Networks of phobic fear: Functional connectivity shifts in two subtypes of specific phobia

• Published in: Neuroscience letters Vol. 662; pp. 167 - 172
• Main Authors: Stefanescu, Maria R., Endres, Ralph J., Hilbert, Kevin, Wittchen, Hans-Ulrich, Lueken, Ulrike
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.01.2018
• Subjects: Adult; Amygdala; Amygdala - physiopathology; Anterior cingulate cortex; Brain - diagnostic imaging; Brain - physiopathology; Brain Mapping; Cerebral Cortex - physiopathology; Fear - physiology; Fear regulation; Female; Functional connectivity; Gyrus Cinguli - physiopathology; Humans; Insula; Magnetic Resonance Imaging; Male; Neural Pathways - physiopathology; Phobic Disorders - diagnostic imaging; Phobic Disorders - physiopathology; Specific phobia; Young Adult; Functional connectivity; Insula; Specific phobia; Amygdala; Anterior cingulate cortex; Fear regulation

•Phobic fear may be associated with connectivity in emotion-processing circuits.•We found a positive coupling between para-limbic regions in phobia groups only.•The observed negative connectivity in controls might represent fear inhibition.•Stimulus modality may alter functional brain connectivity i...