An association selected polymorphisms of XRCC1, OGG1 and MUTYH gene and the level of efficiency oxidative DNA damage repair with a risk of colorectal cancer

• Published in: Mutation research Vol. 745-746; p. 6
• Main Authors: Przybylowska, Karolina, Kabzinski, Jacek, Sygut, Andrzej, Dziki, Lukasz, Dziki, Adam, Majsterek, Ireneusz
• Format: Journal Article
• Language: English
• Published: Netherlands 01.05.2013
• Subjects: Aged; Case-Control Studies; Colorectal Neoplasms - genetics; Colorectal Neoplasms - pathology; Comet Assay; DNA Damage; DNA Glycosylases - genetics; DNA Repair - drug effects; DNA Repair - genetics; DNA-Binding Proteins - genetics; Epistasis, Genetic; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Hydrogen Peroxide - pharmacology; Male; Middle Aged; Poland; Polymorphism, Single Nucleotide; X-ray Repair Cross Complementing Protein 1

Oxidative damage has been implicated in the pathogenesis of colorectal cancer (CRC). The base excision repair (BER) pathway is the major DNA repair pathway for oxidative DNA damage and genetic variation associated with impaired BER might thus increase a risk of CRC. In this work, we evaluated associ...