Lithium-stabilized nucleophilic addition of thiamin to a ketone provides an efficient route to mandelylthiamin, a critical pre-decarboxylation intermediate - Bielecki, Michael; Howe, Graeme W.; Kluger, Ronald (Bioorganic chemistry, 2015)
Keywords: Analysis; Benzoylformate; Chemistry Techniques, Synthetic; Equilibrium; Ketones - chemistry; Lewis Acids - chemistry; Lithium - chemistry; Lithium ion stabilization; Mandelic Acids - chemical synthesis; Nucleophilic carbene; Predecarboxylation intermediate; Protecting group; Synthesis; Thiamin; Thiamine - analogs & derivatives; Thiamine - chemical synthesis; Thiamine - chemistry; Nucleophilic carbene; Protecting group; Synthesis; Analysis; Predecarboxylation intermediate; Benzoylformate; Lithium ion stabilization; Equilibrium; Thiamin