Serum Dehydroepiandrosterone sulfate (DHEA-S) level and its potential impact on immune responses and symptom severity after Oxford-AstraZeneca COVID-19 vaccination

• Published in: International immunopharmacology Vol. 133; p. 112057
• Main Authors: Abbasifard, Mitra, Dehghan Banadaki, Maryam, Taghipour Khaje Sharifi, Gholamhossein, Rahnama, Amir, Bagheri-Hosseinabadi, Zahra
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 30.05.2024
• Subjects: Adult; Antibodies, Neutralizing - blood; Antibodies, Viral - blood; COVID-19; COVID-19 - blood; COVID-19 - immunology; COVID-19 - prevention & control; COVID-19 Vaccines - administration & dosage; COVID-19 Vaccines - immunology; Cytokines - blood; Dehydroepiandrosterone Sulfate - blood; DHEA-S; Female; Humans; Immunoglobulin G - blood; Interferon-gamma - blood; Leukocytes, Mononuclear - immunology; Male; Middle Aged; Protective antibody; SARS-CoV-2; SARS-CoV-2 - immunology; Vaccination; COVID-19; SARS-CoV-2; Protective antibody; DHEA-S

•No significant difference observed in DHEA-S levels before and after the first and second doses of vaccination.•IL-2 and IFN-γ levels significantly increased in PBMC supernatant two weeks after both initial and booster vaccinations.•Serum IgM levels significantly rose two weeks after the first dose...