A ferutinin analogue with enhanced potency and selectivity against ER-positive breast cancer cells in vitro

• Published in: Biomedicine & pharmacotherapy Vol. 105; pp. 267 - 273
• Main Authors: Safi, Rémi, Hamade, Aline, Bteich, Najat, El Saghir, Jamal, Assaf, Mona Diab, El-Sabban, Marwan, Najjar, Fadia
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.09.2018
• Subjects: Breast cancer; Estrogen; Ferutinin; Hemi-synthetic analogue; Stem/progenitor cells; BC; Hemi-synthetic analogue; BCSCs; Estrogen; FRT; HRT; E2; SC; SD; Ferutinin; FBS; Stem/progenitor cells; IC50; p-ER; CSCs; SFU; Breast cancer; SERM; EDTA; ER; 3D; Ca2; HAEC; PI; CTL

[Display omitted] •A hemi-synthetic analogue of the natural phytoestrogen ferutinin is designed to overcome its estrogenic activity.•Ferutinin analogue induces a cytotoxic effect 30 times higher than that of ferutinin towards MCF-7 cell line.•Treatment with ferutinin analogue (1 μM) produced signifi...