Alpha-synuclein oligomerization and dopaminergic degeneration occur synchronously in the brain and colon of MPTP-intoxicated parkinsonian monkeys

• Published in: Neuroscience letters Vol. 716; p. 134640
• Main Authors: Li, Xuran, Yang, Weiwei, Li, Xin, Chen, Min, Liu, Chengwei, Li, Jie, Yu, Shun
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 18.01.2020
• Subjects: alpha-Synuclein - metabolism; Animals; Brain - metabolism; Brain - pathology; Colon; Dopaminergic neurons; Dopaminergic Neurons - pathology; Enteric Nervous System - metabolism; Enteric Nervous System - pathology; Macaca fascicularis; Male; Nerve Degeneration - metabolism; Nerve Degeneration - pathology; Parkinsonian Disorders - metabolism; Parkinsonian Disorders - pathology; Parkinson’s disease; Striatum; Substantia nigra; α-synuclein; DAergic; Substantia nigra; CNS; ENS; MPP; STR; m-α; Dopaminergic neurons; p-α-syn; SD; Striatum; PNS; SN; Colon; α-synuclein; PBS; t-α-syn; EGCG; PLK2; PP2A; PVDF; NSS; LNs; SDS-PAGE; PD; TH; α-syn; o-α-syn; DAT; MPTP; LBs; Parkinson’s disease; ELISA

•α-Syn oligomerization occurs in parallel in the brain and colon of MPTP-treated monkeys.•α-Syn oligomerization correlates with its phosphorylation in MPTP-treated monkeys.•α-Syn phosphorylation is accompanied by alterations in its regulatory enzymes PP2A and PLK2.•DAergic degeneration is synchroniz...