The SP1/SIRT1/ACLY signaling axis mediates fatty acid oxidation in renal ischemia–reperfusion-induced renal fibrosis

• Published in: International immunopharmacology Vol. 132; p. 112002
• Main Authors: Wu, Huailiang, Wang, Liyan, Kang, Peng, Zhou, Xiangjun, Li, Wei, Xia, Zhongyuan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 10.05.2024
• Subjects: Acute Kidney Injury - genetics; Acute Kidney Injury - metabolism; Acute Kidney Injury - pathology; Animals; Disease Models, Animal; Fatty acid oxidation; Fatty Acids - metabolism; Fibrosis; Histone acetylation; Humans; Kidney - metabolism; Kidney - pathology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidation-Reduction; Renal fibrosis; Renal ischemic-reperfusion injury; Reperfusion Injury - metabolism; Reperfusion Injury - pathology; Signal Transduction; SIRT1; Sirtuin 1 - genetics; Sirtuin 1 - metabolism; Sp1 Transcription Factor - genetics; Sp1 Transcription Factor - metabolism; Fatty acid oxidation; Histone acetylation; Renal ischemic-reperfusion injury; Renal fibrosis; SIRT1

•The expression of Sirt1 was decreased in renal fibrosis induced by renal ischemia–reperfusion.•Overexpression or knockout Sirt1 in vivo alleviated and aggravated renal fibrosis.•Sirt1 regulated the ACLY transcription by inhibited the enrich of H3K27ac in the promoter of ACLY.•Fatty acid oxidation m...