Individual factors define the overall effects of dietary genistein exposure on breast cancer patients

• Published in: Nutrition research (New York, N.Y.) Vol. 67; pp. 1 - 16
• Main Authors: Liu, Ren, Yu, Xiaowei, Chen, Xin, Zhong, Hongfei, Liang, Chenglin, Xu, Xiaolin, Xu, Wenxiu, Cheng, Yu, Wang, Wei, Yu, Lehan, Wu, Yudong, Yan, Nianlong, Hu, Xiaojuan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2019
• Subjects: Breast cancer; Estrogen receptors; Gene mutations; Genistein; Individual effects; Metabolism; Individual effects; TEBs; Genistein; DMBA; Estrogen receptors; Breast cancer; BRCA1; Metabolism; E2; ER; SULTs; GEN; MPSF; SF; Gene mutations; UGTs; SNPs

As an endocrine disruptor, tyrosine kinase inhibitor, and DNA methyltransferase inhibitor, genistein can interfere with breast cancer development. However, as the results of numerous studies are contradictory, it is unclear whether genistein plays a positive or negative role. Retrospective epidemiol...