Insight into the interaction between PriB and DnaT on bacterial DNA replication restart: Significance of the residues on PriB dimer interface and highly acidic region on DnaT

• Published in: Biochimica et biophysica acta. Proteins and proteomics Vol. 1867; no. 4; pp. 367 - 375
• Main Authors: Fujiyama, Saki, Abe, Yoshito, Shiroishi, Mitsunori, Ikeda, Yohei, Ueda, Tadashi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2019
• Subjects: DNA binding protein; Gram-negative bacteria; Primosome; Protein-protein interaction; Replication restart; Replication restart; Gram-negative bacteria; Protein-protein interaction; Primosome; DNA binding protein

When the replisome collapses at a DNA damage site, a sequence-independent replication restart system is required. In Escherichia coli, PriA, PriB, and DnaT assemble in an orderly fashion at the stalled replication fork and achieve the reloading of the replisome. PriB-DnaT interaction is considered a...