STAT3 as a therapeutic target in the metformin-related treatment
[Display omitted] •Metformin has proved to be benifitial to various dseases.•STAT3 signaling plays an important role in mediating many pathological processes.•STAT3 signaling pathway is an important AMPK-independent pathway in metformin treatment. Signal transducers and activators of transcription 3...
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| Published in | International immunopharmacology Vol. 116; p. 109770 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.03.2023
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| Subjects | |
| Online Access | Get full text |
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| Abstract | [Display omitted]
•Metformin has proved to be benifitial to various dseases.•STAT3 signaling plays an important role in mediating many pathological processes.•STAT3 signaling pathway is an important AMPK-independent pathway in metformin treatment.
Signal transducers and activators of transcription 3 (STAT3) signaling plays an important role in mediating tumor progression, inflammation, cardiovascular disease, and other pathological processes.In recent years, STAT3 as a therapeutic target has received extensive attention. It is well known that metformin can play the role of hypoglycemia by activating AMP-activated protein kinase (AMPK) through inhibition of mitochondrial ATP production.However, AMPK is not required for metformin activity.Although the application of STAT3 as a therapeutic target of metformin is still in the initial research stage, the importance of STAT3 in the mechanism of metformin is gradually being recognizedand further studies are needed to demonstrate the important role of the STAT3 regulatory network in the regulation of diseases by metformin. Here, we reviewed in detail that metformin inhibits the progression of various diseases like tumors, autoimmune diseases and hormone-related diseases by regulating multiple signaling pathways such as JAK/STAT3 and mTOR/STAT3 signaling centered on STAT3. We also summarized recent advances of STAT3 inhibitors combined with metformin in the treatment of diseases.We emphasized that STAT3 signaling, as an AMPK-independent signaling pathway, may be an important target for metformin in clinical therapy. |
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| AbstractList | [Display omitted]
•Metformin has proved to be benifitial to various dseases.•STAT3 signaling plays an important role in mediating many pathological processes.•STAT3 signaling pathway is an important AMPK-independent pathway in metformin treatment.
Signal transducers and activators of transcription 3 (STAT3) signaling plays an important role in mediating tumor progression, inflammation, cardiovascular disease, and other pathological processes.In recent years, STAT3 as a therapeutic target has received extensive attention. It is well known that metformin can play the role of hypoglycemia by activating AMP-activated protein kinase (AMPK) through inhibition of mitochondrial ATP production.However, AMPK is not required for metformin activity.Although the application of STAT3 as a therapeutic target of metformin is still in the initial research stage, the importance of STAT3 in the mechanism of metformin is gradually being recognizedand further studies are needed to demonstrate the important role of the STAT3 regulatory network in the regulation of diseases by metformin. Here, we reviewed in detail that metformin inhibits the progression of various diseases like tumors, autoimmune diseases and hormone-related diseases by regulating multiple signaling pathways such as JAK/STAT3 and mTOR/STAT3 signaling centered on STAT3. We also summarized recent advances of STAT3 inhibitors combined with metformin in the treatment of diseases.We emphasized that STAT3 signaling, as an AMPK-independent signaling pathway, may be an important target for metformin in clinical therapy. Signal transducers and activators of transcription 3 (STAT3) signaling plays an important role in mediating tumor progression, inflammation, cardiovascular disease, and other pathological processes.In recent years, STAT3 as a therapeutic target has received extensive attention. It is well known that metformin can play the role of hypoglycemia by activating AMP-activated protein kinase (AMPK) through inhibition of mitochondrial ATP production.However, AMPK is not required for metformin activity.Although the application of STAT3 as a therapeutic target of metformin is still in the initial research stage, the importance of STAT3 in the mechanism of metformin is gradually being recognizedand further studies are needed to demonstrate the important role of the STAT3 regulatory network in the regulation of diseases by metformin. Here, we reviewed in detail that metformin inhibits the progression of various diseases like tumors, autoimmune diseases and hormone-related diseases by regulating multiple signaling pathways such as JAK/STAT3 and mTOR/STAT3 signaling centered on STAT3. We also summarized recent advances of STAT3 inhibitors combined with metformin in the treatment of diseases.We emphasized that STAT3 signaling, as an AMPK-independent signaling pathway, may be an important target for metformin in clinical therapy. |
| ArticleNumber | 109770 |
| Author | Li, Daisong Chu, Xianming Kong, Bin Li, Bing Zhang, Weiran |
| Author_xml | – sequence: 1 givenname: Weiran surname: Zhang fullname: Zhang, Weiran email: 2393398394@qq.com organization: Qingdao University, Qingdao, Shandong 266100, China – sequence: 2 givenname: Daisong surname: Li fullname: Li, Daisong email: lcyxlds@163.com organization: Qingdao University, Qingdao, Shandong 266100, China – sequence: 3 givenname: Bing surname: Li fullname: Li, Bing email: libing516@qdu.edu.cn organization: Qingdao University, Qingdao, Shandong 266100, China – sequence: 4 givenname: Xianming surname: Chu fullname: Chu, Xianming email: chuxianming@qdu.edu.cn organization: the Affiliated Hospital of Qingdao University, No. 59 Haier Road, Qingdao, Shandong 266100, China – sequence: 5 givenname: Bin surname: Kong fullname: Kong, Bin email: kongbin1970@126.com organization: the Affiliated Hospital of Qingdao University, No. 59 Haier Road, Qingdao, Shandong 266100, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36746021$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_exer_2023_109748 crossref_primary_10_1002_slct_202305142 crossref_primary_10_1016_j_intimp_2023_111124 crossref_primary_10_1002_mco2_290 crossref_primary_10_3390_ph17030396 crossref_primary_10_1093_bjd_ljad305 crossref_primary_10_3390_biom13071085 crossref_primary_10_1016_j_prmcm_2024_100477 crossref_primary_10_1007_s10067_023_06765_8 crossref_primary_10_12677_TCM_2023_124131 |
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| Title | STAT3 as a therapeutic target in the metformin-related treatment |
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