid Biochem. Mol. Biol.
  contributor:
    fullname: Saito
– volume: 42
  start-page: 1
  year: 1999
  end-page: 24
  ident: bib24
  article-title: Emerging therapies for the prevention or treatment of postmenopausal osteoporosis
  publication-title: J. Med. Chem.
  contributor:
    fullname: Turner
– volume: 9
  start-page: 145
  year: 2001
  end-page: 153
  ident: bib54
  article-title: Structural insights into the mode of action of a pure antiestrogen
  publication-title: Structure
  contributor:
    fullname: Carlquist
– volume: 94
  start-page: 827
  year: 2009
  end-page: 832
  ident: bib50
  article-title: Association between serum osteocalcin and markers of metabolic phenotype
  publication-title: J. Clin. Endocrinol. Metab.
  contributor:
    fullname: Dawson-Hughes
– volume: 86
  start-page: 957
  year: 2013
  end-page: 964
  ident: bib30
  article-title: Anabolic therapy for osteoporosis
  publication-title: J. Clin. Endocrinol. Metab.
  contributor:
    fullname: Bilezikian
– volume: 29
  start-page: 155
  year: 2013
  end-page: 192
  ident: bib13
  article-title: Receptor activator of nuclear factor κB ligand and osteoprotegerin regulation of bone remodeling in health and disease
  publication-title: Endocr. Rev.
  contributor:
    fullname: Kostenuik
– volume: 44
  start-page: 3621
  year: 2009
  end-page: 3626
  ident: bib41
  article-title: Synthesis and anti-osteoporotic evaluation of certain 3-amino-2-hydroxypropoxyisoflavone derivatives
  publication-title: Eur. J. Med. Chem.
  contributor:
    fullname: Tzeng
– volume: 19
  start-page: 276
  year: 1976
  end-page: 279
  ident: bib44
  article-title: Antifertility agents. 12. Structure-activity relationship of 3,4-diphenylchromenes and -chromans
  publication-title: J. Med. Chem.
  contributor:
    fullname: Anand
– volume: 22
  start-page: 233
  year: 2004
  end-page: 241
  ident: bib47
  article-title: Bone morphogenetic proteins
  publication-title: Growth Factors
  contributor:
    fullname: Mundy
– volume: 3
  start-page: S131
  year: 2008
  end-page: S139
  ident: bib6
  article-title: Normal bone anatomy and physiology
  publication-title: Clin. J. Am. Soc. Nephrol.
  contributor:
    fullname: Clarke
– volume: 142
  start-page: 5371
  year: 2001
  end-page: 5378
  ident: bib18
  article-title: Estrogen reduces the depth of resorption pits by disturbing the organic bone matrix degradation activity of mature osteoclasts
  publication-title: Endocrinology
  contributor:
    fullname: Väänänen
– volume: 21
  start-page: 677
  year: 2011
  end-page: 681
  ident: bib39
  article-title: Synthetic analogs of daidzein, having more potent osteoblast stimulating effect
  publication-title: Bioorg. Med. Chem. Lett.
  contributor:
    fullname: Maurya
– volume: 23
  start-page: 582
  year: 2012
  end-page: 590
  ident: bib27
  article-title: New insights into osteoclastogenic signaling mechanisms
  publication-title: Trends Mol. Med.
  contributor:
    fullname: Takayanagi
– start-page: 1508
  year: 2000
  end-page: 1514
  ident: bib28
  article-title: Therapeutic approaches to bone diseases
  publication-title: Science
  contributor:
    fullname: Martin
– volume: 30
  start-page: 5
  year: 2002
  end-page: 7
  ident: bib10
  article-title: Targeted and nontargeted bone remodeling: relationship to basic multicellular unit origination and progression
  publication-title: Bone
  contributor:
    fullname: Parfitt
– volume: 41
  start-page: 58
  year: 2012
  end-page: 69
  ident: bib8
  article-title: New understanding and treatments for osteoporosis
  publication-title: Endocrine
  contributor:
    fullname: Giustina
– start-page: 156
  year: 1984
  end-page: 157
  ident: bib56
  article-title: Fundamental of Experimental Pharmacology
  contributor:
    fullname: Ghosh
– volume: 23
  start-page: 576
  year: 2012
  end-page: 581
  ident: bib20
  article-title: Estrogen and the skeleton
  publication-title: Trends Endocr. Metab.
  contributor:
    fullname: Monroe
– volume: 5
  start-page: 143
  year: 2014
  end-page: 148
  ident: bib42
  article-title: Design, synthesis, and osteogenic activity of daidzein analogs on human mesenchymal stem cells
  publication-title: ACS Med. Chem. Lett.
  contributor:
    fullname: Wang
– volume: 30
  start-page: 573
  year: 1997
  end-page: 593
  ident: bib45
  article-title: Biochemical markers of bone metabolism: an overview
  publication-title: Clin. Biochem.
  contributor:
    fullname: Christenson
– volume: 174
  start-page: 96
  year: 1991
  end-page: 101
  ident: bib48
  article-title: Bone morphogenetic protein-2 stimulates alkaline phosphatase activity and collagen synthesis in cultured osteoblastic cells, MC3T3-E1
  publication-title: Biochem. Biophys. Res. Comm.
  contributor:
    fullname: Yamashita
– volume: 5
  start-page: 143
  year: 2014
  ident: WOS:000331493600009
  article-title: Design, Synthesis, and Osteogenic Activity of Daidzein Analogs on Human Mesenchymal Stem Cells
  publication-title: ACS MEDICINAL CHEMISTRY LETTERS
  doi: 10.1021/ml400397k
  contributor:
    fullname: Strong, AL
– volume: 4
  start-page: 8828
  year: 2014
  ident: WOS:000330800300057
  article-title: Design and synthesis of ER alpha/ER beta selective coumarin and chromene derivatives as potential anti-breast cancer and anti-osteoporotic agents
  publication-title: RSC ADVANCES
  doi: 10.1039/c3ra45749d
  contributor:
    fullname: Hussain, MK
– volume: 45
  start-page: 1928
  year: 2007
  ident: WOS:000249598500017
  article-title: Safety evaluation of a standardized phytochemical composition extracted from Bacopa monnieri in Sprague-Dawley rats
  publication-title: FOOD AND CHEMICAL TOXICOLOGY
  doi: 10.1016/j.fct.2007.04.010
  contributor:
    fullname: Allan, JJ
– volume: 65
  start-page: 709
  year: 2003
  ident: WOS:000181432800002
  article-title: Daidzein enhances osteoblast growth that may be mediated by increased bone morphogenetic protein (BMP) production
  publication-title: BIOCHEMICAL PHARMACOLOGY
  contributor:
    fullname: Jia, TL
– volume: 84
  start-page: 2417
  year: 2001
  ident: WOS:000171320300021
  article-title: Novel basic isoflavones as inhibitors of bone resorption
  publication-title: HELVETICA CHIMICA ACTA
  contributor:
    fullname: Delcanale, M
– volume: 51
  start-page: S11
  year: 1992
  ident: WOS:A1992JX59000005
  article-title: EFFECT OF IPRIFLAVONE AND ESTROGEN ON THE DIFFERENTIATION AND PROLIFERATION OF OSTEOGENIC CELLS
  publication-title: CALCIFIED TISSUE INTERNATIONAL
  contributor:
    fullname: KAKAI, Y
– volume: 82
  start-page: 245
  year: 2015
  ident: WOS:000362995100018
  article-title: Bone biology, signaling pathways, and therapeutic targets for osteoporosis
  publication-title: MATURITAS
  doi: 10.1016/j.maturitas.2015.07.003
  contributor:
    fullname: Iniguez-Ariza, NM
– volume: 22
  start-page: 233
  year: 2004
  ident: WOS:000226752400004
  article-title: Bone morphogenetic proteins
  publication-title: GROWTH FACTORS
  doi: 10.1080/08977190412331279890
  contributor:
    fullname: Chen, D
– volume: 174
  start-page: 96
  year: 1991
  ident: WOS:A1991ET20700016
  article-title: BONE MORPHOGENETIC PROTEIN-2 STIMULATES ALKALINE-PHOSPHATASE ACTIVITY AND COLLAGEN-SYNTHESIS IN CULTURED OSTEOBLASTIC CELLS, MC3T3-E1
  publication-title: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
  contributor:
    fullname: TAKUWA, Y
– volume: 13
  start-page: 4880
  year: 2005
  ident: WOS:000230780600009
  article-title: Genistein derivatives as selective estrogen receptor modulators: Sonochemical synthesis and in vivo anti-osteoporotic action
  publication-title: BIOORGANIC & MEDICINAL CHEMISTRY
  doi: 10.1016/j.bmc.2005.04.082
  contributor:
    fullname: Wang, SF
– volume: 23
  start-page: 576
  year: 2012
  ident: WOS:000310420100005
  article-title: Estrogen and the skeleton
  publication-title: TRENDS IN ENDOCRINOLOGY AND METABOLISM
  doi: 10.1016/j.tem.2012.03.008
  contributor:
    fullname: Khosla, S
– volume: 9
  start-page: 145
  year: 2001
  ident: WOS:000168050500008
  article-title: Structural insights into the mode of action of a pure antiestrogen
  publication-title: STRUCTURE
  contributor:
    fullname: Pike, ACW
– volume: 85
  start-page: 2307
  year: 1988
  ident: WOS:A1988M910400062
  article-title: ENHANCED OSTEOBLAST PROLIFERATION AND COLLAGEN GENE-EXPRESSION BY ESTRADIOL
  publication-title: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
  contributor:
    fullname: ERNST, M
– volume: 54
  start-page: 435
  year: 2001
  ident: WOS:000169191500003
  article-title: Hormone replacement therapy and the endometrium
  publication-title: JOURNAL OF CLINICAL PATHOLOGY
  contributor:
    fullname: Feeley, KM
– volume: 138
  start-page: 5067
  year: 1997
  ident: WOS:A1997YB47900070
  article-title: Differential expression of estrogen receptors alpha and beta mRNA during differentiation of human osteoblast SV-HFO cells
  publication-title: ENDOCRINOLOGY
  contributor:
    fullname: Arts, J
– volume: 12
  start-page: 1559
  year: 2004
  ident: WOS:000220237800032
  article-title: Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta
  publication-title: BIOORGANIC & MEDICINAL CHEMISTRY
  doi: 10.1016/j.bmc.2003.11.035
  contributor:
    fullname: Muthyala, RS
– volume: 86
  start-page: 957
  year: 2013
  ident: 000382269700008.50
  article-title: Anabolic therapy for osteoporosis
  publication-title: J. Clin. Endocrinol. Metab.
  contributor:
    fullname: Rosen, C.J.
– volume: 12
  start-page: 3763
  year: 2004
  ident: WOS:000222572900001
  article-title: Synthesis, pharmacological evaluation, and structure-activity relationships of benzopyran derivatives with potent SERM activity
  publication-title: BIOORGANIC & MEDICINAL CHEMISTRY
  doi: 10.1016/j.bmc.2004.05.015
  contributor:
    fullname: Amari, G
– volume: 23
  start-page: 223
  year: 1993
  ident: WOS:A1993MV52400006
  article-title: IPRIFLAVONE - PHARMACOLOGICAL PROPERTIES AND USEFULNESS IN POSTMENOPAUSAL OSTEOPOROSIS
  publication-title: BONE AND MINERAL
  contributor:
    fullname: REGINSTER, JYL
– volume: 3
  start-page: S131
  year: 2008
  ident: WOS:000260628500002
  article-title: Normal Bone Anatomy and Physiology
  publication-title: CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
  doi: 10.2215/CJN.04151206
  contributor:
    fullname: Clarke, B
– volume: 41
  start-page: 58
  year: 2012
  ident: WOS:000298968700007
  article-title: New understanding and treatments for osteoporosis
  publication-title: ENDOCRINE
  doi: 10.1007/s12020-011-9570-2
  contributor:
    fullname: Mazziotti, G
– volume: 132
  start-page: 3577
  year: 2002
  ident: WOS:000179833000003
  article-title: The clinical importance of the metabolite equol - A clue to the effectiveness of soy and its isoflavones
  publication-title: JOURNAL OF NUTRITION
  contributor:
    fullname: Setchell, KDR
– volume: 289
  start-page: 1508
  year: 2000
  ident: WOS:000089071700037
  article-title: Therapeutic approaches to bone diseases
  publication-title: SCIENCE
  contributor:
    fullname: Rodan, GA
– volume: 5
  start-page: ARTN 105
  year: 2014
  ident: WOS:000344568300001
  article-title: Novel daidzein analogs enhance osteogenic activity of bone marrow-derived mesenchymal stem cells and adipose-derived stromal/stem cells through estrogen receptor dependent and independent mechanisms
  publication-title: STEM CELL RESEARCH & THERAPY
  doi: 10.1186/scrt493
  contributor:
    fullname: Strong, AL
– start-page: 156
  year: 1984
  ident: 000382269700008.18
  publication-title: Fundamental of Experimental Pharmacology
  contributor:
    fullname: Ghosh, M.N.
– volume: 29
  start-page: 172
  year: 2015
  ident: WOS:000353291200003
  article-title: Minireview: Nuclear Receptor Regulation of Osteoclast and Bone Remodeling
  publication-title: MOLECULAR ENDOCRINOLOGY
  doi: 10.1210/me.2014-1316
  contributor:
    fullname: Jin, ZX
– volume: 134
  start-page: 2623
  year: 2004
  ident: WOS:000224288300021
  article-title: Equol, a metabolite of daidzein, inhibits bone loss in ovariectomized mice
  publication-title: JOURNAL OF NUTRITION
  contributor:
    fullname: Fujioka, M
– volume: 257
  start-page: 88
  year: 1992
  ident: WOS:A1992JC16500036
  article-title: INCREASED OSTEOCLAST DEVELOPMENT AFTER ESTROGEN LOSS - MEDIATION BY INTERLEUKIN-6
  publication-title: SCIENCE
  contributor:
    fullname: JILKA, RL
– volume: 142
  start-page: 2205
  year: 2001
  ident: WOS:000168903100009
  article-title: 17 beta-estradiol stimulates expression of osteoprotegerin by a mouse stromal cell line, ST-2, via estrogen receptor-alpha
  publication-title: ENDOCRINOLOGY
  contributor:
    fullname: Saika, M
– volume: 289
  start-page: 1497
  year: 2000
  ident: WOS:000089071700033
  article-title: Bone health in the balance
  publication-title: SCIENCE
  contributor:
    fullname: Kiberstis, P
– volume: 44
  start-page: 3621
  year: 2009
  ident: WOS:000268744700032
  article-title: Synthesis and anti-osteoporotic evaluation of certain 3-amino-2-hydroxypropoxyisoflavone derivatives
  publication-title: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
  doi: 10.1016/j.ejmech.2009.02.025
  contributor:
    fullname: Tseng, CH
– volume: 15
  start-page: 97
  year: 1989
  ident: WOS:A1989AA72600008
  article-title: METABOLIC AND CLINICAL EFFECTS OF IPRIFLAVONE IN ESTABLISHED POST-MENOPAUSAL OSTEOPOROSIS
  publication-title: DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH
  contributor:
    fullname: AGNUSDEI, D
– volume: 55
  start-page: 71
  year: 1998
  ident: WOS:A1998YJ69900010
  article-title: Inhibitory effect of genistein on bone resorption in tissue culture
  publication-title: BIOCHEMICAL PHARMACOLOGY
  contributor:
    fullname: Yamaguchi, M
– volume: 130
  start-page: 1675
  year: 2000
  ident: WOS:000088042200006
  article-title: Daidzein is more efficient than genistein in preventing ovariectomy-induced bone loss in rats
  publication-title: JOURNAL OF NUTRITION
  contributor:
    fullname: Picherit, C
– volume: 142
  start-page: 5050
  year: 2001
  ident: WOS:000172452700002
  article-title: Minireview: The OPG/RANKL/RANK system
  publication-title: ENDOCRINOLOGY
  contributor:
    fullname: Khosla, S
– volume: 23
  start-page: 582
  year: 2012
  ident: WOS:000310420100006
  article-title: New insights into osteoclastogenic signaling mechanisms
  publication-title: TRENDS IN ENDOCRINOLOGY AND METABOLISM
  doi: 10.1016/j.tem.2012.05.005
  contributor:
    fullname: Nakashima, T
– volume: 289
  start-page: 1498
  year: 2000
  ident: WOS:000089071700034
  article-title: Tissue engineers build new bone
  publication-title: SCIENCE
  contributor:
    fullname: Service, RF
– volume: 59
  start-page: 471
  year: 2000
  ident: WOS:000084899600003
  article-title: Stimulatory effect of daidzein in osteoblastic MC3T3-E1 cells
  publication-title: BIOCHEMICAL PHARMACOLOGY
  contributor:
    fullname: Sugimoto, E
– volume: 30
  start-page: 573
  year: 1997
  ident: WOS:000071563100001
  article-title: Biochemical markers of bone metabolism: An overview
  publication-title: CLINICAL BIOCHEMISTRY
  contributor:
    fullname: Christenson, RH
– volume: 89
  start-page: 883
  year: 1992
  ident: WOS:A1992HH51300022
  article-title: 17-BETA-ESTRADIOL INHIBITS INTERLEUKIN-6 PRODUCTION BY BONE MARROW-DERIVED STROMAL CELLS AND OSTEOBLASTS INVITRO - A POTENTIAL MECHANISM FOR THE ANTIOSTEOPOROTIC EFFECT OF ESTROGENS
  publication-title: JOURNAL OF CLINICAL INVESTIGATION
  contributor:
    fullname: GIRASOLE, G
– volume: 158
  start-page: 63
  year: 2016
  ident: WOS:000372690200008
  article-title: Induction of targeted osteogenesis with 3-aryl-2H-benzopyrans and 3-aryl-3H-benzopyrans: Novel osteogenic
  publication-title: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
  doi: 10.1016/j.jsbmb.2016.01.010
  contributor:
    fullname: Gupta, A
– volume: 94
  start-page: 827
  year: 2009
  ident: WOS:000264020700019
  article-title: Association between Serum Osteocalcin and Markers of Metabolic Phenotype
  publication-title: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
  doi: 10.1210/jc.2008-1422
  contributor:
    fullname: Pittas, AG
– volume: 11
  start-page: 76
  year: 2005
  ident: WOS:000227323500006
  article-title: Osteoclast-derived activity in the coupling of bone formation to resorption
  publication-title: TRENDS IN MOLECULAR MEDICINE
  doi: 10.1016/j.molmed.2004.12.004
  contributor:
    fullname: Martin, TJ
– volume: 33
  start-page: 3222
  year: 1990
  ident: WOS:A1990EK45900020
  article-title: STRUCTURE ACTIVITY RELATIONSHIP OF ANTIESTROGENS - PHENOLIC ANALOGS OF 2,3-DIARYL-2H-1-BENZOPYRANS
  publication-title: JOURNAL OF MEDICINAL CHEMISTRY
  contributor:
    fullname: SHARMA, AP
– volume: 140
  start-page: 4367
  year: 1999
  ident: WOS:000082153200057
  article-title: Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells
  publication-title: ENDOCRINOLOGY
  contributor:
    fullname: Hofbauer, LC
– volume: 42
  start-page: 1
  year: 1999
  ident: WOS:000078198300001
  article-title: Emerging therapies for the prevention or treatment of postmenopausal osteoporosis
  publication-title: JOURNAL OF MEDICINAL CHEMISTRY
  contributor:
    fullname: Sato, M
– volume: 242
  start-page: 1528
  year: 1988
  ident: WOS:A1988R365100029
  article-title: NOVEL REGULATORS OF BONE-FORMATION - MOLECULAR CLONES AND ACTIVITIES
  publication-title: SCIENCE
  contributor:
    fullname: WOZNEY, JM
– volume: 29
  start-page: 1917
  year: 2014
  ident: WOS:000340846000001
  article-title: Osteoporosis: A Lifecourse Approach
  publication-title: JOURNAL OF BONE AND MINERAL RESEARCH
  doi: 10.1002/jbmr.2286
  contributor:
    fullname: Harvey, N
– volume: 44
  start-page: 517
  year: 2015
  ident: WOS:000361777000006
  article-title: Bone Health and Osteoporosis
  publication-title: ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
  doi: 10.1016/j.ecl.2015.05.002
  contributor:
    fullname: Lupsa, BC
– volume: 20
  start-page: 470
  year: 2013
  ident: WOS:000319181900002
  article-title: Isoformononetin, a methoxydaidzein present in medicinal plants, reverses bone loss in osteopenic rats and exerts bone anabolic action by preventing osteoblast apoptosis
  publication-title: PHYTOMEDICINE
  doi: 10.1016/j.phymed.2012.12.021
  contributor:
    fullname: Srivastava, K
– volume: 21
  start-page: 677
  year: 2011
  ident: WOS:000285998000011
  article-title: Synthetic analogs of daidzein, having more potent osteoblast stimulating effect
  publication-title: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  doi: 10.1016/j.bmcl.2010.12.008
  contributor:
    fullname: Yadav, DK
– volume: 80
  start-page: 43
  year: 2015
  ident: WOS:000362929000007
  article-title: Bone morphogenetic protein signaling in bone homeostasis
  publication-title: BONE
  doi: 10.1016/j.bone.2015.05.025
  contributor:
    fullname: Sanchez-Duffhues, G
– volume: 29
  start-page: 155
  year: 2008
  ident: WOS:000254641000002
  article-title: Receptor activator of nuclear factor kappa B ligand and osteoprotegerin regulation of bone remodeling in health and disease
  publication-title: ENDOCRINE REVIEWS
  doi: 10.1210/er.2007-0014
  contributor:
    fullname: Kearns, AE
– volume: 17
  start-page: 424
  year: 2010
  ident: WOS:000278701100006
  article-title: Evaluation of bone quality and quantity in osteoporotic mice - The effects of genistein and equol
  publication-title: PHYTOMEDICINE
  doi: 10.1016/j.phymed.2009.10.004
  contributor:
    fullname: Sehmisch, S
– volume: 332
  start-page: 1589
  year: 1995
  ident: WOS:A1995RC19200001
  article-title: THE USE OF ESTROGENS AND PROGESTINS AND THE RISK OF BREAST-CANCER IN POSTMENOPAUSAL WOMEN
  publication-title: NEW ENGLAND JOURNAL OF MEDICINE
  contributor:
    fullname: COLDITZ, GA
– volume: 29
  start-page: 1926
  year: 2014
  ident: WOS:000340846000002
  article-title: The Osteoporosis Treatment Gap
  publication-title: JOURNAL OF BONE AND MINERAL RESEARCH
  doi: 10.1002/jbmr.2301
  contributor:
    fullname: Kanis, JA
– volume: 30
  start-page: 2
  year: 2002
  ident: WOS:000173536900001
  article-title: Targeted and nontargeted remodeling
  publication-title: BONE
  contributor:
    fullname: Burr, DB
– volume: 19
  start-page: 276
  year: 1976
  ident: WOS:A1976BD35600014
  article-title: ANTIFERTILITY AGENTS .12. STRUCTURE-ACTIVITY RELATIONSHIP OF 3,4-DIPHENYLCHROMENES AND 3,4-DIPHENYLCHROMANS
  publication-title: JOURNAL OF MEDICINAL CHEMISTRY
  contributor:
    fullname: RAY, S
– volume: 99
  start-page: 11
  year: 2015
  ident: WOS:000356984700003
  article-title: Estrogen and bone health in men and women
  publication-title: STEROIDS
  doi: 10.1016/j.steroids.2014.12.010
  contributor:
    fullname: Cauley, JA
– volume: 21
  start-page: 115
  year: 2000
  ident: WOS:000086493300001
  article-title: Birth and death of bone cells: Basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis
  publication-title: ENDOCRINE REVIEWS
  contributor:
    fullname: Manolagas, SC
– volume: 23
  start-page: 27
  year: 2012
  ident: WOS:000298443300004
  article-title: Medicarpin, a legume phytoalexin, stimulates osteoblast differentiation and promotes peak bone mass achievement in rats: evidence for estrogen receptor beta-mediated osteogenic action of medicarpin
  publication-title: JOURNAL OF NUTRITIONAL BIOCHEMISTRY
  doi: 10.1016/j.jnutbio.2010.11.002
  contributor:
    fullname: Bhargavan, B
– volume: 75
  start-page: 1049
  year: 2015
  ident: WOS:000358885700001
  article-title: Modulating Bone Resorption and Bone Formation in Opposite Directions in the Treatment of Postmenopausal Osteoporosis
  publication-title: DRUGS
  doi: 10.1007/s40265-015-0417-7
  contributor:
    fullname: Appelman-Dijkstra, NM
– volume: 142
  start-page: 5371
  year: 2001
  ident: WOS:000172452700043
  article-title: Estrogen reduces the depth of resorption pits by disturbing the organic bone matrix degradation activity of mature osteoclasts
  publication-title: ENDOCRINOLOGY
  contributor:
    fullname: Parikka, V
– volume: 61
  start-page: S139
  year: 2015
  ident: WOS:000355020700056
  article-title: Osteoporosis and Lifestyle
  publication-title: JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
  contributor:
    fullname: Ishimi, Y
– volume: 30
  start-page: 5
  year: 2002
  ident: WOS:000173536900002
  article-title: Targeted and nontargeted bone remodeling: relationship to basic multicellular unit origination and progression
  publication-title: BONE
  contributor:
    fullname: Parfitt, AM
– volume: 77
  start-page: 2423
  year: 2014
  ident: WOS:000345472100014
  article-title: Formononetin Attenuates Osteoclastogenesis via Suppressing the RANKL-Induced Activation of NF-f kappa B, c-Fos, and Nuclear Factor of Activated T-Cells Cytoplasmic 1 Signaling Pathway
  publication-title: JOURNAL OF NATURAL PRODUCTS
  doi: 10.1021/np500417d
  contributor:
    fullname: Huh, JE
– volume: 12
  start-page: 3068
  year: 2007
  ident: WOS:000246157900026
  article-title: Signaling and transcriptional regulation in osteoblast commitment and differentiation
  publication-title: FRONTIERS IN BIOSCIENCE-LANDMARK
  contributor:
    fullname: Huang, W
– volume: 23
  start-page: 27
  year: 2012
  ident: 10.1016/j.ejmech.2016.05.023_bib37
  article-title: Medicarpin, a legume phytoalexin, stimulates osteoblast differentiation and promotes peak bone mass achievement in rats: evidence for estrogen receptor β-mediated osteogenic action of medicarpin
  publication-title: J. Nutr. Biochem.
  doi: 10.1016/j.jnutbio.2010.11.002
  contributor:
    fullname: Bhargavan
– volume: 13
  start-page: 4880
  year: 2005
  ident: 10.1016/j.ejmech.2016.05.023_bibab
  article-title: Genistein derivatives as selective estrogen receptor modulators: sonochemical synthesis and in vivo anti-osteoporotic action
  publication-title: Bioorg. Med. Chem.
  doi: 10.1016/j.bmc.2005.04.082
  contributor:
    fullname: Wang
– volume: 142
  start-page: 2205
  year: 2001
  ident: 10.1016/j.ejmech.2016.05.023_bib16
  article-title: 17β-Estradiol stimulates expression of osteoprotegerin by a mouse stromal cell line, ST-2, via estrogen receptor-α
  publication-title: Endocrinology
  doi: 10.1210/endo.142.6.8220
  contributor:
    fullname: Saika
– volume: 41
  start-page: 58
  year: 2012
  ident: 10.1016/j.ejmech.2016.05.023_bib8
  article-title: New understanding and treatments for osteoporosis
  publication-title: Endocrine
  doi: 10.1007/s12020-011-9570-2
  contributor:
    fullname: Mazziotti
– volume: 4
  start-page: 8828
  year: 2014
  ident: 10.1016/j.ejmech.2016.05.023_bib40
  article-title: Design and synthesis of ERα/ERβ selective coumarin and chromene derivatives as potential anti-breast cancer and anti-osteoporotic agents
  publication-title: RSC Adv.
  doi: 10.1039/C3RA45749D
  contributor:
    fullname: Hussain
– volume: 20
  start-page: 470
  year: 2013
  ident: 10.1016/j.ejmech.2016.05.023_bib34
  article-title: Isoformononetin, a methoxydaidzein present in medicinal plants, reverses bone loss in osteopenic rats and exerts bone anabolic action by preventing osteoblast apoptosis
  publication-title: Phytomedicine
  doi: 10.1016/j.phymed.2012.12.021
  contributor:
    fullname: Srivastava
– volume: 80
  start-page: 43
  year: 2015
  ident: 10.1016/j.ejmech.2016.05.023_bib46
  article-title: Bone morphogenetic protein signaling in bone homeostasis
  publication-title: Bone
  doi: 10.1016/j.bone.2015.05.025
  contributor:
    fullname: Sánchez-Duffhues
– volume: 9
  start-page: 145
  year: 2001
  ident: 10.1016/j.ejmech.2016.05.023_bib54
  article-title: Structural insights into the mode of action of a pure antiestrogen
  publication-title: Structure
  doi: 10.1016/S0969-2126(01)00568-8
  contributor:
    fullname: Brzozowski
– volume: 19
  start-page: 276
  year: 1976
  ident: 10.1016/j.ejmech.2016.05.023_bib44
  article-title: Antifertility agents. 12. Structure-activity relationship of 3,4-diphenylchromenes and -chromans
  publication-title: J. Med. Chem.
  doi: 10.1021/jm00224a014
  contributor:
    fullname: Ray
– volume: 142
  start-page: 5050
  year: 2013
  ident: 10.1016/j.ejmech.2016.05.023_bib14
  article-title: The OPG/RANKL/RANK system
  publication-title: Endocrinology
  doi: 10.1210/endo.142.12.8536
  contributor:
    fullname: Khosla
– volume: 5
  start-page: 105
  year: 2014
  ident: 10.1016/j.ejmech.2016.05.023_bib43
  article-title: Novel daidzein analogs enhance osteogenic activity of bone marrow-derived mesenchymal stem cells and adipose-derived stromal/stem cells through estrogen receptor dependent and independent mechanisms
  publication-title: Stem Cell Res. Ther.
  doi: 10.1186/scrt493
  contributor:
    fullname: Strong
– volume: 12
  start-page: 1559
  year: 2004
  ident: 10.1016/j.ejmech.2016.05.023_bib52
  article-title: Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta
  publication-title: Bioorg. Med. Chem.
  doi: 10.1016/j.bmc.2003.11.035
  contributor:
    fullname: Muthyala
– volume: 61
  start-page: S139
  year: 2015
  ident: 10.1016/j.ejmech.2016.05.023_bib2
  article-title: Osteoporosis and lifestyle
  publication-title: J. Nutr. Sci. Vitaminol.
  doi: 10.3177/jnsv.61.S139
  contributor:
    fullname: Ishimi
– volume: 134
  start-page: 2623
  year: 2004
  ident: 10.1016/j.ejmech.2016.05.023_bib36a
  article-title: Equol, a metabolite of daidzein, inhibits bone loss in ovariectomized Mice
  publication-title: J. Nutr.
  doi: 10.1093/jn/134.10.2623
  contributor:
    fullname: Fujioka
– volume: 242
  start-page: 1528
  year: 1988
  ident: 10.1016/j.ejmech.2016.05.023_bib49a
  article-title: Novel regulators of bone formation: molecular clones and activities
  publication-title: Science
  doi: 10.1126/science.3201241
  contributor:
    fullname: Wozney
– volume: 11
  start-page: 76
  year: 2005
  ident: 10.1016/j.ejmech.2016.05.023_bib26
  article-title: Osteoclast-derived activity in the coupling of bone formation to resorption
  publication-title: Trends Mol. Med.
  doi: 10.1016/j.molmed.2004.12.004
  contributor:
    fullname: John Martin
– volume: 94
  start-page: 827
  year: 2009
  ident: 10.1016/j.ejmech.2016.05.023_bib50
  article-title: Association between serum osteocalcin and markers of metabolic phenotype
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jc.2008-1422
  contributor:
    fullname: Pittas
– volume: 158
  start-page: 63
  year: 2016
  ident: 10.1016/j.ejmech.2016.05.023_bib38a
  article-title: Induction of targeted osteogenesis with 3-aryl-2H-benzopyrans and 3-aryl-3H-benzopyrans: novel osteogenic agents
  publication-title: J. Steroid Biochem. Mol. Biol.
  doi: 10.1016/j.jsbmb.2016.01.010
  contributor:
    fullname: Gupta
– volume: 23
  start-page: 223
  year: 1993
  ident: 10.1016/j.ejmech.2016.05.023_bib38c
  article-title: Ipriflavone: pharmacological properties and usefulness in postmenopausal osteoporosis
  publication-title: Bone Min.
  doi: 10.1016/S0169-6009(08)80099-2
  contributor:
    fullname: Reginster
– volume: 44
  start-page: 3621
  year: 2009
  ident: 10.1016/j.ejmech.2016.05.023_bib41
  article-title: Synthesis and anti-osteoporotic evaluation of certain 3-amino-2-hydroxypropoxyisoflavone derivatives
  publication-title: Eur. J. Med. Chem.
  doi: 10.1016/j.ejmech.2009.02.025
  contributor:
    fullname: Tseng
– volume: 23
  start-page: 576
  year: 2012
  ident: 10.1016/j.ejmech.2016.05.023_bib20
  article-title: Estrogen and the skeleton
  publication-title: Trends Endocr. Metab.
  doi: 10.1016/j.tem.2012.03.008
  contributor:
    fullname: Khosla
– volume: 42
  start-page: 1
  year: 1999
  ident: 10.1016/j.ejmech.2016.05.023_bib24
  article-title: Emerging therapies for the prevention or treatment of postmenopausal osteoporosis
  publication-title: J. Med. Chem.
  doi: 10.1021/jm980344o
  contributor:
    fullname: Sato
– start-page: 1508
  year: 2000
  ident: 10.1016/j.ejmech.2016.05.023_bib28
  article-title: Therapeutic approaches to bone diseases
  publication-title: Science
  doi: 10.1126/science.289.5484.1508
  contributor:
    fullname: Rodan
– volume: 130
  start-page: 1675
  year: 2000
  ident: 10.1016/j.ejmech.2016.05.023_bib33c
  article-title: Daidzein is more efficient than genistein in preventing ovariectomy-induced bone loss in rats
  publication-title: J. Nutr.
  doi: 10.1093/jn/130.7.1675
  contributor:
    fullname: Picherit
– volume: 45
  start-page: 1928
  year: 2007
  ident: 10.1016/j.ejmech.2016.05.023_bib55
  article-title: Safety evaluation of a standardized phytochemical composition extracted from Bacopa monnieri in sprague-dawley rats
  publication-title: Food Chem. Toxicol.
  doi: 10.1016/j.fct.2007.04.010
  contributor:
    fullname: Joshua Allan
– volume: 55
  start-page: 71
  year: 1998
  ident: 10.1016/j.ejmech.2016.05.023_bib32a
  article-title: Inhibitory effect of genistein on bone resorption in tissue culture
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/S0006-2952(97)00402-4
  contributor:
    fullname: Yamaguchi
– volume: 174
  start-page: 96
  year: 1991
  ident: 10.1016/j.ejmech.2016.05.023_bib48
  article-title: Bone morphogenetic protein-2 stimulates alkaline phosphatase activity and collagen synthesis in cultured osteoblastic cells, MC3T3-E1
  publication-title: Biochem. Biophys. Res. Comm.
  doi: 10.1016/0006-291X(91)90490-X
  contributor:
    fullname: Takuwa
– volume: 59
  start-page: 471
  year: 2000
  ident: 10.1016/j.ejmech.2016.05.023_bib33a
  article-title: Stimulatory effect of daidzein in osteobalstic MC3T3-E1 cells
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/S0006-2952(99)00351-2
  contributor:
    fullname: Sugimoto
– volume: 33
  start-page: 3222
  year: 1990
  ident: 10.1016/j.ejmech.2016.05.023_bib53b
  article-title: Structure-activity relationship of antiestrogens. Phenolic analogs of 2,3-diaryl-2H-1-benzopyrans
  publication-title: J. Med. Chem.
  doi: 10.1021/jm00174a020
  contributor:
    fullname: Sharma
– volume: 44
  start-page: 517
  year: 2015
  ident: 10.1016/j.ejmech.2016.05.023_bib3
  article-title: Bone health and osteoporosis
  publication-title: Endocrinol. Metab. Clin. North Am.
  doi: 10.1016/j.ecl.2015.05.002
  contributor:
    fullname: Lupsa
– start-page: 156
  year: 1984
  ident: 10.1016/j.ejmech.2016.05.023_bib56
  contributor:
    fullname: Ghosh
– start-page: 1498
  year: 2000
  ident: 10.1016/j.ejmech.2016.05.023_bib5
  article-title: Tissue engineers build new bone
  publication-title: Science
  doi: 10.1126/science.289.5484.1498
  contributor:
    fullname: R. F. Service
– volume: 140
  start-page: 4367
  year: 2013
  ident: 10.1016/j.ejmech.2016.05.023_bib15
  article-title: Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells
  publication-title: Endocrinology
  doi: 10.1210/endo.140.9.7131
  contributor:
    fullname: Hofbauer
– volume: 332
  start-page: 1589
  year: 1995
  ident: 10.1016/j.ejmech.2016.05.023_bib23
  article-title: The use of estrogens and progestins and the risk of breast cancer in postmenopausal women, N
  publication-title: Engl. J. Med.
  doi: 10.1056/NEJM199506153322401
  contributor:
    fullname: Colditz
– volume: 89
  start-page: 883
  year: 1992
  ident: 10.1016/j.ejmech.2016.05.023_bib17b
  article-title: 17β-Estradiol inhibits interleukin-6 production by bone marrow derived stromal cells and osteoblasts in vitro: a potential mechanism for antiosteoporotic effect of etrogens
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI115668
  contributor:
    fullname: Girasole
– volume: 22
  start-page: 233
  year: 2004
  ident: 10.1016/j.ejmech.2016.05.023_bib47
  article-title: Bone morphogenetic proteins
  publication-title: Growth Factors
  doi: 10.1080/08977190412331279890
  contributor:
    fullname: Chen
– volume: 29
  start-page: 1926
  year: 2014
  ident: 10.1016/j.ejmech.2016.05.023_bib29
  article-title: The osteoporosis treatment gap
  publication-title: J. Bone. Min. Res.
  doi: 10.1002/jbmr.2301
  contributor:
    fullname: Kanis
– volume: 86
  start-page: 957
  year: 2013
  ident: 10.1016/j.ejmech.2016.05.023_bib30
  article-title: Anabolic therapy for osteoporosis
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jcem.86.3.7366
  contributor:
    fullname: Rosen
– volume: 257
  start-page: 88
  year: 1992
  ident: 10.1016/j.ejmech.2016.05.023_bib17a
  article-title: Incereased osteoclast development after estrogen loss: mediation by interleukin-6
  publication-title: Science
  doi: 10.1126/science.1621100
  contributor:
    fullname: Jilka
– volume: 51
  start-page: S11
  issue: suppl. 1
  year: 1992
  ident: 10.1016/j.ejmech.2016.05.023_bib38d
  article-title: Effect of ipriflavone and estrogen on the differentiation and proliferation of osteogenic cells
  publication-title: Calcify. Tissue Int.
  doi: 10.1007/BF02180243
  contributor:
    fullname: Kakai
– volume: 65
  start-page: 709
  year: 2003
  ident: 10.1016/j.ejmech.2016.05.023_bib33b
  article-title: Daidzien enhance osteoblast growth that may be mediated by increased bone morphogenetic protein (BMP) production
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/S0006-2952(02)01585-X
  contributor:
    fullname: Jia
– volume: 54
  start-page: 435
  year: 2001
  ident: 10.1016/j.ejmech.2016.05.023_bib22
  article-title: Hormone replacement therapy and the endometrium
  publication-title: J. Clin. Pathol.
  doi: 10.1136/jcp.54.6.435
  contributor:
    fullname: Feeley
– volume: 12
  start-page: 3763
  year: 2004
  ident: 10.1016/j.ejmech.2016.05.023_bib53a
  article-title: Synthesis, pharmacological evaluation, and structure–activity relationships of benzopyran derivatives with potent SERM activity
  publication-title: Bioorg. Med. Chem.
  doi: 10.1016/j.bmc.2004.05.015
  contributor:
    fullname: Amari
– volume: 132
  start-page: 3577
  year: 2002
  ident: 10.1016/j.ejmech.2016.05.023_bib36c
  article-title: The Clinical importance of the metabolite equol-A clue to the effectiveness of soy and its isoflavones
  publication-title: J. Nutr.
  doi: 10.1093/jn/132.12.3577
  contributor:
    fullname: Setchell
– volume: 30
  start-page: 5
  year: 2002
  ident: 10.1016/j.ejmech.2016.05.023_bib10
  article-title: Targeted and nontargeted bone remodeling: relationship to basic multicellular unit origination and progression
  publication-title: Bone
  doi: 10.1016/S8756-3282(01)00642-1
  contributor:
    fullname: Parfitt
– volume: 17
  start-page: 424
  year: 2010
  ident: 10.1016/j.ejmech.2016.05.023_bib36b
  article-title: Evaluation of bone quality and quantity in osteoporotic mice-The effects of genistein and equol
  publication-title: Phytomedicine
  doi: 10.1016/j.phymed.2009.10.004
  contributor:
    fullname: Sehmisch
– volume: 5
  start-page: 143
  year: 2014
  ident: 10.1016/j.ejmech.2016.05.023_bib42
  article-title: Design, synthesis, and osteogenic activity of daidzein analogs on human mesenchymal stem cells
  publication-title: ACS Med. Chem. Lett.
  doi: 10.1021/ml400397k
  contributor:
    fullname: Strong
– volume: 12
  start-page: 3068
  year: 2007
  ident: 10.1016/j.ejmech.2016.05.023_bib49b
  article-title: Signaling and transcriptional regulation in osteoblast commitment and differentiation
  publication-title: Front. Biosci. Landmark
  doi: 10.2741/2296
  contributor:
    fullname: Huang
– volume: 29
  start-page: 1917
  year: 2014
  ident: 10.1016/j.ejmech.2016.05.023_bib1
  article-title: A lifecourse approach
  publication-title: J. Bone. Min. Res.
  doi: 10.1002/jbmr.2286
  contributor:
    fullname: Harvey
– volume: 142
  start-page: 5371
  year: 2001
  ident: 10.1016/j.ejmech.2016.05.023_bib18
  article-title: Estrogen reduces the depth of resorption pits by disturbing the organic bone matrix degradation activity of mature osteoclasts
  publication-title: Endocrinology
  doi: 10.1210/endo.142.12.8533
  contributor:
    fullname: Parikka
– volume: 23
  start-page: 582
  year: 2012
  ident: 10.1016/j.ejmech.2016.05.023_bib27
  article-title: New insights into osteoclastogenic signaling mechanisms
  publication-title: Trends Mol. Med.
  contributor:
    fullname: Nakashima
– volume: 77
  start-page: 2423
  year: 2014
  ident: 10.1016/j.ejmech.2016.05.023_bib35
  article-title: Formononetin attenuates osteoclastogenesis via suppressing the RANKEL-induced activation of NFκB
  publication-title: J. Nat. Prod.
  doi: 10.1021/np500417d
  contributor:
    fullname: Huh
– volume: 30
  start-page: 2
  year: 2002
  ident: 10.1016/j.ejmech.2016.05.023_bib11
  article-title: Targeted and nontargeted remodeling
  publication-title: Bone
  doi: 10.1016/S8756-3282(01)00619-6
  contributor:
    fullname: Burr
– start-page: 1497
  year: 2000
  ident: 10.1016/j.ejmech.2016.05.023_bib4
  article-title: Bone health in the balance
  publication-title: Science
  doi: 10.1126/science.289.5484.1497
  contributor:
    fullname: Kiberstis
– volume: 82
  start-page: 245
  year: 2015
  ident: 10.1016/j.ejmech.2016.05.023_bib7
  article-title: Bone biology, signaling pathways, and therapeutic targets for osteoporosis
  publication-title: Maturitas
  doi: 10.1016/j.maturitas.2015.07.003
  contributor:
    fullname: Iniguez-Ariza
– volume: 21
  start-page: 677
  year: 2011
  ident: 10.1016/j.ejmech.2016.05.023_bib39
  article-title: Synthetic analogs of daidzein, having more potent osteoblast stimulating effect
  publication-title: Bioorg. Med. Chem. Lett.
  doi: 10.1016/j.bmcl.2010.12.008
  contributor:
    fullname: Yadav
– volume: 29
  start-page: 172
  year: 2015
  ident: 10.1016/j.ejmech.2016.05.023_bib12
  article-title: Minireview: nuclear receptor regulation of osteoclast and bone remodeling
  publication-title: Mol. Endocrinol.
  doi: 10.1210/me.2014-1316
  contributor:
    fullname: Jin
– volume: 75
  start-page: 1049
  year: 2015
  ident: 10.1016/j.ejmech.2016.05.023_bib25
  article-title: Modulating bone resorption and bone formation in opposite directions in the treatment of postmenopausal osteoporosis
  publication-title: Drugs
  doi: 10.1007/s40265-015-0417-7
  contributor:
    fullname: Appelman-Dijkstra
– volume: 30
  start-page: 573
  year: 1997
  ident: 10.1016/j.ejmech.2016.05.023_bib45
  article-title: Biochemical markers of bone metabolism: an overview
  publication-title: Clin. Biochem.
  doi: 10.1016/S0009-9120(97)00113-6
  contributor:
    fullname: Christenson
– volume: 84
  start-page: 2417
  year: 2001
  ident: 10.1016/j.ejmech.2016.05.023_bib31
  article-title: Novel basic isoflavones as inhibitors of bone resorption
  publication-title: Helv. Chim. Acta
  doi: 10.1002/1522-2675(20010815)84:8<2417::AID-HLCA2417>3.0.CO;2-N
  contributor:
    fullname: Delcanale
– volume: 99
  start-page: 11
  year: 2015
  ident: 10.1016/j.ejmech.2016.05.023_bib21
  article-title: Estrogen and bone health in men and women
  publication-title: Steroids
  doi: 10.1016/j.steroids.2014.12.010
  contributor:
    fullname: Cauley
– volume: 21
  start-page: 115
  year: 2000
  ident: 10.1016/j.ejmech.2016.05.023_bib9
  article-title: Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis
  publication-title: Endocr. Rev.
  contributor:
    fullname: Manolagas
– volume: 138
  start-page: 5067
  year: 1997
  ident: 10.1016/j.ejmech.2016.05.023_bib51
  article-title: Differential epression of estrogen receptors α and β mRNA during differentiation of human osteoblast SV-HFO cells
  publication-title: Endocrinology
  doi: 10.1210/endo.138.11.5652
  contributor:
    fullname: Arts
– volume: 29
  start-page: 155
  year: 2013
  ident: 10.1016/j.ejmech.2016.05.023_bib13
  article-title: Receptor activator of nuclear factor κB ligand and osteoprotegerin regulation of bone remodeling in health and disease
  publication-title: Endocr. Rev.
  doi: 10.1210/er.2007-0014
  contributor:
    fullname: Kearns
– volume: 85
  start-page: 2307
  year: 1988
  ident: 10.1016/j.ejmech.2016.05.023_bib19
  article-title: Enhanced osteoblast proliferation and collagen gene expression by estradiol
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.85.7.2307
  contributor:
    fullname: Ernst
– volume: 3
  start-page: S131
  year: 2008
  ident: 10.1016/j.ejmech.2016.05.023_bib6
  article-title: Normal bone anatomy and physiology
  publication-title: Clin. J. Am. Soc. Nephrol.
  doi: 10.2215/CJN.04151206
  contributor:
    fullname: Clarke
– volume: 15
  start-page: 97
  year: 1989
  ident: 10.1016/j.ejmech.2016.05.023_bib38b
  article-title: Metabolic and clinical effects of ipriflavone in established post-menopausal osteoporosis
  publication-title: Drugs Exp. Clin. Res.
  contributor:
    fullname: Agnusdei
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Snippet A series of 3,4-diarylbenzopyran based amide derivatives was synthesized and evaluated for osteogenic activity in in vitro and in vivo models of osteoporosis....
A series of 3,4-diarylbenzopyran based amide derivatives was synthesized and evaluated for osteogenic activity in in vitro and in vivo models of osteoporosis....
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StartPage 82
SubjectTerms Amides - chemistry
Amides - pharmacokinetics
Amides - pharmacology
Animals
Antiosteoporotic
Benzopyran
Benzopyrans - chemistry
Benzopyrans - pharmacokinetics
Benzopyrans - pharmacology
Biological Availability
Cell Differentiation - drug effects
Chemistry, Medicinal
Estrogen
Estrogen Receptor beta - metabolism
Isoflavone
Life Sciences & Biomedicine
Mice
Mice, Inbred BALB C
Osteoblasts - cytology
Osteogenesis - drug effects
Osteogenic
Osteoporosis - chemically induced
Pharmacology & Pharmacy
Science & Technology
Stem Cells - cytology
Structure-Activity Relationship
Title Differentiation of skeletal osteogenic progenitor cells to osteoblasts with 3,4-diarylbenzopyran based amide derivatives: Novel osteogenic agents
URI https://dx.doi.org/10.1016/j.ejmech.2016.05.023
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https://www.ncbi.nlm.nih.gov/pubmed/27236065
Volume 121
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